Nanocellulose-Based Interpenetrating Polymer Network (IPN) Hydrogels for Cartilage Applications

Naseri, Narges; Deepa, B.; Mathew, Aji P.; Oksman, Kristiina; Girandon, Lenart

doi:10.1021/acs.biomac.6b01243

Cited by 169 publications

(111 citation statements)

References 52 publications

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“…The scaffolds were printed in dimensions of 2 × 2 × 2 cm 3 with pore size of 1 mm and pore wall thickness of 0.5 mm ( Figure ). Additional polymers (e.g., alginate) and divalent cations (Ca 2+ ) were used to stabilize the 3D printed structures through fast ionic crosslinking . The ZIF‐8 loading, up to a certain limit, improved the rheological properties (Figure ).…”

Section: Resultssupporting

confidence: 81%

CelloMOF: Nanocellulose Enabled 3D Printing of Metal–Organic Frameworks

Sultan

Abdelhamid

Zou

et al. 2018

Adv Funct Materials

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175

126

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3D printing is recognized as a powerful tool to develop complex geometries for a variety of materials including nanocellulose. Herein, a one-pot synthesis of 3D printable hydrogel ink containing zeolitic imidazolate frameworks (ZIF-8) anchored on anionic 2,2,6,6-tetramethylpiperidine-1-oxylradicalmediated oxidized cellulose nanofibers (TOCNF) is presented. The synthesis approach of ZIF-8@TOCNF (CelloZIF8) hybrid inks is simple, fast (≈30 min), environmentally friendly, takes place at room temperature, and allows easy encapsulation of guest molecules such as curcumin. Shear thinning properties of the hybrid hydrogel inks facilitate the 3D printing of porous scaffolds with excellent shape fidelity. The scaffolds show pH controlled curcumin release. The synthesis route offers a general approach for metal-organic frameworks (MOF) processing and is successfully applied to other types of MOFs such as MIL-100 (Fe) and other guest molecules as methylene blue.This study may open new venues for MOFs processing and its large-scale applications.

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Section: Resultssupporting

confidence: 81%

CelloMOF: Nanocellulose Enabled 3D Printing of Metal–Organic Frameworks

Sultan

Abdelhamid

Zou

et al. 2018

Adv Funct Materials

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175

126

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“…We have reported in the recent years scaffolds, implants and wound dressing materials based on nanocellulose and nanochitin as reinforcements in biopolymers prepared via casting, electrospinning or freeze-drying processes. [5][6][7][8][9] These studies demonstrated nanostructured and cytocompatible scaffolds with high porosity, nanoscaled pore wall roughness, pore interconnectivity and wet mechanical properties suitable for biomedical applications. However, an accurate control of the pore sizes was not achieved through these processing techniques.…”

Section: Introductionmentioning

confidence: 88%

3D printed scaffolds with gradient porosity based on a cellulose nanocrystal hydrogel

2018

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3-Dimensional (3D) printing provides a unique methodology for the customization of biomedical scaffolds with respect to size, shape, pore structure and pore orientation useful for tissue repair and regeneration. 3D printing was used to fabricate fully bio-based porous scaffolds of a double crosslinked interpenetrating polymer network (IPN) from a hydrogel ink of sodium alginate and gelatin (SA/G) reinforced with cellulose nanocrystals (CNCs). CNCs provided favorable rheological properties required for 3D printing. The 3D printed scaffolds were crosslinked sequentially via covalent and ionic reactions resulting in dimensionally stable hydrogel scaffolds with pore sizes of 80-2125 μm and nanoscaled pore wall roughness (visible from scanning electron microscopy) favorable for cell interaction. The 2D wide angle X-ray scattering studies showed that the nanocrystals orient preferably in the printing direction; the degree of orientation varied between 61-76%. The 3D printing pathways were optimised successfully to achieve 3-dimensional scaffolds (Z axis up to 20 mm) with uniform as well as gradient pore structures. This study demonstrates the potential of 3D printing in developing bio-based scaffolds with controlled pore sizes, gradient pore structures and alignment of nanocrystals for optimal tissue regeneration.

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“…Aarstad et al 91 prepared CaCO 3 /D-glucono-δ-lactone modified alginate hydrogels containing CNFs and cross-linked with CaCl 2 that showed a high elastic modulus value. Naseri et al 92 developed double-network hydrogels with alginate and gelatin also containing 50% CNCs. The hydrogel presented an elastic modulus value of 0.5 GPa, a mechanical strength of 14.4 MPa and a deformation of 15.2%.…”

Section: Alginatementioning

confidence: 99%