Nanocarriers in cancer clinical practice: a pharmacokinetic issue

Giodini, Luciana; Re, Francesco Lo; Campagnol, Davide; Marangon, Elena; Posocco, Bianca; Dreussi, Eva; Toffoli, Giuseppe

doi:10.1016/j.nano.2016.07.012

Cited by 53 publications

(26 citation statements)

References 106 publications

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“…Considering the rapid advancement in nanotechnology in the last few years, innovated strategies have been implemented to influence the disposition and efficiency of drugs through the use of nanocarriers. Nanocarrier-based delivery systems decrease systemic toxicity, maintain controlled and sustained release of drugs, and overlap drug resistance (Giodini et al, 2017). Biodegradable polymeric nanocarriers, such as polylactic-co-glycolic acid; PLGA), have emerged as a versatile carrier system for targeted delivery of anti-cancer drugs owing to its great biocompatibility and biodegradability.…”

Section: Improving Anti-cancer Potentiality and Bioavailability Of Gallic Acid By Designing Polymeric Nanocomposite Formulationmentioning

confidence: 99%

Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation

Ahmed

Galal

Shalby

et al. 2018

Asian Pac J Cancer Prev

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Objective:In this study, we investigated the in vivo antitumor activity and pharmacokinetic characteristics of encapsulated GA-NC (gallic acid nanocomposite) in normal and hepatocellular carcinoma (HCC)-induced rats.Methods:Rats were distributed into 4 groups; negative control, HCC, gallic acid (GA), and GA-NC. Serum levels of alpha-fetoprotein (AFP), endoglin (ENG), heat shock protein-70 (HSP-70), pro-caspase 3, lipocalin-2 (LCN-2) and β-cell leukemia/lymphoma 2 (Bcl-2) were assayed by ELISA. The pharmacokinetic parameters for GA or GA-NC were determined by means of non-compartmental approach based on the serum– concentration profiles of free GA and GA-NC after oral administration. Also, histological procedures were used for examination of liver tissue sections.Results:Anaplastic changes in liver tissues were observed in untreated HCC group, as well as a significant increase in the serum AFP level. In addition, significant elevation in the serum ENG level as an angiogenic marker and the serum levels of the apoptotic mediators; HSP-70, Bcl-2 and pro-caspase 3 beside significant amplification in the serum inflammatory modulator, LCN-2 were recorded. Treatment with free GA or GA-NC markedly recovered the anaplastic changes in the rat liver tissues. In addition, they restored serum levels of AFP, ENG, HSP-70, Bcl-2, pro-caspase-3, and LCN-2. Pharmacokinetic analysis revealed that GA–NC displayed a characteristic sustained release profile with 4-fold increase in bioavailability in normal and HCC-induced rats.Conclusions:The results of this study suggest that encapsulation of GA into PLGA-CS-PEG enhances its oral bioavailability and anti-cancer activity. GA-NC may be a new therapeutic candidate for the mitigation of hepatocarcinogenesis.

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Section: Improving Anti-cancer Potentiality and Bioavailability Of Gallic Acid By Designing Polymeric Nanocomposite Formulationmentioning

confidence: 99%

Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation

Ahmed

Galal

Shalby

et al. 2018

Asian Pac J Cancer Prev

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“…When designing a drug delivery system at the earliest stages, consideration must be given to several key factors that will dictate efficacy as a nanomedicine, including: how the drug or imaging agent will be formulated into the nanoparticle (Hare et al, 2017), how the delivery system will act when administered to cells or in vivo (Beck-Broichsitter, Nicolas, & Couvreur, 2015; Blanco, Shen, & Ferrari, 2015; Livney & Assaraf, 2013), and pharmacokinetic factors such as release kinetics and particle decomposition (Giodini et al, 2017; Wilhelm et al, 2016). Frequently, controlled release and targeted delivery are goals of using a nanoformulation and these outcomes can be influenced or designed through mathematical or computation methods.…”

Section: Introductionmentioning

confidence: 99%

The role of hydrophobic modification on hyaluronic acid dynamics and self-assembly

Payne

Svechkarev

Kyrychenko

et al. 2018

Carbohydrate Polymers

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The advent of nanomedicine has rejuvenated the need for increased understanding of the fundamental physicochemical properties of polymeric amphiphiles. Hyaluronic acid (HA) is a hydrophilic polysaccharide that is frequently conjugated to hydrophobic moieties and then used to entrap dyes and therapeutics. Here, we develop computational models to examine the effects of the hydrophobic modification on supramolecular behavior among three systematically designed HA derivatives substituted with alkyl chains of increasing length. Our simulations coalesce with experimentally obtained results to demonstrate the dependence of supramolecular behavior on intramolecular forces. We show that the formation of clearly defined hydrophobic domains in samples of octadecylamine-modified HA compared to HA conjugates with shorter alkyl chains is a result of more favorable hydrophobic interactions. Trends in hydrodynamic radius and polydispersity are observed in experimental results that coalesce with theoretical calculations, suggesting that supramolecular properties are dependent on the physicochemical characteristics of individual polymer strands.

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“…Nanoxel ® is another type of micelle-based formulation made up of pH-sensitive Nisopropyl acrylamide (NIPAM) polymerized with vinyl pyrrolidone (VP) [57]. The system was designed to selectively release the PTX when the pH reaches acidic values, as are found in the tissues of several types of solid tumors [58,59].…”

Section: Overview On Marketed Ptx-loaded Nanosystemsmentioning

confidence: 99%

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Voci

Gagliardi

Molinaro

et al. 2021

Gels

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The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol®), consistent efforts have been made to obtain suitable delivery systems able to preserve/increase PTX efficacy and to overcome the side effects correlated to the presence of some excipients. The exploitation of natural polymers as potential materials for drug delivery purposes has favored the modulation of the bioavailability and the pharmacokinetic profiles of the drug, and in this regard, several formulations have been developed that allow the controlled release of the active compound. In this mini-review, the recent advances concerning the design and applications of natural polymer-based hydrogels containing PTX-loaded biocompatible nanocarriers are discussed. The technological features of these formulations as well as the therapeutic outcome achieved following their administration will be described, demonstrating their potential role as innovative systems to be used in anti-tumor therapy.

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Nanocarriers in cancer clinical practice: a pharmacokinetic issue

Cited by 53 publications

References 106 publications

Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation

Improving Anti-Cancer Potentiality and Bioavailability of Gallic Acid by Designing Polymeric Nanocomposite Formulation

The role of hydrophobic modification on hyaluronic acid dynamics and self-assembly

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

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