Nanocarriers for Diagnosis and Targeting of Breast Cancer

Abstract

Breast cancer nanotherapeutics is consistently progressing and being used to remove the various limitations of conventional method available for the diagnosis and treatment of breast cancer. Nanoparticles provide an interdisciplinary area for research in imaging, diagnosis, and targeting of breast cancer. With advanced physicochemical properties and better bioavailability, they show prolonged blood circulation with efficient tumor targeting. Passive targeting mechanisms by using leaky vasculature, tumor microenvironment, or direct local application and active targeting approaches using receptor antibody, amplification in the ability of nanoparticles to target specific tumor can be achieved. Nanoparticles are able to reduce cytotoxic effect of the active anticancer drugs by increasing cancer cell targeting in comparison to conventional formulations. Various nanoparticles-based formulations are in the preclinical and clinical stages of development; among them, polymeric drug micelles, liposomes, dendrimer, carbon nanotubes, and nanorods are the most common. In this review, we have discussed the role of nanoparticles with respect to oncology, by particularly focusing on the breast cancer and various nanodelivery systems used for targeting action.

Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells

“…Nanotechnologies offer promising approaches for the diagnosis and treatment of neoplastic disease, which remains a major on-going public health concern (Sharma et al, 2013).…”

Investigation of thermodynamic and structural properties of drug delivery system based on carbon nanotubes as a carboplatin drug carrier by molecular dynamics simulations

“…In recent years, carbon nanotubes (CNTs) have been envisioned in designing novel delivery platforms for medical applications due to their unique physical and chemical properties [1][2][3][4]. The physicochemical versatility of these nanomaterials is related to a large inner volume that can be filled with the desired chemical small molecules and multiple attachment sites for various functional groups along the nanotube axis [5][6][7].…”

PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway

“…NPs as carrier can reduce the cytotoxic side effects and achieve targeting chemotherapy. 22,23 We had previously evaluated the application of NPs and found that it would provide a promising strategy for chemotherapy. …”