Nanoclusters of crystallographically aligned nanoparticles for magnetic thermotherapy: aqueous ferrofluid, agarose phantoms and<i>ex vivo</i>melanoma tumour assessment

Coral, Diego Fernando; Soto, Paula Andrea Botero; Blank, Viviana C.; Veiga, A.; Spinelli, Enrique Mario; González, Sergio; Saracco, Gustavo P.; Bab, M. A.; Muraca, Diego; Setton-Avruj, Patrícia; Roig, Anna; Roguin, Leonor P.; Raap, M. B. Fernández van

doi:10.1039/c8nr07453d

Cited by 35 publications

(31 citation statements)

References 59 publications

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“…Studies have shown that the temperature above 43 °C could induce cancer cell apoptosis, while the temperature exceeding 45 °C could generate hyperthermia to induce tumor ablation. [ 31 ] As expected, only a maximum temperature of 2 °C was increased in the tumor sites treated with blank MNs ( Figure ), which showed neglectable curative effect in inhibiting tumor growth. Encouragingly, the temperature of the tumor sites treated with PTNPs (PTX/ICG) or PTNPs (ICG) loaded MNs increased quickly to 48 °C within 1 min and kept stable in the next 4 min, which confirmed the good photothermal conversion efficiency of ICG loaded MNs and showed the potential of damaging cancer cells in vivo.…”

Section: Resultssupporting

confidence: 58%

Dissolving Microneedles Loading TPGS Biphasic Functionalized PLGA Nanoparticles for Efficient Chemo‐Photothermal Combined Therapy of Melanoma

Peng

Huang

Feng

et al. 2020

Advanced Therapeutics

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The poly (lactic‐co‐glycolic acid) nanoparticle (PLGA NP) has been widely used in the biomedical field. However, it is insensitive to degradation upon laser irradiation, resulting in a limited increase in drug release, which compromises the therapeutic efficacy. To actively promote drug release, the biphasic α‐tocopheryl succinate (TPGS) functionalized PLGA NPs (PTNPs) are developed by introducing TPGS into the aqueous and organic phase to generate pores in the PLGA core during preparation. Paclitaxel and indocyanine green are encapsulated in the PTNPs to realize chemo‐photothermal combined therapy, and PTNPs are delivered through dissolving microneedles (DMNs) for local treatment in melanoma. PTNPs show enhanced drug release and improved cytotoxicity due to their greater ability in inhibiting cell microtubule depolymerization. In vivo tumor suppression investigation and ki‐67 immunohistochemical staining of tumor tissue further show the superiority of PTNPs loaded DMNs against tumor growth, and photothermal therapy synergistically enhances the chemotherapeutic effect of PTNPs. Moreover, the living imaging of mice demonstrates that the drug is successfully retained in the tumor tissue to avoid it entering into the circulation and producing adverse effects. Therefore, the PTNPs loaded DMNs show a favorable prospect in the treatment of superficial tumor.

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Section: Resultssupporting

confidence: 58%

Dissolving Microneedles Loading TPGS Biphasic Functionalized PLGA Nanoparticles for Efficient Chemo‐Photothermal Combined Therapy of Melanoma

Peng

Huang

Feng

et al. 2020

Advanced Therapeutics

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“…1 Specifically, SPIONs are used as longitudinal 2,3 and transverse magnetic resonance imaging (MRI) contrast agents, 4 in cell labeling, 5 cell sorting 6 or cell therapy, 7 as drug delivery carriers 8 and in thermotherapy for oncological treatments. 9,10 The efficiency of iron oxide nanoparticles for the intended application as well as the particles fate will largely depend on how the nanoparticle surface interacts with the proteins present in a given physiological environment. In a bio-relevant milieu, the formation and time evolution of the protein corona resulting from the biomolecules adsorption on the nanoparticles surface can be extremely diverse and dynamic over time.…”

Section: Introductionmentioning

confidence: 99%

Insights into Preformed Human Serum Albumin Corona on Iron Oxide Nanoparticles: Structure, Effect of Particle Size, Impact on MRI Efficiency, and Metabolization

Moya

Escudero

Malaspina

et al. 2019

ACS Appl. Bio Mater.

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In the last decade there has been profuse research efforts exploring the uses of iron oxide particles in nanomedicine. To a great extent, the efficiency of magnetic iron oxide nanoparticles for biomedical applications and the nanoparticles fate depend on how the nanoparticle surface interfaces with the proteins in a physiological environment. It is well reported how ungoverned protein corona can be detrimental for cellular uptake and targeting efficiency and how it can modify the nanoparticles biodistribution. Novel strategies are emerging to achieve enhanced and more reproducible performances of engineered nanoparticles with a custom-built protein corona. Here we report on a generalized protocol to preform a monolayer of human serum albumin (HSA) on superparamagnetic iron oxide nanoparticles (SPIONs) of different sizes. The resulting molecular structure is described by molecular dynamics simulations of the hybrid nanoconjugates. The number of proteins forming the corona and their disposition as a monolayer on the particle surface predicted by molecular simulations is in agreement with the results obtained from dynamic light scattering and electronic microscopy analysis. Moreover, by tryptophan fluorescence quenching, we determine a strong interaction between the SPIONs and the HSA endorsing the robustness of the proteinnanoparticles conjugates in this system. Besides, the effect of the HSA corona on the SPIONs efficiency as magnetic resonance imaging (MRI) contrast agents in water, human serum and in saline medium has been evaluated. The protein corona did not affect the efficiency of the SPIONs as T 2 contrast agents but reduce their efficiency as T 1. In addition, we observed a greater stability for HSA-SPIONs nanoconjugates in saline and in acid media preventing nanoparticle dissolution in extreme gastric conditions.

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“…Hyperthermia‐Based Therapy : The heat generation by ferromagnetic particles is based on two steps, namely, relaxation and hysteresis loss . When an alternating magnetic field is applied, the magnetic moment changes its original orientation and rubs against the crystal lattice (internal friction, Neel relaxation).…”

Section: Ferrofluid‐based Detection Diagnosis and Therapymentioning

confidence: 99%

Flexible Ferrofluids: Design and Applications

et al. 2019

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Ferrofluids, also known as ferromagnetic particle suspensions, are materials with an excellent magnetic response, which have attracted increasing interest in both industrial production and scientific research areas. Because of their outstanding features, such as rapid magnetic reaction, flexible flowability, as well as tunable optical and thermal properties, ferrofluids have found applications in various fields, including material science, physics, chemistry, biology, medicine, and engineering. Here, a comprehensive, in‐depth insight into the diverse applications of ferrofluids from material fabrication, droplet manipulation, and biomedicine to energy and machinery is provided. Design of ferrofluid‐related devices, recent developments, as well as present challenges and future prospects are also outlined.

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Nanoclusters of crystallographically aligned nanoparticles for magnetic thermotherapy: aqueous ferrofluid, agarose phantoms andex vivomelanoma tumour assessment

Abstract: An integrated approach to advance in the translation of magnetic hyperthermia to clinical uses is described.

Cited by 35 publications

References 59 publications

Dissolving Microneedles Loading TPGS Biphasic Functionalized PLGA Nanoparticles for Efficient Chemo‐Photothermal Combined Therapy of Melanoma

Dissolving Microneedles Loading TPGS Biphasic Functionalized PLGA Nanoparticles for Efficient Chemo‐Photothermal Combined Therapy of Melanoma

Insights into Preformed Human Serum Albumin Corona on Iron Oxide Nanoparticles: Structure, Effect of Particle Size, Impact on MRI Efficiency, and Metabolization

Flexible Ferrofluids: Design and Applications

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