Nanocapsulated curcumin: Oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat

Ghosh, Dibakar; Choudhury, Somnath Ray; Ghosh, Swarupa; Mandal, Ardhendu; Sarkar, Siddik; Ghosh, Anup K.; Saha, Krishna Das; Das, Nirmalendu

doi:10.1016/j.cbi.2011.12.004

Cited by 148 publications

(77 citation statements)

References 36 publications

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“…38 Several researchers have reported increased oxidative stress parameters such as MDA, DC, PC, and DNA damage together with decreased non-enzymatic and enzymatic antioxidants in the liver due to DEN treatment. [3][4][5][6]34,39,40 In the current study, increases in hepatic MDA, DC, and PC levels and decreases in SOD, CAT, and GSH-Px activities were due to DEN treatment. However, GSH levels and GST activities were observed as increased due to DEN treatment.…”

Section: Discussionmentioning

confidence: 79%

“…2,8,9,32,33 Compared to the other models, reproduction of cirrhosis and HCC sequentially as similar to human liver disease becomes possible with this protocol and this may enable the usage of some agents to prevent the progression of cirrhosis to advanced stages. 2,7,34 In the current study, rats were injected with DEN (200 mg/kg; i.p.) three times with an interval of 15 days at 4, 6, and 8 weeks, as previously reported, 33,35 and sacrificed 8 weeks after the last Figure 3.…”

Section: Discussionmentioning

confidence: 99%

“…These findings agree with the results of previous studies. 7,[33][34][35] BB contains polyphenols, flavonoids, and other active components and its powerful antioxidant actions may be due to free radical scavenger properties. 14,15 BB consumption was reported to be useful in oxidative stress-related conditions.…”

Section: Discussionmentioning

confidence: 99%

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Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats

Bingül

Başaran-Küçükgergin

Aydın

et al. 2016

Int J Immunopathol Pharmacol

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Diethylnitrosamine (DEN)-induced liver cancer normally develops in stages that progress from cirrhosis and carcinoma. Increased oxidative stress is suggested to play a role in DEN-induced carcinogenicity. Blueberries (BB) contain high antioxidant capacity. We investigated the effect of BB supplementation on development of DEN-induced cirrhosis and neoplastic lesions in the liver. Rats were injected with DEN (200 mg/kg; i.p.) three times with an interval of 15 days at 4, 6, and 8 weeks and sacrificed 8 weeks after the last DEN injection. They were also fed on 8% BB (w/w) containing chow for 16 weeks. Hepatic damage markers in serum were determined together with hepatic histopathological examinations. Hydroxyproline (HYP), malondialdehyde (MDA), diene conjugate (DC), protein carbonyl (PC), and glutathione (GSH) levels, and CuZn-superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, and their mRNA expressions were measured. Protein and mRNA expressions of glutathione transferase-pi (GST-pi) were evaluated as a marker of preneoplastic lesions. BB supplementation decreased hepatic damage markers in serum and hepatic MDA, DC, and PC levels, but SOD, CAT, and GSH-Px activities and their mRNA expressions remained unchanged in DEN-treated rats. BB attenuated cirrhotic changes and decreased hepatic HYP levels and GST-pi expressions. Our results indicate that BB is effective in decreasing development of DEN-induced hepatic cirrhosis and preneoplastic lesions by acting as an antioxidant (radical scavenger) itself without affecting activities and mRNA expressions of antioxidant enzymes.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats

Bingül

Başaran-Küçükgergin

Aydın

et al. 2016

Int J Immunopathol Pharmacol

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“…For instance, some adjuvants could increase the solubility of hydrophobic drugs and then improve the therapeutic effect of TCM for HCC [126]. Simultaneously, many studies showed that application of new drug delivery systems is a good way to improve bioavailability, such as a selfmicro-emulsifying drug delivery system [127], a single-walled carbon nanotubes delivery system [128], spray congealing technology [129], a nanoparticle drug delivery system [130], and a polymeric delivery system [131]. Hence, development of new drug delivery systems will be the most important therapeutic modalities for the future treatment of HCC.…”

Section: Exploring the New Therapeutic Modalities Of Tcm For Treatmenmentioning

confidence: 99%

Traditional Chinese medicine combined with other therapies for treatment of hepatocellular carcinoma in clinical trials

Feng¹,

Zhu²,

Hu³

et al. 2017

Cancer Rep Rev

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide with a high mortality, and still there are only few effective methods to treat it. To this end, alternative medicines from traditional Chinese medicine (TCM) are being investigated for their ability to eliminate the tumor or halt its progression. A large number of studies have shown that TCM can be an effective approach to treat the HCC in clinical trials when used alone or in combination with other therapies. Thus, TCM has made significant progress, and has begun to gain worldwide popularity for promoting healthcare and HCC treatment. Because of this progress, periodic summaries are needed to facilitate further research for the use of TCM to treat HCC. This paper provides a comprehensive summary of this work with regard to the following aspects: herbalist views on the etiology and therapeutic principles for treatment of HCC, treating HCC by TCM alone, treating HCC with TCM in combination with resection, chemotherapy, radiotherapy and interventional therapy, and other therapies. Additionally, the current main problems and future application prospects for treatment of HCC by TCM described, which could provide scientific guidance for clinician as well as references for the treatment of other cancers.

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“…Curcumin can be acted as effective stabilizing agent and exhibit considerable effectiveness in medicinal activity. [42][43][44] The investigation of antimicrobial activity of the non-functionalized as well as biofunctionalized MONP was investigated against Grampositive bacteria (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Escherichia coli and Salmonella typhi), and some funguses (Candida albicans, Curvularia lunata, Aspergillus niger, and Trichophyton simii). From the report, there was a good improvement in the activity was observed for biofunctionalized NPs than the non-functionalized NPs against tested bacterial and fungal species.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Haneefa

2017

AJP

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Aim: In this study, we have demonstrated the synthesis of manganese metal oxide nanoparticles (NPs) by a green synthesis manner using lemon extract as a reducing agent and turmeric curcumin extract as capping agent. The as-synthesized nanomaterials were biofunctionalized with salicylalchitosan which was obtained from the source of chitosan to enhance the antimicrobial activity of those materials. Materials and Methods: The synthesized materials were characterized using ultraviolet-visible and Fourier transform infrared spectroscopic techniques. Scanning electron microscopy and transmission electron microscopy analysis were employed to evaluate the morphological and structural properties of the both synthesized nanoforms. Furthermore, the effect of antibacterial and antifungal activity of those materials was analyzed using some standard Gram-positive and Gram-negative bacteria and funguses. Results: The morphological studies represented that both non-functionalized and biofunctionalized manganese oxide NPs (MONPs) formed are of spherical morphology but exhibited with difference in size about 50 nm and 40-60 nm, respectively. The performance of antimicrobial activity of biofunctionalized MONPs was exhibited better than the non-functionalized NPs. Conclusion: The results are revealed that the biofunctionalized MONPs showed higher antibacterial and antifungal activities, and our findings from this work have been provided the new way in the potential application of MONPs through a biofunctionalization process in the clinical and drug invention field.

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Nanocapsulated curcumin: Oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat

Cited by 148 publications

References 36 publications

Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats

Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats

Traditional Chinese medicine combined with other therapies for treatment of hepatocellular carcinoma in clinical trials

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