Nanocellulose-based sensors in medical/clinical applications: The state-of-the-art review

Langari, Mahsa Mousavi; Nikzad, Maryam; Labidi, Jalel

doi:10.1016/j.carbpol.2022.120509

Cited by 20 publications

(6 citation statements)

References 139 publications

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“…Most of these electronic devices such as portable computers, digital cameras, mobile phones, tablets, electronic watches, and Bluetooth speakers are equipped with sensors. Sensors are analytical instruments that respond to different stimulating factors and are situated to recognize external factors for example light, motion, humidity, temperature, sound, or chemicals [ 95 ]. Sensors have been categorized by the International Union of Pure and Applied Chemistry (IUPAC) into three groups: physical sensors, chemical sensors and biosensors [ 96 ].…”

Section: Lignocellulosic Materials Based Sensorsmentioning

confidence: 99%

Lignocellulosic Bionanomaterials for Biosensor Applications

et al. 2023

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The rapid population growth, increasing global energy demand, climate change, and excessive use of fossil fuels have adversely affected environmental management and sustainability. Furthermore, the requirements for a safer ecology and environment have necessitated the use of renewable materials, thereby solving the problem of sustainability of resources. In this perspective, lignocellulosic biomass is an attractive natural resource because of its abundance, renewability, recyclability, and low cost. The ever-increasing developments in nanotechnology have opened up new vistas in sensor fabrication such as biosensor design for electronics, communication, automobile, optical products, packaging, textile, biomedical, and tissue engineering. Due to their outstanding properties such as biodegradability, biocompatibility, non-toxicity, improved electrical and thermal conductivity, high physical and mechanical properties, high surface area and catalytic activity, lignocellulosic bionanomaterials including nanocellulose and nanolignin emerge as very promising raw materials to be used in the development of high-impact biosensors. In this article, the use of lignocellulosic bionanomaterials in biosensor applications is reviewed and major challenges and opportunities are identified.

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Section: Lignocellulosic Materials Based Sensorsmentioning

confidence: 99%

Lignocellulosic Bionanomaterials for Biosensor Applications

et al. 2023

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“…These nanocellulose materials are low-cost and have high surface areas, which allow for a greater number of binding sites for biological molecules with higher specificity and sensitivity. The number of functional properties uncovered for nanocellulose’s use as a sensor transducer surface has grown in recent years to include a range of mechanical and molecular design motifs and sensitivities. , Nanocellulose has been a platform for biosensing, drug delivery, and tissue engineering singularly or in combination with other molecules and polymers. − Recent improvements on the biocompatible properties of nanocellulose for use in biological systems have been reported, and numerous efforts continue to elucidate its potential as a wearable sensor for use in diagnostic, drug delivery and medical applications as “intelligent dressings”. , …”

Section: Introductionmentioning

confidence: 99%

Assessment of Cellulose Nanofiber-Based Elastase Biosensors to Inflammatory Disease as a Function of Spacer Length and Fluorescence Response

Easson,

Jordan,

Edwards

et al. 2024

ACS Appl. Bio Mater.

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Inflammatory disease biomarker detection has become a high priority in point-of-care diagnostic research in relation to chronic wounds, with a variety of sensor-based designs becoming available. Herein, two primary aspects of biosensor design are examined: (1) assessment of a cellulose nanofiber (CNF) matrix derived from cotton ginning byproducts as a sensor transducer surface; and (2) assessment of the relation of spacer length and morphology between the CNF cellulose backbone and peptide fluorophore as a function of sensor activity for porcine pancreatic and human neutrophil elastases. X-ray crystallography, specific surface area, and pore size analyses confirmed the suitability of CNF as a matrix for wound care diagnostics. Based upon the normalized degree of substitution, a pegylated-linker connecting CNF transducer substrate to peptide fluorophore showed the greatest fluorescence response, compared to short-and long-chain alkylated linkers.

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“…The nanofibrous cellulose sheet not only offers all the advantages of conventional paper-based biosensors but this is also devoid of surface roughness, optical opaqueness, increased thermal expandability, and inability to fold. One of its several noteworthy applications includes the accurate and precise detection of S. aureus bacterial species for any infectious disease [10]. This article, however, gives an overview of the sources and extraction procedure of nano cellulose in its various forms along with its multidimensional usage.…”

Section: Introductionmentioning

confidence: 99%

Sources and Applications of Nano Cellulose Tailored Materials

Das Kirtania,

Chakraborty,

Barik

et al. 2024

Nanotechnology and Nanomaterials

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Cellulose is one of the most economical, biodegradable, and biosafe components found in nature. It is extracted from biomass found in forests or crops being treated enzymatically, chemically or mechanically. The extracted cellulose on acid hydrolysis and other mechanical treatment yields bacterial cellulose, nano-fibrillated cellulose, and cellulose nanocrystals. Nanosized cellulose can be attributed to the size reduction of the polymer chains in cellulose from micro to nanoscale. The size range was found suitable from 1–100 nm to be called nanosized cellulose. Nano cellulose hogged much limelight in the modern era due to its low toxicity, biocompatibility, and biodegradability. Due to the rapid evolution in this field, it is an obvious need to synthesize nano cellulose from different sources for its huge potential in pharmaceuticals and other industries. The tiny size made the nano cellulose mechanically strong and stable thus rendering it suitable for application, especially in pharmaceuticals, drug delivery, tissue engineering, and regenerative medicine. Recent research has been focused on the development and applications of nanocellulose products due to their eco-friendly nature and diversity of its application. However, there are challenges too, related to its scale-up, cost, and stability may be registered. This chapter will further discuss in detail the synthesis and preparations of nanosized cellulose and its theragnostic applications.

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Nanocellulose-based sensors in medical/clinical applications: The state-of-the-art review

Cited by 20 publications

References 139 publications

Lignocellulosic Bionanomaterials for Biosensor Applications

Lignocellulosic Bionanomaterials for Biosensor Applications

Assessment of Cellulose Nanofiber-Based Elastase Biosensors to Inflammatory Disease as a Function of Spacer Length and Fluorescence Response

Sources and Applications of Nano Cellulose Tailored Materials

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