Nanocarrier-loaded block copolymer dual domain organogels

Mineart, Kenneth P.; Walker, William W.; Mogollon‐Santiana, Joaquin; Coates, Ian A.; Hong, Cameron; Lee, Byeongdu

doi:10.1016/j.polymer.2020.123246

Cited by 5 publications

(4 citation statements)

References 43 publications

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“…The latter result highlights a key advantage of organogels over hydrogels in formulation of transdermal delivery media: the solvent can be tailored to alter gel properties. Our work on SEBS/mineral oil gels agrees with the former result of Ma et al and further concluded that SEBS concentration simultaneously increases gel stiffness and decreases payload release rate [17].…”

Section: Introductionsupporting

confidence: 92%

“…The values of φ PS for each gel batch are calculated from known information, namely φ PS = f S × w SEBS (ρ S /ρ g ) where f S is the fraction of polystyrene in SEBS, w SEBS is the SEBS concentration in the gel, and ρ S and ρ g are the densities of polystyrene and the gel, respectively. As a result, G c and G e are the only fitting parameters used to describe stress-stretch data with the STN model and the fitted model represents data well up to λ zz ≈ 4 as has been noted in previous studies [17,19,21]. Furthermore, the values of G c and G e determined through fitting match the observations discussed above.…”

Section: Mechanical Behaviorsupporting

confidence: 80%

“…1.7 nm. Gels were initially formulated with 10 wt%, 20 wt%, or 30 wt% copolymer and 0.5 wt% OA or 1.0 wt% AOT (values based on previous work [17,18]), resulting in six series (in each series, the MO identity was varied). Note, 1.0 wt% AOT loading resulted in cloudy gels for HB 550 and HB 1000 MOs, suggesting that precipitation occurred.…”

Section: Gel Preparationmentioning

confidence: 99%

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Decoupling of Mechanical and Transport Properties in Organogels via Solvent Variation

Mineart

Hong

Rankin

2021

Gels

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Organogels have recently been considered as materials for transdermal drug delivery media, wherein their transport and mechanical properties are among the most important considerations. Transport through organogels has only recently been investigated and findings highlight an inextricable link between gels’ transport and mechanical properties based upon the formulated polymer concentration. Here, organogels composed of styrenic triblock copolymer and different aliphatic mineral oils, each with a unique dynamic viscosity, are characterized in terms of their quasi-static uniaxial mechanical behavior and the internal diffusion of two unique solute penetrants. Mechanical testing results indicate that variation of mineral oil viscosity does not affect gel mechanical behavior. This likely stems from negligible changes in the interactions between mineral oils and the block copolymer, which leads to consistent crosslinked network structure and chain entanglement (at a fixed polymer concentration). Conversely, results from diffusion experiments highlight that two penetrants—oleic acid (OA) and aggregated aerosol-OT (AOT)—diffuse through gels at a rate inversely proportional to mineral oil viscosity. The inverse dependence is theoretically supported by the hydrodynamic model of solute diffusion through gels. Collectively, our results show that organogel solvent variation can be used as a design parameter to tailor solute transport through gels while maintaining fixed mechanical properties.

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Section: Introductionsupporting

confidence: 92%

Section: Mechanical Behaviorsupporting

confidence: 80%

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Decoupling of Mechanical and Transport Properties in Organogels via Solvent Variation

Mineart

Hong

Rankin

2021

Gels

Self Cite

View full text Add to dashboard Cite

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“…[131][132][133][134] Lastly, we note that recent studies have established that nonpolar TPEGs can be fabricated as transdermal patches to deliver hydrophobic drugs. [135] This application affords an opportunity to probe molecular diffusion through swollen, tortuous polymer networks. Since diffusive transport and mechanical properties are intimately connected to the TPEG network and copolymer nanostructure and since these features are tied directly to the properties of the incorporated oil, the mechanical and transport properties of TPEGs must be decoupled for drug delivery purposes.…”

Section: Discussionmentioning

confidence: 99%

Fundamental Principles and Emerging Opportunities for Selectively‐Solvated Block Copolymer Networks in Nonpolar Media: A Perspective

McFeaters,

Spontak

2024

Advanced Physics Research

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Block polymers remain an extensively studied class of macromolecules due to their ability to self‐organize spontaneously as a result of microphase separation into a variety of ordered nanostructures, depending on the number of contiguous sequences (“blocks”) present and their sequential arrangement. These polymers are classified as multifunctional since they exhibit two or more different property sets during application. In this work, the focus is on bicomponent block copolymers composed of soft and hard segments arranged as linear triblock or higher‐order multiblock copolymers and possessing the properties of a thermoplastic elastomer (TPE). Of particular interest are selectively‐solvated TPEs, designated as TPE gels (TPEGs), with precisely‐ and composition‐tunable properties. An important aspect of TPEs and their TPEG analogs is their elasticity, which reflects the ability of the soft block(s) to form a contiguous molecular network connected by dispersed microdomains composed of the hard block. Here, the origins of microphase separation and network formation in styrenic TPEs and TPEGs are explored, and experimental, theoretical, and simulation results are examined to elucidate chemistry‐structure‐property‐processing (CSPP) relationships in these self‐networking materials. Once such relationships are established, several unconventional technologies that can directly benefit from TPEGs, along with TPEGs fabricated from TPEs possessing different chemical moieties, are likewise considered.

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Thermoplastic Elastomers and Their Physical Gels Electrospun into Tunable Microfibrous Nonwoven Mats: Structure Formation and Property Enhancement

Shamsi,

Wells,

Yan

et al. 2024

Adv Funct Materials

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Thermoplastic elastomers (TPEs) based on styrenic block copolymers constitute excellent examples of self‐networking macromolecules that are employed in a wide range of contemporary technologies as molded parts. In such applications, these TPEs exist as dense (nonporous) films or other shapes. Here, it is first demonstrated that a series of commercial TPEs possessing comparable compositions can be electrospun from solution to form microfibers that are arranged into nonwoven mats that are breathable. An important consideration for microfiber formation is the copolymer molecular weight, which regulates i) the viscosity of the parent solution prior to electrospinning, ii) the ability of these copolymers to self‐assemble during electrospinning, iii) the microfiber morphology, and iv) the mechanical properties of the resultant microfibers. The addition of a midblock‐selective aliphatic oil to these TPEs yields thermoplastic elastomer gels (TPEGs), wherein the copolymer morphology and mechanical properties become highly composition‐tunable. Electrospinning TPEGs from a binary oil+solvent solution introduces a micelle inversion mechanism that begins with an oil‐rich micellar core and ends with a styrene‐rich micellar core, required for network stabilization, as the solvent dries during microfiber solidification. This work has implications for the production of controllably low‐modulus microfibrous materials possessing modestly improved toughness but exceptional extensibility and enhanced optical transparency.

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Nanocarrier-loaded block copolymer dual domain organogels

Cited by 5 publications

References 43 publications

Decoupling of Mechanical and Transport Properties in Organogels via Solvent Variation

Decoupling of Mechanical and Transport Properties in Organogels via Solvent Variation

Fundamental Principles and Emerging Opportunities for Selectively‐Solvated Block Copolymer Networks in Nonpolar Media: A Perspective

Thermoplastic Elastomers and Their Physical Gels Electrospun into Tunable Microfibrous Nonwoven Mats: Structure Formation and Property Enhancement

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