Nanocarrier-based systems for wound healing

Bernal-Chávez, Sergio Alberto; Nava-Arzaluz, María Guadalupe; Quiroz-Segoviano, R.I.Y.; Ganem-Rondero, Adriana

doi:10.1080/03639045.2019.1620270

Cited by 18 publications

(10 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development and implementation of new wound healing management strategies and healthcare products is, therefore, imperative. In recent years, different technological strategies have been proposed, including clays, metals, polymers and lipid-based systems among others, as reviewed by Bernal-Chávez et al and García-Villén et al [ 4 , 5 ]. Particularly, clay-based dressings have been proven to be useful in wound healing [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

View full text Add to dashboard Cite

Background: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.

show abstract

Section: Introductionmentioning

confidence: 99%

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This phase is characterized by vascular constriction, platelet aggregation, and formation of fibrin clot through activation of enzyme thrombin which supports platelet clumps into the stable clot to stop bleeding. In this stage, platelets come into contact with collagen, resulting in activation and aggregation of platelets [10]. In addition, they release several growth factors (Table 1) which are responsible for inflammation at the site of injury including the transforming growth factor-β (TGF-β), epidermal growth factor (EGF), insulinlike growth factor-1, and platelet-derived growth factor (PDGF) [10, 16], [18,20].…”

Section: Phase 1: Hemostasis Phasementioning

confidence: 99%

“…Moreover, they require frequent application and wound coverage to ensure sterility of wounds, the therapeutic action of drugs, and to avoid wound drying [9]. Therefore, they decrease patient compliance and acceptance [10]. Nanocarriers play an important role in wound healing since they are reported to improve therapeutic action more than drugs themselves [8,9] as they act as new entities that differ from free drugs [26].…”

Section: Phase 4: Maturation Stage (Remodeling Phase)mentioning

confidence: 99%

“…Nanocarriers play an important role in wound healing since they are reported to improve therapeutic action more than drugs themselves [8,9] as they act as new entities that differ from free drugs [26]. They improve drug delivery into the skin through enhancement of the pharmacokinetics and biodistribution of drugs, hence they increase the bioavailability of drugs [10]. Moreover, they promote wound closure, reduce wound pain, enhance tissue regeneration and control wound infection and inflammation.…”

Section: Phase 4: Maturation Stage (Remodeling Phase)mentioning

confidence: 99%

See 1 more Smart Citation

Vesicular Systems Used for Wound Healing

Abdelfattah

Nasr

Ali

et al. 2021

Archives of Pharmaceutical Sciences Ain Shams University

View full text Add to dashboard Cite

When the skin is injured through physical, chemical, mechanical, and/or thermal damage, a spontaneous series of events start to happen, often called the "cascade of healing," to restore the injured tissues, replace the damaged structures and prevent the invasion of pathogens into the damaged tissues. Many traditional products are available for wound healing such as gels, creams, ointments, dressings, and solutions, which depend mainly on moisture intake to help tissue repair, yet they do not provide optimal conditions to permit recovery of the wounds. Nanocarriers play a significant role in wound healing since they are reported to improve drug delivery into the skin through the alternation of pharmacokinetics and biodistribution of drugs, hence they increase the bioavailability of drugs. Vesicular systems such as liposomes, niosomes, transfersomes, penetration enhancer containing vesicles (PEVs), and ethosomes are among the carriers proven to enhance the therapeutic action of drugs applied for wound healing. In this review, we summarize and discuss different vesicular systems used for wound healing, their composition, their advantages and disadvantages, their methods of preparation, and their mechanisms of skin penetration.

show abstract

“…Hamdan et al reported that wound healing involves four stages: (i) coagulation and haemostasis; (ii) inflammation; (iii) proliferation; and (iv) wound remodelling ( Figure 1 ) [ 2 ]. These stages occur at different timescales, in which initial coagulation can occur over minutes, while the process of tissue remodelling may last from several months to one year [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Honey-Based Nanoparticles for Wound Dressing: A Review

et al. 2022

View full text Add to dashboard Cite

Wounds with impaired healing, including delayed acute injuries and chronic injuries, generally fail to progress through normal healing stages. A deeper understanding of the biochemical processes involved in chronic wound cures is necessary to correct the microenvironmental imbalances in the wound treatment designs of products. The therapeutic benefits of honey, particularly its antimicrobial activity, make it a viable option for wound treatment in a variety of situations. Integration with nanotechnology has opened up new possibilities not only for wound healing but also for other medicinal applications. In this review, recent advances in honey-based nanoparticles for wound healing are discussed. This also covers the mechanism of the action of nanoparticles in the wound healing process and perspectives on the challenges and future trends of using honey-based nanoparticles. The underlying mechanisms of wound healing using honey are believed to be attributed to hydrogen peroxide, high osmolality, acidity, non-peroxide components, and phenols. Therefore, incorporating honey into various wound dressings has become a major trend due to the increasing demand for combination dressings in the global wound dressing market because these dressings contain two or more types of chemical and physical properties to ensure optimal functionality. At the same time, their multiple features (low cost, biocompatibility, and swelling index) and diverse fabrication methods (electrospun fibres, hydrogels, etc.) make them a popular choice among researchers.

show abstract

Nanocarrier-based systems for wound healing

Cited by 18 publications

References 110 publications

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Vesicular Systems Used for Wound Healing

Recent Advances in Honey-Based Nanoparticles for Wound Dressing: A Review

Contact Info

Product

Resources

About