Abstract:Alzheimer's disease (AD) is one of the most progressive neurodegenerative disorders resulting in cognitive and behavioral impairment in individuals beyond 65 years of age. It is distinguished by deposits of extracellular amyloidal protein intracellular and neurofibrillary tangles resulting in senile plaques. Significant advancement has been made in AD therapeutics; however, most of the treatment approaches are based on attenuating symptoms, implying that AD is still an insolvable neurodegenerative illness. Tho… Show more
“…An essential characteristic of nanocarriers is the controlled release of the drug at the target site, achieved thanks to their small size (1-100 nm). [18][19][20][21][22] A promising candidate for drug delivery is lipid-polymer hybrid nanoparticles (LPHNPs), which have shown higher cellular delivery efficiency in vivo compared to the efficiencies obtained from polymeric and lipid NPs since the coating of the polymeric core with lipids prolongs their circulation time. LPHNPs delay polymer degradation and minimize the leakage of encapsulated content.…”
Section: Introductionmentioning
confidence: 99%
“…An essential characteristic of nanocarriers is the controlled release of the drug at the target site, achieved thanks to their small size (1–100 nm). 18–22…”
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment associated with the accumulation of beta-amyloid protein (Aβ). Aβ activates glial cells in the brain, increasing the secretion...
“…An essential characteristic of nanocarriers is the controlled release of the drug at the target site, achieved thanks to their small size (1-100 nm). [18][19][20][21][22] A promising candidate for drug delivery is lipid-polymer hybrid nanoparticles (LPHNPs), which have shown higher cellular delivery efficiency in vivo compared to the efficiencies obtained from polymeric and lipid NPs since the coating of the polymeric core with lipids prolongs their circulation time. LPHNPs delay polymer degradation and minimize the leakage of encapsulated content.…”
Section: Introductionmentioning
confidence: 99%
“…An essential characteristic of nanocarriers is the controlled release of the drug at the target site, achieved thanks to their small size (1–100 nm). 18–22…”
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment associated with the accumulation of beta-amyloid protein (Aβ). Aβ activates glial cells in the brain, increasing the secretion...
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