Nanocarriers for topical administration of resveratrol: A comparative study

Scognamiglio, Immacolata; Stefano, Daniela De; Campani, Virginia; Mayol, Laura; Carnuccio, Rosa; Fabbrocini, Gabriella; Ayala, Fabio; Rotonda, Maria Immacolata La; Rosa, Giuseppe De

doi:10.1016/j.ijpharm.2012.08.009

Cited by 135 publications

(74 citation statements)

References 38 publications

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“…This may be attributed to the fusion of these vesicles with skin lipids and the active release along the penetration pathway, resulting in a depot effect. In particular, this effect could be higher in the presence of ethanol 22,23,[37][38][39] which increases the skin permeability by intercalation into the polar head group of skin lipids. The synergistic mechanism between ethanol, surfactant, vesicles, and skin lipids is responsible for a higher skin penetration of transethosomes.…”

Section: Permeation and Penetration Studiesmentioning

confidence: 99%

Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes

Ascenso¹,

Raposo²,

Batista³

et al. 2015

IJN

263

150

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Ultradeformable vesicles (UDV) have recently become a promising tool for the development of improved and innovative dermal and transdermal therapies. The aim of this work was to study three related UDV: transfersomes, ethosomes, and transethosomes for the incorporation of actives of distinct polarities, namely, vitamin E and caffeine, and to evaluate the effect of the carrier on skin permeation and penetration. These actives were incorporated in UDV formulations further characterized for vesicles imaging by transmission electron microscopy; mean vesicle size and polydispersity index by photon correlation spectroscopy; zeta potential by laser-Doppler anemometry; deformability by pressure-driven transport; and incorporation efficiency (IE) after actives quantification by high-performance liquid chromatography. Topical delivery studies were performed in order to compare UDV formulations regarding the release, skin permeation, and penetration profiles. All UDV formulations showed size values within the expected range, except transethosomes prepared by “transfersomal method”, for which size was smaller than 100 nm in contrast to that obtained for vesicles prepared by “ethosomal method”. Zeta potential was negative and higher for formulations containing sodium cholate. The IE was much higher for vitamin E- than caffeine-loaded UDV as expected. For flux measurements, the following order was obtained: transethosomes (TE) > ethosomes (E) ≥ transfersomes (T). This result was consistent with the release and skin penetration profiles for Vitamin E-loaded UDV. However, the releasing results were totally the opposite for caffeine-loaded UDV, which might be explained by the solubility and thermodynamic activity of this active in each formulation instead of the UDV deformability attending to the higher non-incorporated fraction of caffeine. Anyway, a high skin penetration and permeation for all caffeine-loaded UDV were obtained. Transethosomes were more deformable than ethosomes and transfersomes due to the presence of both ethanol and surfactant in their composition. All these UDV were suitable for a deeper skin penetration, especially transethosomes.

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Section: Permeation and Penetration Studiesmentioning

confidence: 99%

Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes

Ascenso¹,

Raposo²,

Batista³

et al. 2015

IJN

263

150

View full text Add to dashboard Cite

show abstract

“…Among large number of the available references we have chosen to select and present several examples from each delivery system (Table 3). Scognamiglio et al (2013) evaluated the penetration potential of deformable liposomes and ethosomes containing resveratrol using freshly excised pig ear. The deformable liposomes decreased the amount of resveratrol accumulated in dermis as compared to ethosomes.…”

Section: Porcine Skinmentioning

confidence: 99%

In vitro skin models as a tool in optimization of drug formulation

Flaten

Palac²,

Engesland

et al. 2015

European Journal of Pharmaceutical Sciences

182

135

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Abstract(Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the product development. A rational approach in designing and optimizing skin formulations requires well-defined skin models, able to identify and evaluate the intrinsic properties of the formulation. Most of the current optimization relies on the use of suitable ex vivo animal/human models.However, increasing restrictions in use and handling of animals and human skin stimulated the search for suitable artificial skin models. This review attempts to provide an unbiased overview of the most commonly used models, with emphasis on their limitations and advantages. The choice of the most applicable in vitro model for the particular purpose should be based on the interplay between the availability, easiness of the use, cost and the respective limitations.

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“…To overcome this, nanodelivery techniques such as solid lipid nanoparticles, nanoemulsions, and transfersomes showed enhanced resveratrol stability and delivery to the skin. 136,307,308 Recently, microemulsions were constructed using resveratrol with particle sizes of 66-68 nm that enhanced resveratrol bioavailability to the skin to protect against UV radiation. 309 Recently, three different nanodelivery techniques, such as solid lipid nanocarrier, nanostructured lipid carrier, and nanoemulsions, were studied for resveratrol delivery efficiency to the skin.…”

Section: Nanoresveratrolmentioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

147

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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Nanocarriers for topical administration of resveratrol: A comparative study

Cited by 135 publications

References 38 publications

Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes

Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes

In vitro skin models as a tool in optimization of drug formulation

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

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