Nanocarriers: Promising Vehicle for Bioactive Drugs

Rawat, Mamta; Singh, Deependra; Saraf, Swarnlata

doi:10.1248/bpb.29.1790

Cited by 395 publications

(240 citation statements)

References 110 publications

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“…1,2 Polymer nanoparticles (PN) are carriers of drugs or other active molecules whose sizes range from 10 to 1000 nm. Nanospheres (NS) or nanocapsules (NC) can be obtained, depending on the method of preparation and the materials employed.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical stability of poly(lactide-co-glycolide) nanocapsules containing the local anesthetic Bupivacaine

Moraes

Paula

Rosa

et al. 2010

J. Braz. Chem. Soc.

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Neste trabalho foi realizada a preparação de nanocápsulas de poli (DL-lactídeo-co-glicolídeo) (PLGA) como um sistema carreador para o anestésico local bupivacaína. A preparação foi caracterizada e sua estabilidade físico-química avaliada. Os resultados da caracterização mostram uma distribuição de tamanho com um índice de polidispersão de 0,12, um diâmetro médio de 148 nm, um potencial zeta de -43,5 mV e uma eficiência de associação da BVC nas nanocápsulas de 75,8%. As propriedades físico-químicas das suspensões (diâmetro hidrodinâmico, índice de polidispersão, potencial zeta e eficiência de associação do fármaco) contendo nanocápsulas poliméricas foram avaliadas em função do tempo a fim de determinar sua estabilidade. Nenhuma grande alteração foi observada em função tempo para as suspensões de nanocápsulas avaliadas, sendo consideradas estáveis por um período de armazenagem de 120 dias a temperatura ambiente. Os resultados aqui apresentados, os quais se referem ao estudo desta nova formulação para anestésico local bupivacaína mostram-se promissores para futuros estudos in vivo.This paper describes the preparation of poly(DL-lactide-co-glicolide) (PLGA) nanocapsules as a drug carrier system for the local anesthetic bupivacaine. The system was characterized and its stability investigated. The results showed a size distribution with a polydispersity index of 0.12, an average diameter of 148 nm, a zeta potential of -43.5 mV and an entrapment efficiency of 75.8%. The physicochemical properties of polymeric nanocapsule suspensions (average diameter, polydispersity, zeta potential and drug association efficiency) were evaluated as a function of time to determine the formulation stability. The formulation did not display major changes in these properties over the time, and it was considered stable up to 120 days of storage at room temperature. The results reported here which refer to the initial characterization of these new formulations for the local anesthetic bupivacaine show a promising potential for future in vivo studies.Keywords: bupivacaine, local anesthetic, polymeric nanocapsules, PLGA, physical-chemical stability IntroductionNumerous studies today are focusing on the development of new pharmaceutical formulations based on nanocarriers, which have demonstrated several advantages over conventional formulations, making this research line a promising and innovative area of the pharmaceutical sector. 1,2Polymer nanoparticles (PN) are carriers of drugs or other active molecules whose sizes range from 10 to 1000 nm. Nanospheres (NS) or nanocapsules (NC) can be obtained, depending on the method of preparation and the materials employed. NC consists of a polymer casing and a nucleus (usually oily). The drug inside the NC may be dissolved in the oily nucleus or adsorbed on the polymeric wall. NS, on the other hand, consists of a polymer matrix and their composition does not include oil. In this system, the drug may be adsorbed or dispersed in the polymeric matrix. [2][3][4][5][6] Several polymers are used in the prepa...

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Section: Introductionmentioning

confidence: 99%

Physicochemical stability of poly(lactide-co-glycolide) nanocapsules containing the local anesthetic Bupivacaine

Moraes

Paula

Rosa

et al. 2010

J. Braz. Chem. Soc.

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“…Ceramic nanoparticles are particles fabricated from inorganic compounds with porous characteristics such as silica, alumina and titania [55][56][57] . They can be prepared with the desired size, shape and porosity.…”

Section: Ceramic Nanoparticlesmentioning

confidence: 99%

“…Their sizes are less than 100nm and are able to avoid uptake by the reticulo-endothelial system as foreign bodies. Entrapped molecules such as drugs, proteins and enzymes are protected from denaturation at physiological pH and temperature as neither swelling nor change in porosity occurs 57 . Hence, they are effective in delivering proteins and genes.…”

Section: Ceramic Nanoparticlesmentioning

confidence: 99%

Nanotechnology and Drug Delivery Part 2: Nanostructures for Drug Delivery

Ochekpe¹,

Olorunfemi²,

Ngwuluka³

2009

Trop. J. Pharm Res

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“…Polymeric nanoparticles that bind to peptides can be used for oral delivery and also to increase the absorption and bioavailability. In addition, the method of production in this case can be performed on a large scale [13]. The most commonly used natural polymers in the preparation of polymeric nanoparticles are chitosan, gelatin, sodium alginate, and albumin [14].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Nanoparticles Produced by Chloroform Fraction of Kaempferia Rotunda Rhizome Loaded With Alginic Acid and Chitosan and Its Biological Activity Test

Atun

Arianingrum

2017

Asian J Pharm Clin Res

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Objective: The main objectives of this research are to characterize the nanoparticles produced by chloroform fraction of Kaempferia rotunda loaded with alginic acid and combination of alginic acid-chitosan, and its biological activity test.Methods: Chloroform fraction of K. rotunda was loaded on alginic acid and combination of alginic acid-chitosan nanoparticles by ionic gelation method in various compositions. Characterizations of the products were investigated in particle size, zeta potential, and morphology by scanning electron microscopy (SEM). The biological activity of the products as an antioxidant was tested by the 2,2-diphenyl-1-picrylhydrazyl method. The cytotoxic effect was analyzed using 3-(4,5 dimethyltiazol-2-yl)-2,5-diphenyltetrazoilium bromide assay. Result:The alginic acid nanoparticles can be synthesized at the optimal mass ratio range of alginic acid:CaCl 2 of 10:1 (% w/v), while the combination of alginic acid-chitosan nanoparticle at the optimal mass ratio range of alginic acid:chitosan of 10:1 (% w/v) and added calcium ion at 0.015% w/v. Antioxidant activity from alginic acid nanoparticle; combination of alginic acid-chitosan nanoparticle; and chloroform fraction from K. rotunda showed inhibition activity (IC 50 ): 225.63±3.5, 237.12±2.1, and 25.20±1.3 mg/mL, respectively, whereas the cytotoxic effect against human breast cancer T47D from these compounds showed IC 50: 145.25±2.2, 281.21±2.3, and 41.72±0.47 µg/mL, respectively. Conclusion:The nanoparticle products of chloroform fraction from K. rotunda loaded alginic acid and combination alginic acid-chitosan were successfully obtained by ionic gelation method. The nanoparticle products show lower activity in antioxidant and cytotoxic effects against human breast cancer T47D cell lines than the starting material chloroform fraction of K. rotunda.

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Nanocarriers: Promising Vehicle for Bioactive Drugs

Cited by 395 publications

References 110 publications

Physicochemical stability of poly(lactide-co-glycolide) nanocapsules containing the local anesthetic Bupivacaine

Physicochemical stability of poly(lactide-co-glycolide) nanocapsules containing the local anesthetic Bupivacaine

Nanotechnology and Drug Delivery Part 2: Nanostructures for Drug Delivery

Characterization of Nanoparticles Produced by Chloroform Fraction of Kaempferia Rotunda Rhizome Loaded With Alginic Acid and Chitosan and Its Biological Activity Test

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