2013
DOI: 10.1021/mp300722f
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Nanocolloidal Carriers of Isotretinoin: Antimicrobial Activity against Propionibacterium acnes and Dermatokinetic Modeling

Abstract: Acne, a common skin disease in teenagers, is caused by Propionibacterium acnes (P. acnes). Isotretinoin (ITR) is though reported to have immense antiacne potential, yet there are hardly any reports vouching its antimicrobial activity. The present study, therefore, was undertaken to study the antimicrobial activity of ITR and evaluate the effect of its encasement in nanocarriers on its minimum inhibitory concentration (MIC). The nanocarriers were also evaluated for the skin transport characteristics. MICs of pu… Show more

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Cited by 79 publications
(46 citation statements)
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“…4, the CNTs dispersed in polysorbate 80 show relatively less adsorption on to the surface of E. coli vis-à-vis the CNTs dispersed in unsaturated phospholipid. These findings support the results obtained in the antibacterial studies indicating the enhanced bacterial adsorption by virtue of unsaturated phospholipids (35). The results are unique in nature and provide the first instance of the bacterium cell completely surrounded by MWCNTs when dispersed with the aid of biocomponents like unsaturated phospholipids.…”
Section: Morphology Of the Dispersed Mwcntssupporting
confidence: 90%
See 1 more Smart Citation
“…4, the CNTs dispersed in polysorbate 80 show relatively less adsorption on to the surface of E. coli vis-à-vis the CNTs dispersed in unsaturated phospholipid. These findings support the results obtained in the antibacterial studies indicating the enhanced bacterial adsorption by virtue of unsaturated phospholipids (35). The results are unique in nature and provide the first instance of the bacterium cell completely surrounded by MWCNTs when dispersed with the aid of biocomponents like unsaturated phospholipids.…”
Section: Morphology Of the Dispersed Mwcntssupporting
confidence: 90%
“…However, the blank surfactants and phospholipids did not induce any noticeable antimicrobial activity in the studied concentrations. The findings are in consonance with the earlier reports of enhancement of antimicrobial efficacy with the systems employing unsaturated phospholipids but for other colloidal carriers (34,35). These biomembrane components, i.e., unsaturated phospholipids, facilitate the adherence of the nanosystems with the bacterial cell walls, resulting in the enhancement of the contact time and ultimately the bactericidal action (23).…”
Section: Antibacterial Studiessupporting
confidence: 89%
“…Tween 80 is a well-established non-ionic surfactant for its biocompatibility and better emulsification characteristics (17). In addition to this, there are various studies which report that Tween 80 when incorporated in microemulsion enhances the skin permeation of drugs (36,38).…”
Section: Resultsmentioning
confidence: 99%
“…WinNonlin Ver 5.0 software was employed to compute the various dermatokinetic parameters viz. K p , C Skin max , K e , T Skin max (time required to achieve C Skin max and area under the curve (AUC 0-12 h ) using the Wagner-Nelson method (32,38).…”
Section: Dermatokinetic Modelingmentioning
confidence: 99%
“…The skin tissue was prepared as discussed in BEx Vivo Permeation and Retention Studies^section. At the respective sampling intervals, the whole skin was washed to wipe off the remaining formulation and further soaked in hot water (60°C) for 30 s to separate the epidermis from the dermis (31,32). The sections were cut in small pieces and macerated in ethanol (5 mL) for 24 h. The filtrate was filtered and analysed using the RP-HPLC technique.…”
Section: Dermatokinetic Modellingmentioning
confidence: 99%