Nanocapsules: Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy (Adv. Healthcare Mater. 11/2015)

Xuan, Minjun; Shao, Jianzhong; Dai, Luru; He, Qiang; Li, Junbai

doi:10.1002/adhm.201570064

Cited by 11 publications

(7 citation statements)

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“…[ 172 ] This property enables macrophage membranes have attracted researchers' attention as a kind of bacterial targeting material. [ 173 ] For example, Wang et al [ 164 ] reported a gold and silver nanocage (GSNC) coated with macrophage membrane by extrusion technique. Due to the bacterial recognizing receptors on macrophage membranes, macrophage membranes‐coated GSNC could be effectively enriched in the infection site.…”

Section: Super‐antibacterial Systemsmentioning

confidence: 99%

Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

et al. 2021

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Healthcare-acquired infections as well as increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene have attracted great interest, in particular, the emergence of surface design strategies offer an effective alternative to antibiotics, thereby preventing the possible development of bacterial resistance. In this review, recent progress on advanced surface modifications to prevent bacterial infections are addressed comprehensively, starting with the key factors against bacterial adhesion, followed by varying strategies that can inhibit biofilm formation effectively. Furthermore, "super antibacterial systems" through pre-treatment defense and targeted bactericidal system, are proposed with increasing evidence of clinical potential. Finally, the advantages and future challenges of surface strategies to resist healthcare-associated infections are discussed, with promising prospects of developing novel antimicrobial materials.

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Section: Super‐antibacterial Systemsmentioning

confidence: 99%

Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

et al. 2021

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“…[85] In the field of nanomedicine, imaging and phototherapy play an important role in expanding the functions of nanomaterials. [224] Considering their therapeutic application in drug delivery, potential cancer treatment was investigated by modifying and encapsulating nanomaterials within different types of membrane vesicles, including RBC, macrophage, platelet, and other membrane vesicles, [103,225,226] as encapsulation within membrane vesicles could reduce immune clearance. [227] Piao et al used an RBC membrane vesicle encapsulating a gold nanocage against a murine 4T1 tumor model and elevating the temperature from 35 to 41 °C using NIR irradiation for 10 min.…”

Section: Cancer Therapymentioning

confidence: 99%

Bridging the Gap between Nonliving Matter and Cellular Life

Kumar

Karmacharya

Cho

2022

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with simple primitive life. However, whether life emerges from scratch from nonliving matter remains a mystery. Accordingly, understanding the fundamental principles of life processes is still a major scientific challenge. [1] Engineers can create a biological environment absent in nature by employing synthetic biology tools, thus allowing the discovery and elucidation of fundamentally complex biological cells in ways that remain currently impossible. [2] As a result, its essential goal is to regulate the required components to enhance their complexity as the need for comprehension grows. [3] To address fundamental questions regarding the transition from chemistry to biology, the chemical techniques applied to non-living matter to produce life are divided into top-down or bottom-up synthesis. [2] The majority of the top-down approaches have focused on genetic engineering and molecular biology techniques applied to prokaryotes such as Escherichia coli (E. coli), Klebsiella pneumonia (K. pneumonia), and others to isolate and generate enzymes, drug precursors, and biofuels for their application in health, bioremediation, environmental, and other therapeutic strategies. [4,5] A bottom-up approach is typically used to create new life-like features, known as artificial cells, from cellular components or non-living matter, to better understand specific cellular characteristics and the origin of life.The generation of an artificial cell factory provides a foundation for critical cell biology research. However, the concept of an artificial cell can be controversial, as factors such as cell size, genetic composition, and morphological similarity need to be considered. [6] Vesicles such as giant unilamellar vesicles (GUVs), polysaccharidosomes, membrane-less coacervate microdroplets, and hydrogel particles are being explored to mimic the cell organelles and provide a functional unit to address their issues. [7][8][9][10] Though synthetic micro or nanoreactors have been used to mimic life-like functions and to learn about the fundamental biology of natural cells, constructing a life-like structure out of non-living building blocks remains a considerable challenge. In this review, we focus on hybrid approaches that use both natural and synthetic materials to mimic and interface with biological systems (Figure 1). Using hybrid vesicle micro or nanoreactors, bioinspired life-like functions such as chemical compartments, cascade signaling, energy generation, growth, replication, and environmental A cell, the fundamental unit of life, contains the requisite blueprint information necessary to survive and to build tissues, organs, and systems, eventually forming a fully functional living creature. A slight structural alteration can result in data misprinting, throwing the entire life process off balance. Advances in synthetic biology and cell engineering enable the predictable redesign of biological systems to perform novel functions. Individual functions and fundamental processes at the core of the biology of cells can be investig...

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“…Besides the RBC membrane, the He group recently explored different cell membranes‐functionalized particles for the applications of biomimetic drug delivery. For example, the macrophage cell membrane‐derived nanovesicles were prepared and modified onto the mesoporous silica nanocapsules . The resulting biointerfacing nanocapsules showed the evading capability of the immune attack for prolonged period in vivo, and target location in tumor sites.…”

Section: Biointerfacing Of Controlled Assembled Micro/nanomotorsmentioning

confidence: 99%

Recent Progress on Bioinspired Self‐Propelled Micro/Nanomotors via Controlled Molecular Self‐Assembly

Lin

et al. 2016

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The combination of bottom-up controllable self-assembly technique with bioinspired design has opened new horizons in the development of self-propelled synthetic micro/nanomotors. Over the past five years, a significant advances toward the construction of bioinspired self-propelled micro/nanomotors has been witnessed based on the controlled self-assembly technique. Such a strategy permits the realization of autonomously synthetic motors with engineering features, such as sizes, shapes, composition, propulsion mechanism, and function. The construction, propulsion mechanism, and movement control of synthetic micro/nanomotors in connection with controlled self-assembly in recent research activities are summarized. These assembled nanomotors are expected to have a tremendous impact on current artificial nanomachines in future and hold potential promise for biomedical applications including drug targeted delivery, photothermal cancer therapy, biodetoxification, treatment of atherosclerosis, artificial insemination, crushing kidney stones, cleaning wounds, and removing blood clots and parasites.

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Nanocapsules: Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy (Adv. Healthcare Mater. 11/2015)

Cited by 11 publications

References 0 publications

Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

Bridging the Gap between Nonliving Matter and Cellular Life

Recent Progress on Bioinspired Self‐Propelled Micro/Nanomotors via Controlled Molecular Self‐Assembly

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