Nanocellulose: From an agricultural waste to a valuable pharmaceutical ingredient

Kamel, Rabab; El-Wakil, Nahla A.; Dufresne, Alain; Elkasabgy, Nermeen A.

doi:10.1016/j.ijbiomac.2020.07.242

Cited by 111 publications

(60 citation statements)

References 121 publications

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“…In order to improve the filler–matrix interaction, antibacterial and water contact properties, cellulose surface has been modified by coupling agents through silane‐based treatments, esterification, functionalization, or grafting methods. [ 224 ] Table 2 describes some polymer composites with cellulose extracted from wastes that were incorporated as filler.…”

Section: Agriculture Wastesmentioning

confidence: 99%

Eco‐friendly polymer composites: A review of suitable methods for waste management

Cabrera

2021

Polymer Composites

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The amount of residues generated by agriculture, industrial, or urban activities continuously increases and, consequently, demands several methods for their correct management. The incorrect disposal can cause, in specific cases, environmental contamination by heavy metals or leaching as well as promote the spread of diseases as insect proliferation. Commonly, landfilling, incinerating, composting, or energy/fuel generation can control the disposal or reuse of residues. Among the methods for the reuse of wastes, the incorporation of residues as fillers in polymer composites has emerged as a distinct field. Some composites can potentially mitigate leaching compounds or improve mechanical, thermal, and acoustic properties. However, these improvements are a challenge to promote the use of waste fillers. Thus, this study aims to provide a state of view regarding a variety of wastes used as fillers in polymer composites and different methods to reach mechanical reinforcement as well as improve thermal conductivity and acoustic attenuation for future researches.

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Section: Agriculture Wastesmentioning

confidence: 99%

Eco‐friendly polymer composites: A review of suitable methods for waste management

Cabrera

2021

Polymer Composites

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“…Our approach to stabilizing metastable polymorphs uses cellulose, which is an abundant biopolymer, as an excipient. Cellulose and its derivatives have been used in the pharmaceutical industry for many decades, serving as excipients, fillers, matrices, and drug delivery platforms for a variety of oral dosage forms [40][41][42]. More recently, the nanoscale form, cellulose nanocrystals (CNCs), have been studied as systems for controlled drug release and stabilizing particles [42][43][44].…”

Section: Im Polymorphic Formmentioning

confidence: 99%

“…Cellulose and its derivatives have been used in the pharmaceutical industry for many decades, serving as excipients, fillers, matrices, and drug delivery platforms for a variety of oral dosage forms [40][41][42]. More recently, the nanoscale form, cellulose nanocrystals (CNCs), have been studied as systems for controlled drug release and stabilizing particles [42][43][44]. Nanocellulose aerogels are an exciting new field of light-weight materials that have high surface area and open porosity that can be loaded with active ingredients [45,46].…”

Section: Im Polymorphic Formmentioning

confidence: 99%

Stabilization of Metastable Indomethacin α in Cellulose Nanocrystal Aerogel Scaffolds

Banerjee

Brettmann

2021

Pharmaceutics

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Indomethacin (IM) is a small molecule active pharmaceutical ingredient (API) that exhibits polymorphism with the γ-form being the most thermodynamically stable form of the drug. The α-form is metastable, but it exhibits higher solubility, making it a more attractive form for drug delivery. As with other metastable polymorphs, α-IM undergoes interconversion to the stable form when subjected to certain stimuli, such as solvent, heat, pH, or exposure to seed crystals of the stable form. In this study, IM was crystallized into cellulose nanocrystal aerogel scaffolds as a mixture of the two polymorphic forms, α-IM and γ-IM. Differential scanning calorimetry (DSC) and Raman spectroscopy were used to quantitatively determine the amount of each form. Our investigation found that the metastable α-IM could be stabilized within the aerogel without phase transformation, even in the presence of external stimuli, including heat and γ-IM seed crystals. Because interconversion is often a concern during production of metastable forms of APIs, this approach has important implications in being able to produce and stabilize metastable drug forms. While IM was used as a model drug in this study, this approach could be expanded to additional drugs and provide access to other metastable API forms.

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“…(2) Agro-waste and its impact on environment and its management approaches (Maji et al 2020) (16) Production of nanocellulose from agro-waste for cosmetic formulations (Bongao et al 2020), for pharmaceutical ingredient (Kamel et al 2020).…”

Section: Nano-management Of Agricultural Wastesmentioning

confidence: 99%

“…Several applications of nanotechnology in agricultural sector have been gained a great concern from researchers particularly the nanofertilizers and nano-pesticides as well as its role in the effective management of phytopathogens, controlled release of agrochemicals and nutrient utilization (Pramanik et al 2020). These applications may include some approaches such as using nano-applications in remediation or removal pollutants from the environment (Akhayere et al 2019;Handojo et al 2020), the nano-management of agri-wastes like nano-adsorbent (Kaliannan et al 2019), converting garlic peels into carbon nanomaterials as electrodes for supercapacitors (Bhat et al 2020), nanocellulose as pharmaceutical ingredient (Kamel et al 2020), fabrication of nano-silica (Singh and Endley, 2020), and converting waste-lignin into nano-biochar (Jiang et al 2020). Therefore, this review is an attempt to highlight the agricultural wastes, its classification, applications, management and the common nanomaterials derived from agricultural wastes.…”

Section: Introductionmentioning

confidence: 99%

Agricultural Waste and its Nano-Management: Mini Review

et al. 2020

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A GRICULTURAL wastes are considered residues resulted during the agricultural production and after harvesting fruit and vegetable and their processing, agro-industrial by/co-products from the grapes, banana, olives and milk processing. These wastes may represent a treasure when they are turning into valuable applications (i.e., composts, biochar, adsorbents for removing pollutants from the environment and organic fertilizers) instead of burning it in open fields causing several environmental problems such as soil degradation and air pollution. The landfill disposal and open dumping of agro-wastes is a common practice in the developing countries generating huge amounts of ash, which may create serious health and environmental problems, primarily due to pollution of groundwater. Under the umbrella of the green bioeconomy and based on industrial innovation and high technology, new and better approaches for the recovery of agricultural wastes have been developed. This has contributed to guaranteeing sustainable production and its consumption, resource utilizing efficiency, the conversation of these wastes into valuable products and the reduction of negative environmental impacts.The common management of Agro-wastes may include a lot of suggested uses such as the production of biosynthesis of nanoparticles, biotechnological products, composting and biofuel production. Furthermore, a lot of bioactive compounds could be produced from the agrowastes, which have many application possibilities such as functional food, pharmaceutical and cosmetic approaches. The nano-management of agro-wastes may include using nanotechnology to convert the agro-wastes into a valuable product. This topic still has several open questions, particularly under sustainable and green bioeconomy prespective.

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Nanocellulose: From an agricultural waste to a valuable pharmaceutical ingredient

Cited by 111 publications

References 121 publications

Eco‐friendly polymer composites: A review of suitable methods for waste management

Eco‐friendly polymer composites: A review of suitable methods for waste management

Stabilization of Metastable Indomethacin α in Cellulose Nanocrystal Aerogel Scaffolds

Agricultural Waste and its Nano-Management: Mini Review

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