Nanobubble technologies: Applications in therapy from molecular to cellular level

Hansen, Helena H W B; Cha, Haotian; Ouyang, Lingxi; Zhang, Jun; Jin, Bo; Stratton, Helen; Nguyen, Nam‐Trung; An, Hongjie

doi:10.1016/j.biotechadv.2022.108091

Cited by 21 publications

(4 citation statements)

References 190 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, in optofluidic control, the motion of fluids is driven by bubbles generated within nanofluids, which are considered as crucial factors . In optical detection, nanobubbles have been found to serve as effective optical amplifiers, capable of enhancing the image of target cells by increasing the scattering light . According to investigations in biomedicine, the mechanical impact accompanied by nanobubble formation can open cell membranes, which facilitate the transport and release process of drugs .…”

Section: Introductionmentioning

confidence: 99%

“…5 In optical detection, nanobubbles have been found to serve as effective optical amplifiers, capable of enhancing the image of target cells by increasing the scattering light. 6 According to investigations in biomedicine, the mechanical impact accompanied by nanobubble formation can open cell membranes, which facilitate the transport and release process of drugs. 7 Therefore, it is crucial to study the generation processes of nanobubbles.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Promotion of Nanobubble Formation around Light-Induced Plasmonic Nanoparticles: A Molecular Dynamics and Continuum Modeling Comparative Study

Zhao,

Sun,

Zheng

et al. 2023

J. Phys. Chem. C

View full text Add to dashboard Cite

The nucleation threshold of nanobubble formation around the surface of nanoparticles with small sizes is significantly high under the irradiation of incident light, which has limited their applications in the fields of optofluidics and biomedicine. To solve this problem, nanoparticles are assembled into an array to investigate the generation process of nanobubbles around them under the impact of the localized surface plasmon resonance (LSPR)-induced enhanced electric field (EEF) by using molecular dynamics (MD) simulations and continuum equations. The results of MD simulations indicate that even if the nanoparticle temperature is close to the melting point, it is still difficult to generate nanobubbles around the surface of an individual nanoparticle with a radius of 2 nm. However, when nanoparticles are assembled into an array, the progressive nucleation and generation process of nanobubbles around their surface can be observed after a thermal diffusion process lasting approximately 1050 ps. When the LSPR effect is excited, water molecules can be rapidly transformed from the liquid state to the gaseous state under the perturbation of an intensive EEF, which can further promote the generation process of nanobubbles. Moreover, using the thermal diffusion equation with a modification of the interfacial thermal resistance, a detailed analysis is also conducted for the phase change process of the water region surrounding nanoparticles under the effect of the LSPR-induced EEF. Compared with the results of MD simulations, it can be observed that the modified thermal diffusion equation can clearly demonstrate the initial nucleation of nanobubbles around the surface of a nanoparticle array but the size of the generated nanobubble is slightly smaller. On this basis, the generation process of nanobubbles can be flexibly manipulated by adjusting the gap distance of an array, the number of nanoparticles in an array, and the polarization direction of the incident light. The results could provide a new approach to investigate the nucleation and generation process of nanobubbles, which makes them more attractive in various emerging applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Promotion of Nanobubble Formation around Light-Induced Plasmonic Nanoparticles: A Molecular Dynamics and Continuum Modeling Comparative Study

Zhao,

Sun,

Zheng

et al. 2023

J. Phys. Chem. C

View full text Add to dashboard Cite

show abstract

“…Although many methods have been developed to prepare microbubbles, only a few have been used to produce nanobubbles. Some methods such as solvent exchange method, temperature-dependent method, and water/saline solution exchange method as well as photochemical/electrochemical process are mainly used to form free nanobubbles [ − ]. For shelled nanobubbles production, additional auxiliary means or separation steps are required [], which makes these methods more complex.…”

Section: Introductionmentioning

confidence: 99%

From Nanovesicles to Nanobubbles Based on Repeated Compression Method

Chen,

Miao,

Yang

et al. 2023

Langmuir

View full text Add to dashboard Cite

Nanobubbles have been increasingly applied in biomedicine, which is attributed to their ability to work as ultrasound imaging contrast agents and powerful gene/drug carriers. Different production techniques or approaches have been developed to generate uniform and stable shelled nanobubbles. However, these shelled nanobubbles are usually prepared based on disordered shell materials, such as free phospholipids and polymers. In recent years, the continuous repeated compression method for a gas−liquid mixture has been developed to produce free and lipid-shelled nanobubbles. In this study, to explore the response of well-organized nanostructures to this method, the repeated compression method was used to treat preprepared liposomes and polymeric nanovesicles. Size distribution, morphologies, and ultrasound image contrast enhancement of these nanovesicles were determined before and after repeated compression. Results demonstrate that the presence of a phospholipid bilayer is vital to form liposome-based nanobubbles. And the low elastic modulus of the polymeric membrane is key to encapsulate gases into polymeric nanovesicles. Overall, it demonstrated the advantages of well-organized nanostructures to produce nanobubble structures, giving new insights into the preparation and understanding of nanobubbles.

show abstract

“…Chitosan ND are spherical nanovesicles composed of a liquid or vaporizable core stabilized by a polysaccharide shell [34]. They have been investigated by different authors as innovative nanoplatforms for the delivery of drug, gases and genetic material [35][36][37]. Previously, our group developed several chitosan ND formulations for the treatment of infectious diseases [38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Anti-Herpetic Activity of Valacyclovir Loaded in Sulfobutyl-ether-β-cyclodextrin-decorated Chitosan Nanodroplets

Argenziano,

Arduino,

Rittà

et al. 2023

Microorganisms

View full text Add to dashboard Cite

Valacyclovir (VACV) was developed as a prodrug of the most common anti-herpetic drug Acyclovir (ACV), aiming to enhance its bioavailability. Nevertheless, prolonged VACV oral treatment may lead to the development of important side effects. Nanotechnology-based formulations for vaginal administration represent a promising approach to increase the concentration of the drug at the site of infection, limiting systemic drug exposure and reducing systemic toxicity. In this study, VACV-loaded nanodroplet (ND) formulations, optimized for vaginal delivery, were designed. Cell-based assays were then carried out to evaluate the antiviral activity of VACV loaded in the ND system. The chitosan-shelled ND exhibited an average diameter of about 400 nm and a VACV encapsulation efficiency of approximately 91% and was characterized by a prolonged and sustained release of VACV. Moreover, a modification of chitosan shell with an anionic cyclodextrin, sulfobutyl ether β-cyclodextrin (SBEβCD), as a physical cross-linker, increased the stability and mucoadhesion capability of the nanosystem. Biological experiments showed that SBEβCD-chitosan NDs enhanced VACV antiviral activity against the herpes simplex viruses type 1 and 2, most likely due to the long-term controlled release of VACV loaded in the ND and an improved delivery of the drug in sub-cellular compartments.

show abstract

Nanobubble technologies: Applications in therapy from molecular to cellular level

Cited by 21 publications

References 190 publications

Promotion of Nanobubble Formation around Light-Induced Plasmonic Nanoparticles: A Molecular Dynamics and Continuum Modeling Comparative Study

Promotion of Nanobubble Formation around Light-Induced Plasmonic Nanoparticles: A Molecular Dynamics and Continuum Modeling Comparative Study

From Nanovesicles to Nanobubbles Based on Repeated Compression Method

Enhanced Anti-Herpetic Activity of Valacyclovir Loaded in Sulfobutyl-ether-β-cyclodextrin-decorated Chitosan Nanodroplets

Contact Info

Product

Resources

About