Nanoclays for wound management applications

Mascarenhas-Melo, Filipa; Peixoto, Diana; Aleixo, Carolina; Gonçalves, Maria Beatriz S.; Raza, Faisal; Pawar, Kiran D.; Veiga, Francisco; Paiva‐Santos, Ana Cláudia

doi:10.1007/s13346-022-01279-3

Cited by 12 publications

(3 citation statements)

References 71 publications

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“…They may dissolve in blood instead of stopping arterial and venous bleeding . Besides, the weak adhesive properties of powders prevent them from adhering securely to the wound, impeding the healing process. , Apart from powder-based dressings, hydrogels are well recognized, but they also suffer many limitations including poor portability, low mechanical strength that compromises wound protection, insufficient adherence to the wound surface, and the risk of detachment and secondary wound damage. , Therefore, developing novel wound dressing materials that exhibit excellent biocompatibility and portability, smooth adaptability to various wound shapes, strong adhesion, high mechanical strength, − rapid hemostasis, and anti-inflammatory properties is highly desired. − …”

Section: Introductionmentioning

confidence: 99%

Robust and Wet Adhesive Self-Gelling Powders for Rapid Hemostasis and Efficient Wound Healing

Zhao,

Sun,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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Healing traumatic wounds is arduous, leaving miscellaneous demands for ideal wound dressings, such as rapid hemostasis, superior wet tissue adhesion, strong mechanical properties, and excellent antibacterial activity. Herein, we report a self-gelling, wet adhesive, stretchable (polyethylenimine/poly-(dimethylammonium chloride)/(poly(acrylic acid)/poly(sodium styrenesulfonate)/alkylated chitosan)) ((PEI/PDDA)/(PAA/ PSS)/ACS) powder as a new option. The self-gel utilizes noncovalent interactions among in situ formed PDDA/PSS nanoparticles and PEI/PAA polymetric matrices to earn sensational mechanical properties and tensile strength while incorporating ACS to obtain fast hemostasis and therapeutic capacities. The powder can form a hydrogel patch in situ within 3 s upon liquid absorption, capable of resisting pressure higher than twice the blood pressure. Deposition of the self-gelling powders on various wounds, such as rat liver and femoral artery wounds, can stop bleeding in 10 s and lessen the amount of bleeding 6-fold plus in corresponding models. Furthermore, the self-gelling powders can significantly advance the chronic wound healing process by displaying a high wound healing rate and a low inflammatory response and promoting the formation of new blood vessels and tissue regeneration. The satisfactory mechanical properties, strong wet adhesion, sufficient antibacterial properties, ease of usage, adaptability to complex wounds, rapid hemostasis, and superior therapeutic capacities of (PEI/PDDA)/(PAA/PSS)/ACS self-gelling powders render them as a profound wound dressing biomaterial.

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Section: Introductionmentioning

confidence: 99%

Robust and Wet Adhesive Self-Gelling Powders for Rapid Hemostasis and Efficient Wound Healing

Zhao,

Sun,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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“…1 High levels of disruption and injuries of this essential barrier lead to chronic wounds and failure to heal by unremitting tissue insults under malignancies and diabetes, which can endanger the lives of people as well as incur high treatment costs if wound management is delayed. 2 Therefore, the disruption of skin barrier through wounds needs a selective wound management attempt through an adequate dressing at the earliest possible time to repair the damages. 3 Wound healing involves several complications like sepsis, tissue and skin layer disruption, maggot formation and extension of infection to adjacent and interior organs in major cases.…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing

Akter,

Islam,

Akter

et al. 2024

J Biomater Appl

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Multifunctional and biodegradable dressings with high mechanical strength and good antibacterial activity are crucial in fundamental health services. This study was initiated to prepare a novel curative wound dressing film consisting of natural biodegradable gelatin (G) and polylactic acid (PLA) with silver nanoparticles (AgNPs) where glutaraldehyde (GA) was used as compatibilizer. The prepared composite films addressed the poor thermal and biological stability of G and the limited fluid retention capacity of PLA. Silver nanoparticles were prepared by basic chemical reduction and reinforced on polymer films using simple solvent casting, which obviated common clinical infections and accelerated wound closure rate ( p < .05). Fourier transform infrared (FTIR) studies confirmed composite formation through H-bonding and X-ray diffraction (XRD) revealed increased crystallinity due to incorporating AgNPs. Films with G, PLA & GA (50:50:5 by volume) introduced the best elasticity & strength with excellent fluid retention properties ( p < .05). Scanning electron microscopy (SEM) images unfolded surface morphology and presence of agglomerated AgNPs on film surfaces. Prepared films exhibited significant antimicrobial efficacy against Staphylococcus aureus and Pseudomonas sp. and showed excellent cell viability (>97 %) in Vero cell line. Finally, an in vivo mouse model study showed 99.7 % contraction ( p < .05) within 12 days, which was most effectual and 12 % faster than conventional gauge bandages. These results demonstrated the promising and cost-effective potential of the prepared film for wound healing.

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“…33,34 Therefore, CMs are considered as promising alternatives to synthetic materials in the field of hemostatic materials. 35,36 Historically, CMs were first used in the military field, owing to their excellent procoagulant activity and other unique features, such as lack of allergens derived from human or animals, stable physical and chemical properties, and easy production and transportation. 13,37 A series of simple CM-based hemostatic products have been approved by the Food and Drug Administration for battlefield first aid in recent decades.…”

Section: Introductionmentioning

confidence: 99%

Progress and future prospects of hemostatic materials based on nanostructured clay minerals

Yang,

Wang,

Yang

et al. 2023

Biomater. Sci.

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Nanoclays for wound management applications

Cited by 12 publications

References 71 publications

Robust and Wet Adhesive Self-Gelling Powders for Rapid Hemostasis and Efficient Wound Healing

Robust and Wet Adhesive Self-Gelling Powders for Rapid Hemostasis and Efficient Wound Healing

Silver nanoparticle reinforced polylactic acid and gelatin composite films for advanced wound dressing

Progress and future prospects of hemostatic materials based on nanostructured clay minerals

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