Nanocarriers Against Bacterial Biofilms

Nafee, Noha

doi:10.1016/b978-0-12-801317-5.00011-6

Cited by 7 publications

(2 citation statements)

References 110 publications

(152 reference statements)

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“…8,[456][457][458] The antimicrobial effectiveness using a nanosystem delivery is determined by its particle size, surface charge, and chemical composition causing interaction with the biofilm matrix and thereby greater retention leading to a higher efficacy. 459,460 Among others, the size of nanoparticles as well as its positive charge and hydrophobic nature have been found crucial for aPDT as there was described a deeper biofilm penetration by nanoparticles with these features leading to the increased antimicrobial efficacy when combined with a PS. 8,459,461 Moreover, a nanosystem protects bound PS against external factors such as light and temperature, but also functions against pH and enzymatic degradation factors.…”

Section: Nanosystem Delivery In Antibacterial Pdtmentioning

confidence: 99%

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Kolarikova

Hošíková

Dilenko

et al. 2023

Medicinal Research Reviews

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Photodynamic therapy is an alternative treatment mainly for cancer but also for bacterial infections. This treatment dates back to 1900 when a German medical school graduate Oscar Raab found a photodynamic effect while doing research for his doctoral dissertation with Professor Hermann von Tappeiner. Unexpectedly, Raab revealed that the toxicity of acridine on paramecium depends on the intensity of light in his laboratory. Photodynamic therapy is therefore based on the administration of a photosensitizer with subsequent light irradiation within the absorption maxima of this substance followed by reactive oxygen species formation and finally cell death. Although this treatment is not a novelty, there is an endeavor for various modifications to the therapy. For example, selectivity and efficiency of the photosensitizer, as well as irradiation with various types of light sources are still being modified to improve final results of the photodynamic therapy. The main aim of this review is to summarize anticancer and antibacterial modifications, namely various compounds, approaches, and techniques, to enhance the effectiveness of photodynamic therapy.

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Section: Nanosystem Delivery In Antibacterial Pdtmentioning

confidence: 99%

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Kolarikova

Hošíková

Dilenko

et al. 2023

Medicinal Research Reviews

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“…Nanotechnology is a powerful tool to improve drug delivery after administration, since nanoparticles protect encapsulated drugs and target them to the biofilm, leading to an increased therapeutic efficacy [17,18]. Amongst several types of nanoparticles, lipid nanoparticles are highlighted due to their high biocompatibility, cost-effectiveness, and controlled drug release [19].…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm Combinatory Strategy: Moxifloxacin-Loaded Nanosystems and Encapsulated N-Acetyl-L-Cysteine

et al. 2022

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Bacterial biofilms of Staphylococcus aureus, formed on implants, have a massive impact on the increasing number of antimicrobial resistance cases. The current treatment for biofilm-associated infections is based on the administration of antibiotics, failing to target the biofilm matrix. This work is focused on the development of multiple lipid nanoparticles (MLNs) encapsulating the antibiotic moxifloxacin (MOX). The nanoparticles were functionalized with d-amino acids to target the biofilm matrix. The produced formulations exhibited a mean hydrodynamic diameter below 300 nm, a low polydispersity index, and high encapsulation efficiency. The nanoparticles exhibited low cytotoxicity towards fibroblasts and low hemolytic activity. To target bacterial cells and the biofilm matrix, MOX-loaded MLNs were combined with a nanosystem encapsulating a matrix-disruptive agent: N-acetyl-L-cysteine (NAC). The nanosystems alone showed a significant reduction of both S. aureus biofilm viability and biomass, using the microtiter plate biofilm model. Further, biofilms grown inside polyurethane catheters were used to assess the effect of combining MOX-loaded and NAC-loaded nanosystems on biofilm viability. An increased antibiofilm efficacy was observed when combining the functionalized MOX-loaded MLNs and NAC-loaded nanosystems. Thus, nanosystems as carriers of bactericidal and matrix-disruptive agents are a promising combinatory strategy towards the eradication of S. aureus biofilms.

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Nebulized, macrophage-targeted, Linezolid-loaded lipid carriers for intracellular treatment of tubercular infections – In vitro/in vivo study

Makled,

Nafee,

Okasha

et al. 2024

Journal of Drug Delivery Science and Technology

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Nanocarriers Against Bacterial Biofilms

Cited by 7 publications

References 110 publications

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Antibiofilm Combinatory Strategy: Moxifloxacin-Loaded Nanosystems and Encapsulated N-Acetyl-L-Cysteine

Nebulized, macrophage-targeted, Linezolid-loaded lipid carriers for intracellular treatment of tubercular infections – In vitro/in vivo study

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