Nanocellulose mediated injectable bio-nanocomposite hydrogel scaffold-microstructure and rheological properties

Phogat, Kapender; Bandyopadhyay‐Ghosh, Sanchita

doi:10.1007/s10570-018-2001-2

Cited by 36 publications

(47 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is interesting to note that the nanofibrillar structure also shows a 3D network structure, which is anticipated to contribute to the reinforcement efficiency of the nanoentities. Similar network structure and superior reinforcement potential of NC was also reported by previous researchers …”

Section: Resultssupporting

confidence: 88%

“…Besides, use of biodegradable polymeric materials such as PVA successfully eliminates the need for secondary surgery as they decompose inside the body corresponding to the bone regeneration rate . As opposed to pure polymeric hydrogels, composite hydrogel scaffolds can be customized to possess mechanical properties similar to those at the target site of its application, thereby leading to better biological responses, such as reduced stress shielding . An injectable composite system tends to integrate the benefits of a composite system with those of an injectable system .…”

Section: Introductionmentioning

confidence: 99%

“…An injectable composite system tends to integrate the benefits of a composite system with those of an injectable system . Injectable composite hydrogel scaffolds, therefore, are promising materials for tissue engineering, especially for orthopedic applications …”

Section: Introductionmentioning

confidence: 99%

“…The unique approach that has been undertaken in this work stems from natural bone matrix, as it is a heterogeneous natural composite material consisting of polymer matrix phase reinforced with organic nanofibrils. Collagen fibrils within the polymeric extracellular matrix (ECM) in the bone are always in the nanorange . Therefore, nanoenabled composite materials can play an important role to provide an appropriate environment for bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

“…5 As opposed to pure polymeric hydrogels, composite hydrogel scaffolds can be customized to possess mechanical properties similar to those at the target site of its application, thereby leading to better biological responses, such as reduced stress shielding. 5,9,18,[22][23][24][25][26] An injectable composite system tends to integrate the benefits of a composite system with those of an injectable system. 27 Injectable composite hydrogel scaffolds, therefore, are promising materials for tissue engineering, especially for orthopedic applications.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Nano‐enabled poly(vinyl alcohol) based injectable bio‐nanocomposite hydrogel scaffolds

Phogat

Kanwar

Nayak

et al. 2019

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

We report development of poly(vinyl alcohol) (PVA)‐based novel injectable hydrogel nanocomposite scaffolds. Nanocellulose (NC), synthesized from agricultural biomass, was used as reinforcement within PVA matrix. The hydrogels were formed using physical crosslinking process involving multiple freeze–thaw cycles. A range of bio‐nanocomposite hydrogels were prepared with varying concentrations of NC. With increasing loading of NC, crystallinity was found to be increased, which could be attributed to nucleating effect and crystalline nature of nanofibrillar cellulose. Investigation of microstructural surface topology indicated reduced surface perturbations upon incorporation of NC. Fourier transform infrared spectroscopy studies further indicated presence of characteristic functional groups and possible interactions between PVA and NC. Enhanced structural integrity and dynamic stability of the bio‐nanocomposite hydrogels were also confirmed by carrying out rheological investigations at different frequency, amplitude, temperature, and time sweeps. Further, the bio‐nanocomposite hydrogels demonstrated excellent injectability and self‐standing behavior, establishing the promising potential as injectable scaffolds. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48789.

show abstract

Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nano‐enabled poly(vinyl alcohol) based injectable bio‐nanocomposite hydrogel scaffolds

Phogat

Kanwar

Nayak

et al. 2019

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

show abstract

Recent advances on injectable nanocomposite hydrogels towards bone tissue rehabilitation

Phogat

Ghosh

Bandyopadhyay‐Ghosh

2022

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

There has been significant interest in the recent past to develop injectable hydrogel scaffolds that follow minimally invasive implantation procedures towards efficient healing and regeneration of defective bone tissues. Such scaffolds offer several advantages, as they can be injected into the irregularly shaped defect and can act as a low‐density aqueous reservoir, incorporating necessary components for bone tissue repair and augmentation. Considering that bone is a biocomposite of natural biopolymer and bioapatite nanofiller, there has been a growing trend to develop nanocomposite scaffolds by combining biopolymers and inorganic nanofillers to biomimic the hierarchical nanostructure and composition of natural bone. Furthermore, the nanocomposite scaffolds can be tailored to have patient‐specific bone properties, which can lead to better biological responses. The present article begins with the introduction, followed by an overview of polymer matrices, property requirements, and crosslinking techniques employed for injectable hydrogels. Various strategies to develop injectable composites, with emphasis on nanocomposite hydrogels incorporating bioinert and bioactive nanofillers have been discussed. The fundamental challenges related to the development of injectable hydrogel nanocomposite scaffolds and the research efforts directed towards solving these problems have also been reviewed. Finally, future trends and conclusions on new generation injectable hydrogel nanocomposite bone scaffolds have been discussed in this article.

show abstract

Bioactive fluorcanasite reinforced magnesium alloy‐based porous bio‐nanocomposite scaffolds with tunable mechanical properties

et al. 2022

View full text Add to dashboard Cite

Magnesium (Mg) alloy-based porous bio-nanocomposite bone scaffolds were developed by powder metallurgy route. Selective alloying elements such as calcium (Ca), zinc (Zn) and strontium (Sr) were incorporated to tune the mechanical integrity while, bioactive fluorcanasite nano-particulates were introduced within the alloy system to enhance the bone tissue regeneration. Green compacts containing carbamide were fabricated and sintered using two-stage heat treatment process to achieve the targeted porosities. The microstructure of these fabricated magnesium alloy-based bio-nanocomposites was examined by Field emission scanning electron microscope (FE-SEM) and x-ray micro computed tomography (x-ray μCT), which revealed gradient porosities and distribution of alloying elements. X-ray diffraction (XRD) studies confirmed the presence of major crystalline phases in the fabricated samples and the evolution of the various combinations of intermetallic phases of Ca, Mg, Zn and Sr which were anticipated to enhance the mechanical properties. Further, XRD studies revealed the presence of apatite phase for the immersed samples, a conducive environment for bone regeneration. The fabricated samples were evaluated for their mechanical performance against uniaxial compression load. The tunability of compressive strengths and modulus values could be established with variation in porosities of fabricated samples. The retained compressive strength and Young's modulus of the samples following immersion in phosphate buffered saline (PBS) solution was found to be in line with that of natural human cancellous bone, thereby establishing the potential of the fabricated magnesium-alloy-based nanocomposite as a promising scaffold candidate for bone tissue engineering.

show abstract

Nanocellulose mediated injectable bio-nanocomposite hydrogel scaffold-microstructure and rheological properties

Cited by 36 publications

References 18 publications

Nano‐enabled poly(vinyl alcohol) based injectable bio‐nanocomposite hydrogel scaffolds

Nano‐enabled poly(vinyl alcohol) based injectable bio‐nanocomposite hydrogel scaffolds

Recent advances on injectable nanocomposite hydrogels towards bone tissue rehabilitation

Bioactive fluorcanasite reinforced magnesium alloy‐based porous bio‐nanocomposite scaffolds with tunable mechanical properties

Contact Info

Product

Resources

About