Nanocarriers for Resveratrol Delivery

Arora, Divya; Jaglan, Sundeep

doi:10.1007/978-3-319-58496-6_5

Cited by 10 publications

(5 citation statements)

References 62 publications

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“…Researchers have improved RES bioavailability via nanoencapsulation led to an increase in its water solubility and prevention of degradation. Nanoencapsulation also aided the reduction of RES-associated toxic effects in healthy tissues (Amri et al, 2012;Arora and Jaglan, 2017). Various nanomaterials have been reported for targeted drug delivery of RES (Peres et al, 2012;Khan et al, 2015;Ramalho and Pereira, 2016).…”

Section: Development Of An Effective Drug Delivery Systemmentioning

confidence: 99%

Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction

Yadav

Khan

et al. 2022

Front. Pharmacol.

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Most polyphenols can cross blood-brain barrier, therefore, they are widely utilized in the treatment of various neurodegenerative diseases (ND). Resveratrol, a natural polyphenol contained in blueberry, grapes, mulberry, etc., is well documented to exhibit potent neuroprotective activity against different ND by mitochondria modulation approach. Mitochondrial function impairment is the most common etiology and pathological process in various neurodegenerative disorders, viz. Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. Nowadays these ND associated with mitochondrial dysfunction have become a major threat to public health as well as health care systems in terms of financial burden. Currently available therapies for ND are limited to symptomatic cures and have inevitable toxic effects. Therefore, there is a strict requirement for a safe and highly effective drug treatment developed from natural compounds. The current review provides updated information about the potential of resveratrol to target mitochondria in the treatment of ND.

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Section: Development Of An Effective Drug Delivery Systemmentioning

confidence: 99%

Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction

Yadav

Khan

et al. 2022

Front. Pharmacol.

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“…Nanoemulsions are developed by combining two immiscible phases, an aqueous phase and an oil phase, with emulsifiers such as surfactants and co-surfactants. Typical oil phases include captex 355, captex 8000, witepsol, myritol 318, capryol 90, sefsol 218, triacetin, isopropyl myristate, castor oil, and olive oil, while water is used as aqueous phase [85,86]. Emulsifiers play an essential role in nanoemulsion formulation, as they improve kinetic stability [87], interactions [88], and shelf-life [89], as well as reduce the interfacial tension between the two phases.…”

Section: Nanoemulsion-based Fertilizersmentioning

confidence: 99%

Nanofertilizers: Types, Delivery and Advantages in Agricultural Sustainability

Yadav

Abd-Elsalam

2023

Agrochemicals

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In an alarming tale of agricultural excess, the relentless overuse of chemical fertilizers in modern farming methods have wreaked havoc on the once-fertile soil, mercilessly depleting its vital nutrients while inflicting irreparable harm on the delicate balance of the surrounding ecosystem. The excessive use of such fertilizers leaves residue on agricultural products, pollutes the environment, upsets agrarian ecosystems, and lowers soil quality. Furthermore, a significant proportion of the nutrient content, including nitrogen, phosphorus, and potassium, is lost from the soil (50–70%) before being utilized. Nanofertilizers, on the other hand, use nanoparticles to control the release of nutrients, making them more efficient and cost-effective than traditional fertilizers. Nanofertilizers comprise one or more plant nutrients within nanoparticles where at least 50% of the particles are smaller than 100 nanometers. Carbon nanotubes, graphene, and quantum dots are some examples of the types of nanomaterials used in the production of nanofertilizers. Nanofertilizers are a new generation of fertilizers that utilize advanced nanotechnology to provide an efficient and sustainable method of fertilizing crops. They are designed to deliver plant nutrients in a controlled manner, ensuring that the nutrients are gradually released over an extended period, thus providing a steady supply of essential elements to the plants. The controlled-release system is more efficient than traditional fertilizers, as it reduces the need for frequent application and the amount of fertilizer. These nanomaterials have a high surface area-to-volume ratio, making them ideal for holding and releasing nutrients. Naturally occurring nanoparticles are found in various sources, including volcanic ash, ocean, and biological matter such as viruses and dust. However, regarding large-scale production, relying solely on naturally occurring nanoparticles may not be sufficient or practical. In agriculture, nanotechnology has been primarily used to increase crop production while minimizing losses and activating plant defense mechanisms against pests, insects, and other environmental challenges. Furthermore, nanofertilizers can reduce runoff and nutrient leaching into the environment, improving environmental sustainability. They can also improve fertilizer use efficiency, leading to higher crop yields and reducing the overall cost of fertilizer application. Nanofertilizers are especially beneficial in areas where traditional fertilizers are inefficient or ineffective. Nanofertilizers can provide a more efficient and cost-effective way to fertilize crops while reducing the environmental impact of fertilizer application. They are the product of promising new technology that can help to meet the increasing demand for food and improve agricultural sustainability. Currently, nanofertilizers face limitations, including higher costs of production and potential environmental and safety concerns due to the use of nanomaterials, while further research is needed to fully understand their long-term effects on soil health, crop growth, and the environment.

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“…Moreover, the metabolism of Res is extremely rapid and extensive, resulting in a short plasma half-life [36] . It is therefore no surprise that a number of studies have focused on the preparation of nanomicelles of these compounds in order to improve their solubilities [4] . Several types of polymers were investigated for solubility improvement of Res, including Pluronic [1 , 2 , 12 , 17 , 25 , 33] .…”

Section: Introductionmentioning

confidence: 99%

Validated HPLC method for simultaneous quantitative determination of dimethylcurcumin and resveratrol in pluronic-F127 nanomicelles: Formulation with enhanced anticancer efficacy

Arakkunakorn,

Pholthien,

Sajomsang

et al. 2023

MethodsX

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Nanocarriers for Resveratrol Delivery

Cited by 10 publications

References 62 publications

Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction

Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction

Nanofertilizers: Types, Delivery and Advantages in Agricultural Sustainability

Validated HPLC method for simultaneous quantitative determination of dimethylcurcumin and resveratrol in pluronic-F127 nanomicelles: Formulation with enhanced anticancer efficacy

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