Nanocellulose-based hydrogels for drug delivery

Ai, Yusen; Lin, Zhongxin; Zhao, Wenqi; Cui, Mei; Qi, Wei; Huang, Renliang; Su, Rongxin

doi:10.1039/d3tb00478c

Cited by 20 publications

(6 citation statements)

References 180 publications

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“…Hydrogels represent a class of polymeric biomaterials that have garnered considerable attention in the field of drug delivery and biomedical applications due to their unique characteristics. These three-dimensional networks consist of hydrophilic polymer chains, which imbue them with a high water content, typically ranging from 90 % to 99 % [ 32 ]. This remarkable feature renders hydrogels highly biocompatible and well-tolerated by living tissues, making them particularly suitable for a wide array of medical applications.…”

Section: Different Types Of Polymeric Ddsmentioning

confidence: 99%

Polymeric biomaterials: Advanced drug delivery systems in osteoarthritis treatment

Liu,

Tang,

Wang

2023

Heliyon

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Section: Different Types Of Polymeric Ddsmentioning

confidence: 99%

Polymeric biomaterials: Advanced drug delivery systems in osteoarthritis treatment

Liu,

Tang,

Wang

2023

Heliyon

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“…The drug delivery capacity of implantable materials is an important factor in improving their performance. For effective drug delivery, the introduction of mediators such as drug carriers and hydrogels or physical methods such as creating micropores on a material surface have been investigated [5][6][7][8]. In particular, to store and deliver drugs, it has been reported that micropores can be formed on the material surface using laser-based physical surface modification methods such as ion beam and femtosecond laser irradiation or chemical surface modification methods such as anodic oxidation and polishing [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Drug release control and anti-inflammatory effect of biodegradable polymer surface modified by gas phase chemical functional reaction

Bae,

Kim

2024

Biomed. Mater.

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The plasma technique has been widely used to modify the surfaces of materials. The purpose of this study was to evaluate the probability of controlling the prednisolone delivery velocity on a polylactic acid (PLA) surface modified by plasma surface treatment. Surface modification of PLA was performed at a low-pressure radio frequency under conditions of 100 W power, 50 mTorr chamber pressure, 100~200 sccm of flow rate, and Ar, O2, and CH4 gases. The plasma surface-modified PLA was characterized using scanning emission microscope, X-ray photoelectron spectroscopy (XPS), and contact angle measurements. In vitro evaluations were performed to determine cellular response, drug release behavior, and anti-inflammatory effects. The PLA surface morphology was changed to a porous structure (with a depth of approximately 100 μm) and the surface roughness was also significantly increased. The XPS results demonstrated higher oxygenized carbon contents than those in the non-treated PLA group. The prednisolone holding capacity increased and the release was relatively prolonged in the surface-modified PLA group compared to that in the non-treated PLA group. In addition, cell migration and proliferation significantly increased after PLA treatment alone. The activity of cytokines such as COX-2, TNF-α, IL-1β, and IL-6 were considerably reduced in the plasma-treated and prednisolone holding group. Taken together, surface-modified PLA by plasma can provide an alternative approach to conventional physicochemical approaches for sustained anti-inflammatory drug release.

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“…have been reported, which is expected to heighten the efficacy and safety of DOX. − Despite significant advancements, simple delivery systems could be prone to causing premature drug leakage, failing to achieve an effective drug therapeutic concentration at the focal site. Besides, these delivery systems often require complicated synthetic materials, which may bring about a tedious preparation process and increase the cost. − Therefore, there remains a surging anticipation for developing a novel simple and effective delivery strategy for HCC therapy.…”

Section: Introductionmentioning

confidence: 99%

Composite Microparticles from Microfluidics for Chemo-/Photothermal Therapy of Hepatocellular Carcinoma

Xu,

Wang,

Fan

et al. 2024

ACS Appl. Mater. Interfaces

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Hydrogel microcarrier-based drug delivery systems are of great value in the combination therapy of tumors. Current research directions concentrate on the development of more economic, convenient, and effective combined therapeutic platforms. Herein, we developed novel adhesive composite microparticles (MP PMD ) with combined chemo-and photothermal therapy ability via microfluidic electrospray technology for local hepatocellular carcinoma treatment. These composite microparticles consisted of doxorubicin (DOX)-loaded and polydopamine-wrapped mesoporous silicon and alginate. Benefiting from such a strategy of hierarchical structure drug loading, DOX could be gradually released from the system, effectively avoiding the direct toxicity of chemotherapeutics to the body. Additionally, the designed microparticles could not only effectively treat tumors by releasing the chemotherapy drug DOX but also show excellent photothermal properties under the irradiation of near-infrared light, achieving combined chemo-and photothermal treatment effects. Based on these advantages, the MP PMD could remarkably eliminate tumor cells in vitro and enormously restrict tumor development in vivo. These results illustrate that such composite microparticles are ideal combination treatment platforms, possessing promising expectations for cancer therapy.

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Nanocellulose-based hydrogels for drug delivery

Abstract: This article presents a comprehensive review of the preparation methods, carrier forms, and key parameters of nanocellulose-based hydrogels as drug delivery systems. And it proposes potential research directions.

Cited by 20 publications

References 180 publications

Polymeric biomaterials: Advanced drug delivery systems in osteoarthritis treatment

Polymeric biomaterials: Advanced drug delivery systems in osteoarthritis treatment

Drug release control and anti-inflammatory effect of biodegradable polymer surface modified by gas phase chemical functional reaction

Composite Microparticles from Microfluidics for Chemo-/Photothermal Therapy of Hepatocellular Carcinoma

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