Nanocellulose composite wound dressings for real-time pH wound monitoring

Eskilson, Olof; Zattarin, Elisa; Berglund, Linn; Oksman, Kristiina; Hanna, Kristina; Rakar, Jonathan; Sivlér, Petter; Skog, Mårten; Rinklake, Ivana; Shamasha, Rozalin; Sotra, Zeljana; Starkenberg, Annika; Odén, Magnus; Wiman, Emanuel; Khalaf, Hazem; Bengtsson, Torbjörn; Junker, Johan P.E.; Selegård, Robert; Björk, Emma M.; Aili, Daniel

doi:10.1016/j.mtbio.2023.100574

Cited by 38 publications

(20 citation statements)

References 63 publications

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“…For instance, F et al [64] incorporated the pH indicator phenol red dye into a hydrogel to monitor wound healing through color changes due to pH shifts. O et al recently demonstrated a novel approach for incorporating pH-sensing capabilities into a cutting-edge hydrogel wound dressing composed of bacterial nanocellulose (BC) [65]. In their study, they utilized mesoporous silica nanoparticles (MSN) to create a high surface area material in BC and then incorporated pH-responsive dyes into MSN to produce continuous pH-sensing wound dressings with spatiotemporal resolution.…”

Section: Ph-responsive For Hydrogel Dressingsmentioning

confidence: 99%

Functional hydrogel dressings for wound management: a comprehensive review

Fu,

Zheng,

Wen

et al. 2023

Mater. Res. Express

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Hydrogels have gained significant attention as wound dressings due to their potential for rapid healing. Researchers have actively explored a range of techniques for antimicrobial applications, including incorporating drug payloads, utilizing inorganic nanometals, and harnessing the properties of natural cationic polymers. In terms of hemostasis and coagulation promotion, techniques such as drug delivery, adhesive physical hemostasis, and adhesive functional groups have been studied. To control inflammation, researchers have investigated the application of natural antioxidants and antioxidant functional groups, which have demonstrated anti-inflammatory effects. Furthermore, the smart responsiveness of hydrogel wound dressings to pH, temperature, and light has been explored. This review presents a summary of the research progress and application prospects in these areas and offers an outlook on the future development direction of hydrogel wound dressings.

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Section: Ph-responsive For Hydrogel Dressingsmentioning

confidence: 99%

Functional hydrogel dressings for wound management: a comprehensive review

Fu,

Zheng,

Wen

et al. 2023

Mater. Res. Express

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“…Alkaline environment stimulates protease activation, resulting in an excess of protease, which ultimately causes the destruction of newly formed tissues. 16,17 In addition, a high alkaline pH creates an optimal environment for the proliferation of bacteria. 18 Therefore, it is imperative to restore the naturally acidic environment of the skin to facilitate cell proliferation and self-healing.…”

Section: Introductionmentioning

confidence: 99%

Fluorinated Peptide Nanoscale Hydrogel Accelerates Wound Healing via pH and Oxygen Microenvironment Regulation

Mei,

Yang,

Dong

et al. 2024

ACS Appl. Nano Mater.

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The abnormal levels of pH and oxygen (O 2 ) in the wound microenvironment impeded wound healing, and their regulation remains a challenge. Thus, a wound dressing with pH and O 2 -regulating capacity is urgently desired. Here, we designed and prepared a fluorinated peptide hydrogel wound dressing to regulate the pH and O 2 microenvironment of the wound site. Fluorinated peptides with the (naphthalene-2-ly)-Gly-5f Phe-5f Phe-Tyr-Arg-Gly-Asp sequence (F 5 −Pep) could self-assemble to a nanofiber network in a weak acidic buffer (pH = 6.0), which is similar to the pH of human skin. The F 5 −Pep hydrogel can maintain pH levels at 6.0−7.3 for 24 h and continuously release O 2 for 4 h. The blood coagulation and hemostasis assay showed that the F 5 −Pep hydrogel significantly accelerated blood clotting speed in vitro and rapidly controlled hemorrhage in a mouse liver hemorrhage model. In vitro cell migration assays and in vivo animal experiments confirmed that the F 5 −Pep hydrogel can promote cell migration and wound healing. In summary, this work might provide an effective treatment strategy for wounds and develop advanced wound-healing materials.

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“…[10] Cellulose fibrils can be treated chemically and mechanically to produce nanofibrillated cellulose (NFC) that consists of nano-sized fibrils with diameters of less than 20 nm and varying lengths up to several micrometers. There are several examples in the literature where cellulose is combined with synthetic materials [11,12] such as inorganic nanoparticles, [13] ionic liquids, [14] carbon nanotubes, [15] and conducting polymers [16] for applications in non-traditional areas such as energy [17] and biomedical devices, [18] water treatment, [19] optical metamaterials, [20,21] and smart textiles. [22,23] Specifically, the conducting polymer poly(3,4ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), has been widely used in composites with cellulose [16] due to its high electronic and ionic conductivity, [24] high specific capacitance, and thermoelectric properties enabling the formation of active materials for supercapacitors, [25][26][27][28][29][30] thermoelectric generators, [31] sensors, [32] and actuators.…”

Section: Introductionmentioning

confidence: 99%

“…[ 10 ] Cellulose fibrils can be treated chemically and mechanically to produce nanofibrillated cellulose (NFC) that consists of nano‐sized fibrils with diameters of less than 20 nm and varying lengths up to several micrometers. There are several examples in the literature where cellulose is combined with synthetic materials [ 11,12 ] such as inorganic nanoparticles, [ 13 ] ionic liquids, [ 14 ] carbon nanotubes, [ 15 ] and conducting polymers [ 16 ] for applications in non‐traditional areas such as energy [ 17 ] and biomedical devices, [ 18 ] water treatment, [ 19 ] optical metamaterials, [ 20,21 ] and smart textiles. [ 22,23 ]…”

Section: Introductionmentioning

confidence: 99%

Elucidating the Bulk Morphology of Cellulose‐Based Conducting Aerogels with X‐Ray Microtomography

Oikonomou,

Dreier,

Sandéhn

et al. 2023

Adv Materials Technologies

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Conducting cellulose composites are promising sustainable functional materials that have found application in energy devices, sensing and water purification. Herein, conducting aerogels are fabricated based on nanofibrillated cellulose and poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate, using the ice templating technique, and their bulk morphology is characterized with X‐ray microtomography. The freezing method (−20 °C in a freezer vs liquid nitrogen) does not impact the mean porosity of the aerogels but the liquid‐N2 aerogels have smaller pores. The integration of carbon fibers as addressing electrodes prior to freezing results in increased mean porosity and pore size in the liquid‐N2 aerogels signifying that the carbon fibers alter the morphology of the aerogels when the freezing is fast. Spatially resolved porosity and pore size distributions also reveal that the liquid‐N2 aerogels are more inhomogeneous. Independent of the freezing method, the aerogels have similar electrochemical properties. For aerogels without carbon fibers, freezer‐aerogels have higher compression modulus and are less stable under cycling compression fatigue test. This can be explained by higher porosity with larger pores in the center of liquid‐N2 aerogels and thinner pore walls. This work demonstrates that micro‐CT is a powerful tool for characterizing the morphology of aerogels in a non‐destructive and spatially resolved manner.

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Nanocellulose composite wound dressings for real-time pH wound monitoring

Cited by 38 publications

References 63 publications

Functional hydrogel dressings for wound management: a comprehensive review

Functional hydrogel dressings for wound management: a comprehensive review

Fluorinated Peptide Nanoscale Hydrogel Accelerates Wound Healing via pH and Oxygen Microenvironment Regulation

Elucidating the Bulk Morphology of Cellulose‐Based Conducting Aerogels with X‐Ray Microtomography

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