Nanochannel-confined platinum nanostructure for enhancement of luminol-dissolved oxygen electrochemiluminescence coupled with gated aptasensor for sensitive detection of carcinoembryonic antigen

An, Jie; Zhang, Chaoyan; Yan, Fei; Ma, Peng

doi:10.1016/j.microc.2024.111413

Microchemical Journal

2024

DOI: 10.1016/j.microc.2024.111413

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Nanochannel-confined platinum nanostructure for enhancement of luminol-dissolved oxygen electrochemiluminescence coupled with gated aptasensor for sensitive detection of carcinoembryonic antigen

Jie An,

Chaoyan Zhang,

Fei Yan

et al.

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Cited by 4 publications

References 56 publications

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Highly specific detection of ROR1 cancer biomarker with bipolar electrochemiluminescence

Mortazavi,

Hosseini,

et al. 2024

Microchim Acta

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Highly specific detection of ROR1 cancer biomarker with bipolar electrochemiluminescence

Mortazavi,

Hosseini,

et al. 2024

Microchim Acta

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Solid-phase electrochemiluminescence immunosensing platform based on bipolar nanochannel array film for sensitive detection of carbohydrate antigen 125

Lu,

Wu,

Luo

et al. 2024

Front. Chem.

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Development of simple solid-phase electrochemiluminescence (ECL) immunosensor with convenient fabrication for high-performance detection of tumor biomarkers is crucial. Herein, a solid-phase ECL immunoassay was constructed based on a bipolar silica nanochannel film (bp-SNA) modified electrode for highly sensitive detection of carbohydrate antigen 125 (CA 125). Inexpensive and readily available indium tin oxide (ITO) electrode was used as the supporting electrode for the growth of bp-SNA. bp-SNA consists of a bilayer SNA film with different functional groups and charge properties, including negatively charged inner layer SNA (n-SNA) and positively charged outer layer SNA (p-SNA). The nanochannels of bp-SNA were used for the immobilization of ECL emitter tris(bipyridine)ruthenium(II), while the outer surface was utilized for constructing the immunorecognition interface. Due to the dual electrostatic interaction composed of electrostatic attraction from n-SNA and electrostatic repulsion from p-SNA, ECL emitter could be stably confined within bp-SNA, providing stable and high ECL signals to the modified electrode. After amino groups on the outer surface of bp-SNA were derivatized with aldehyde groups, recognition antibodies could be covalently immobilized, and an immunosensor was obtained after blocking nonspecific sites. When CA 125 binds to the antibodies on the recognition interface, the formed complex reduces the diffusion of the co-reactant tripropylamine (TPrA) to the supporting electrode, decreasing the ECL signal. Based on this mechanism, the constructed immunosensor can achieve sensitive ECL detection of CA 125. The linear detection range is from 0.01 to 100 U/mL, with a detection limit of 4.7 mU/mL. CA 125 detection in serum is also achieved. The construction immunosensor has advantages including simple and convenient fabrication, high stability of the immobilized emitter, and high selectivity, making it suitable for CA 125 detection.

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Sensitive detection of gallic acid in food by electrochemical sensor fabricated by integrating nanochannel film with nanocarbon nanocomposite

Li,

Lin,

Luo

et al. 2024

Front. Nutr.

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Sensitive detection of gallic acid (GA) in foods is of great significance for assessing the antioxidant properties of products and ensuring consumer health. In this work, a simple electrochemical sensor was conveniently fabricated by integrating vertically-ordered mesoporous silica film (VMSF) with electrochemically reduced graphene oxide (ErGO) and nitrogen graphene quantum dots (NGQDs) nanocomposite, enabling sensitive detection of GA in food sample. A water-soluble mixture of graphene oxide (GO) and NGQDs was drop-cast onto the common carbon electrode, glassy carbon electrode (GCE), followed by rapid growth of VMSF using an electrochemically assisted self-assembly method (EASA). The negative voltage applied during VMSF growth facilitated the in situ reduction of GO to ErGO. The synergistic effects of ErGO, NGQDs, and the nanochannels of VMSF led to nearly a tenfold enhancement of the GA signal compared to that obtained on electrodes modified with either ErGO or NGQDs alone. Sensitive detection of GA was realized with a linear concentration range from 0.1 to 10 μM, and from 10 to 100 μM. The limit of detection (LOD), determined based on a signal-to-noise ratio of three (S/N = 3), was found to be 81 nM. Combined with the size-exclusion property of VMSF, the fabricated sensor demonstrated high selectivity, making it suitable for the sensitive electrochemical detection of gallic acid in food samples.

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Nanochannel-confined platinum nanostructure for enhancement of luminol-dissolved oxygen electrochemiluminescence coupled with gated aptasensor for sensitive detection of carcinoembryonic antigen

Cited by 4 publications

References 56 publications

Highly specific detection of ROR1 cancer biomarker with bipolar electrochemiluminescence

Highly specific detection of ROR1 cancer biomarker with bipolar electrochemiluminescence

Solid-phase electrochemiluminescence immunosensing platform based on bipolar nanochannel array film for sensitive detection of carbohydrate antigen 125

Sensitive detection of gallic acid in food by electrochemical sensor fabricated by integrating nanochannel film with nanocarbon nanocomposite

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