Nanocarriers for photodynamic-gene therapy

Santana, Willian Max O.S. de; Surur, manda Koberstain; Momesso, Vinícius Medeiros; Lopes, Pedro Monteiro; Santilli, Chiara; Fontana, Carla Raquel

doi:10.1016/j.pdpdt.2023.103644

Cited by 4 publications

(1 citation statement)

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“…Therefore, comprehensive consideration of these factors to achieve the optimal outcome of PDT is important for the physician to make a treatment protocol. In addition, the combination of PDT with immune checkpoints, DC vaccines, and chemotherapy have been reported to effectively improve the immune effects of PDT [4,5]. Herein, we first analyze the mechanism and influence factors of anti-tumor immunity mediated by PDT.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies

Chou,

Sun,

Peng

et al. 2023

Pharmaceutics

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Photodynamic therapy (PDT) is an approved therapeutic procedure that exerts cytotoxic activity towards tumor cells by activating photosensitizers (PSs) with light exposure to produce reactive oxygen species (ROS). Compared to traditional treatment strategies such as surgery, chemotherapy, and radiation therapy, PDT not only kills the primary tumors, but also effectively suppresses metastatic tumors by activating the immune response. However, the anti-tumor immune effects induced by PDT are influenced by several factors, including the localization of PSs in cells, PSs concentration, fluence rate of light, oxygen concentration, and the integrity of immune function. In this review, we systematically summarize the influence factors of anti-tumor immune effects mediated by PDT. Furthermore, an update on the combination of PDT and other immunotherapy strategies are provided. Finally, the future directions and challenges of anti-tumor immunity induced by PDT are discussed.

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Section: Introductionmentioning

confidence: 99%