Nanoclusterzyme for Dual Colorimetric Sensings: A Case Study on [Au₁₄(Dppp)₅I₄]²⁺ (Small 30/2023)

Abstract

Nanoclusterzymes In article numbered 2207936, Man‐Bo Li, Yan Zhao, Zhikun Wu, and co‐workers synthesize a novel atomically precise Au14 nanoclusterzyme, which can activate O2 to O2•− under visible light and leads to the blue color of 3,3′,5,5′‐tetramethylbenzidine (TMB). With the addition of acetylcholinesterase (AChE), the blue color of (Au14 + TMB) solution disappears, but the further addition of organophosphorus pesticides (OPs) can recover the blue color. Based on this color on‐off, a nanoclusterzyme‐based dual colorimetric sensing is introduced.

Atomic Precise Gold Nanoclusters: Toward the Customize Synthesis, Precision Medicine

“…Based on the "on-off" and "off-on" modes, colorimetric detection of AChE and OPs can be realized, and the detection limits were 0.04 mU mL −1 and 0.02 ng mL −1 , respectively (Figure 15c,d). [121] Based on the enzyme-like activity of Au clusters, a variety of visual sensing strategies for biomolecules can be established in vitro and in vivo. Using the specific recognition and enzyme-like catalytic properties of atomic precision Au 20 P 5 clusters, Gao et al developed an enzyme-linked immunosorbent assay (ELISA) technique based on novel clusterzyme to effectively amplify the signals of target objects through catalytic reactions.…”

“…AChE could inhibit the activity of Au 14 , while OPs could prevent the inhibition process, to realize the detection process of target object with signal off and on. Reproduced with permission [121]. Copyright 2023, John Wiley and Sons Ltd.…”

Bottom-Up Construction of Metal–Organic Framework Loricae on Metal Nanoclusters with Consecutive Single Nonmetal Atom Tuning for Tailored Catalysis

“…Metal nanoclusters (NCs, ultrasmall metal nanoparticles) have attracted increasing interest in recent years partly due to their tunability with atomic precision. − Metal atom doping has been widely employed for tailoring the physicochemical properties of metal NCs and enabling the composition (structure)–property correlation. − However, surface nonmetal atom introduction, especially “surgery”-like single nonmetal atom doping, replacement, or addition, is challenging owing to the control difficulties. − To the best of our knowledge, surface single nonmetal atom replacement, not to mention successive surface single nonmetal atom doping, replacement, and addition, has not been previously reported. Unlike thiols and phosphines, single nonmetal atoms such as sulfur and halogen can provide more room for access by the substrates and thus facilitate catalytic reactions; − nevertheless, single nonmetal atoms might not protect NCs from attack as well as thiols or phosphines. To counteract the negative effect of surface single nonmetal atom occupation on NC stability, one strategy is to construct loricae for enhanced protection of the metal NCs.…”

Photoluminescence Quenching of Hydrophobic Ag29 Nanoclusters Caused by Molecular Decoupling during Aqueous Phase Transfer and EmissionRecovery through Supramolecular Recoupling

“…[48] In this context, the development of an amphiphilic nanocluster system with manipulable structures and maintainable emissions in the oil/aqueous phase is conducive to promoting the downstream applications of fluorescent clusters. [49][50][51][52][53][54] Such a nanocluster system is helpful for comprehensively studying the aforementioned fluorescence weake ning/quenching mechanism and can facilitate the PL manipulation of hydrophobic nanoclusters in the aqueous phase at the atomic level.…”