Nanocarriers and Intracellular Transport: Moving Along the Cytoskeletal Matrix

Woolf, Nancy J.; Priel, Avner; Tuszyński, Jack A.

doi:10.1007/978-3-642-03584-5_4

Cited by 2 publications

(2 citation statements)

References 235 publications

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“…Microtubules, made of tubulin protein, are the largest structural filaments in the neuron (~25 nm in diameter) and serve as a molecular highway for the transport of essential cargo throughout cells (Woolf et al, 2010). They can be visualized with IHC for tubulin protein, providing another measure of axonal degeneration.…”

Section: Other Indicators Of Axonal Integrity 2221 Microtubulesmentioning

confidence: 99%

Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: Axon transport, injury and soma loss

Nuschke

Farrell

Levesque

et al. 2015

Experimental Eye Research

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Section: Other Indicators Of Axonal Integrity 2221 Microtubulesmentioning

confidence: 99%

Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: Axon transport, injury and soma loss

Nuschke

Farrell

Levesque

et al. 2015

Experimental Eye Research

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“…Although we now know an enormous amount about the molecular components required for patterning [3,[10][11][12], it is currently unclear how the macromolecular and cellular constituents of a system orchestrate themselves to generate a specific structure and function [12][13][14][15][16]. Importantly, numerous organisms are able to readjust their pattern to a specific target morphology despite drastic external perturbations and are able to stop growth and remodelling when the correct shape is reached [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Knowing one's place: a free-energy approach to pattern regulation

Friston

Levin

Sengupta

et al. 2015

J. R. Soc. Interface.

218

261

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Understanding how organisms establish their form during embryogenesis and regeneration represents a major knowledge gap in biological pattern formation. It has been recently suggested that morphogenesis could be understood in terms of cellular information processing and the ability of cell groups to model shape. Here, we offer a proof of principle that self-assembly is an emergent property of cells that share a common (genetic and epigenetic) model of organismal form. This behaviour is formulated in terms of variational free-energy minimization—of the sort that has been used to explain action and perception in neuroscience. In brief, casting the minimization of thermodynamic free energy in terms of variational free energy allows one to interpret (the dynamics of) a system as inferring the causes of its inputs—and acting to resolve uncertainty about those causes. This novel perspective on the coordination of migration and differentiation of cells suggests an interpretation of genetic codes as parametrizing a generative model—predicting the signals sensed by cells in the target morphology—and epigenetic processes as the subsequent inversion of that model. This theoretical formulation may complement bottom-up strategies—that currently focus on molecular pathways—with (constructivist) top-down approaches that have proved themselves in neuroscience and cybernetics.

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Nanocarriers and Intracellular Transport: Moving Along the Cytoskeletal Matrix

Cited by 2 publications

References 235 publications

Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: Axon transport, injury and soma loss

Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: Axon transport, injury and soma loss

Knowing one's place: a free-energy approach to pattern regulation

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