Nanoclay-reinforced electrospun chitosan/PVA nanocomposite nanofibers for biomedical applications

Koosha, Mojtaba; Mirzadeh, Hamid; Shokrgozar, Mohammad Ali; Farokhi, Mehdi

doi:10.1039/c4ra13972k

Cited by 140 publications

(114 citation statements)

References 25 publications

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“…The composite mechanical properties and thermal stability have been shown to increase with chitosan oligosaccharide and montmorillonite contents [58]. XRD results confirmed that these improvements were related to the MMT exfoliation and strong interaction between the PVA/chitosan blend and MMT [58,[60][61][62].…”

Section: Introductionmentioning

confidence: 63%

“…These results revealed that chitosan is miscible in PVA for weight fractions of chitosan w Ch >0.2 [53]. Characterization of films made of chitosan with poly(vinyl alcohol) and montmorillonite has been reported [58][59][60][61][62]. The composite mechanical properties and thermal stability have been shown to increase with chitosan oligosaccharide and montmorillonite contents [58].…”

Section: Introductionmentioning

confidence: 88%

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Characterization of chitosan composites with synthetic polymers and inorganic additives

Lewandowska

2015

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 88%

Characterization of chitosan composites with synthetic polymers and inorganic additives

Lewandowska

2015

International Journal of Biological Macromolecules

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“…According to the reference, it was reported as an endothermic peak derived from chitosan (Koosha et al, 2015). Chitosan peaks at around 60-80 had a tendency to shift slightly as the proportion of oleic acid increases, which is seen as an effect between the chitosan and oleic acid (Ruhi et al, 2015).…”

Section: Dsc Thermograms Of Cbfg-filmsmentioning

confidence: 99%

Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen

Kang

Lee

et al. 2017

Drug Delivery

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The film forming gel, adhered to skin surfaces upon application and formed a film, has an advantage onto skin to provide protection and continuous drug release to the application site. This study aimed to prepare a chitosan-based film forming gel containing ketoprofen (CbFG) and to evaluate the CbFG and film from CbFG (CbFG-film). CbFG were prepared with chitosan, lactic acid and various skin permeation enhancers. The physicochemical characteristics were evaluated by texture analysis, viscometry, SEM, DSC, XRD and FT-IR. To identify the mechanism of skin permeation, in vitro skin permeation study was conducted with a Franz diffusion cell and excised SD-rat and hairless mouse dorsal skin. In vivo efficacy assessment in mono-iodoacetate (MIA)-induced rheumatoid arthritis animal model was also conducted. CbFG was successfully prepared and, after applying CbFG to the excised rat dorsal skin, the CbFG-film was also formed well. The physicochemical characteristics of CbFG and CbFG-film could be explained by the grafting of oleic acid onto chitosan in the absence of catalysts. In addition, CbFG containing oleic acid had a higher skin permeation rate in comparison with any other candidate enhancers. The in vivo efficacy study also confirmed significant anti-inflammatory and analgesic effects. Consequently, we report the successful preparation of chitosan-based film forming gel containing ketoprofen with excellent mechanical properties, skin permeation and anti-inflammatory and analgesic effects. ARTICLE HISTORY

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“…These blends can be converted into variety of forms using different methods like electrospinning, nanofiber drawing, template synthesis, layer-by-layer deposition and self-assembling. Polymer blends and composites is an effective method to achieve new obligations for different properties of the materials [1,2]. Currently, electrospinning of blend polymers are inspected as promising materials for biomedical and industrial applications [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

In-situ crosslinked nanofiber mats of chitosan/poly(vinyl alcohol) blend: Fabrication, characterization and MTT assay with cancerous bone cells

et al. 2015

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Biocompatible crosslinked nanofiber mats of chitosan (CS)/poly(vinyl alcohol) (PVA) were fabricated using electrospinning technique. CS and PVA blends (7, 9 and 11 weight %) of prepared keeping ratios of CS: PVA to 1:4 and was crosslinked with tetraethoxysilane (TEOS). Fourier transform infrared (FTIR) analysis confirmed the existence of inter-and intramolecular hydrogen bonding between polymer chains and the development of siloxane linkage within the nanofibers. Xray diffractometry (XRD) analysis showed an increase in the crystallinity of electrospun nanofibers after crosslinking as compared to the uncrosslinked nanofibers and with an increase in CS/PVA content. Scanning electron microscopy (SEM) micrographs exhibited the formation bead-free fibers at higher polymer concentration. The average size of the nanofibers was found in the range of 40 to 100 nm. The concentration and crosslinker content affected the mechanical and thermal properties of the nanofibers. The crosslinker has increased the tensile strength (TS) values upto 120 % and Young's modulus by 71 % as compared to the uncrosslinked nanofibers while elongation at break was decreased in all nanofibers. The cell viability of the nanofibers was investigated by employing human cancerous bone cells (MG63). The obtained results showed that cancerous bone cells were not proliferated in the presence of nanofibers and the growth of the cells was inhibited confirming the worth of CS/PVA nanofibers against cancerous bone cells. This inherent behaviour can be exploited as base material for anticancer biomedical applications.

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Nanoclay-reinforced electrospun chitosan/PVA nanocomposite nanofibers for biomedical applications

Abstract: Chitosan/PVA/nanoclay nanocomposite nanofibers have been prepared successfully by electrospinning. Bead-free morphology was achieved for the nanofibrous mats and the nanoclays were incorporated and distributed uniformly inside the nanofibers.

Cited by 140 publications

References 25 publications

Characterization of chitosan composites with synthetic polymers and inorganic additives

Characterization of chitosan composites with synthetic polymers and inorganic additives

Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen

In-situ crosslinked nanofiber mats of chitosan/poly(vinyl alcohol) blend: Fabrication, characterization and MTT assay with cancerous bone cells

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