Nanocomposite clay-polymer microbeads for oral controlled drug delivery: Development and, in vitro and in vivo evaluations

Raut, Sushil; Gahane, Avinash; Joshi, Manjunath B.; Kalthur, Guruprasad; Mutalik, Srinivas

doi:10.1016/j.jddst.2019.03.001

Cited by 26 publications

(18 citation statements)

References 15 publications

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“…In this scenario, clay hydrogel beads have been widely investigated in oral drug delivery applications, showing that mineral clays can be successfully used as functional additives in the development of bead-modified systems [20].…”

Section: Introductionmentioning

confidence: 99%

Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release

et al. 2019

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In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare polymeric beads. Rheological studies and preliminary experiments of beads preparation allowed to identify the GG and the CaCl2 concentrations suitable for obtaining stable and spherical particles. GG beads were formed, through ionotropic gelation technique, with and without the presence of the synthetic clay laponite. The resultant beads were analyzed for dimensions (before and after freeze-drying), morphological aspects and ability to swell in different media miming biological fluids, namely SGF (Simulated Gastric Fluid, HCl 0.1 M) and SIF (Simulated Intestinal Fluid, phosphate buffer, 0.044 M, pH 7.4). The swelling degree was lower in SGF than in SIF and further reduced in the presence of laponite. The GG and GG-layered silicate composite beads were loaded with two model drugs having different molecular weight, namely theophylline and cyanocobalamin (vitamin B12) and subjected to in-vitro release studies in SGF and SIF. The presence of laponite in the bead formulation increased the drug entrapment efficiency and slowed-down the release kinetics of both drugs in the gastric environment. A moving-boundary swelling model with “diffuse” glassy-rubbery interface was proposed in order to describe the swelling behavior of porous freeze-dried beads. Consistently with the swelling model adopted, two moving-boundary drug release models were developed to interpret release data from highly porous beads of different drugs: drug molecules, e.g., theophylline, that exhibit a typical Fickian behavior of release curves and drugs, such as vitamin B12, whose release curves are affected by the physical/chemical interaction of the drug with the polymer/clay complex. Theoretical results support the experimental observations, thus confirming that laponite may be an effective additive for fabricating sustained drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release

et al. 2019

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“…Despite the growing interest in using these materials, as can be seen by the increase in the number of articles and patents filed each year, articles with chitosan and a laponite associated with seed coating on the same base were not found. However, these materials can be used in the coating of foods such as fruits (Wu et al, 2018), manufacture of biosensors (Shan et al, 2010), as biosensors for detection of phenols (Fan et al, 2007) and L-Lactate, which is an important food freshness and flavor standard (Zanini et al, 2011), in the adsorption of metals and dyes (Xu et al, 2019) and proteins (Mahdavinia et al, 2018).Most of these materials were combined for use in the medical field, an example of bioadhesive feeding and controlled drug administration (Gharaie et al, 2018;Chen et al, 2019;Raut et al, 2019;Nikfarjam and Kokabi, 2020;Rebitski et al, 2020), in the treatment of bleeding (Gaharwar et al, 2014) and wound treatment (Kiaee et al, 2018), improve cell adhesion and biomineralization (Gaharwar et al, 2010;Cebe et al, 2020), osteoinducers in bone tissue engineering (Zhang et al, 2020;Arab-Ahmadi et al, 2021). See the antifungal and antibacterial activities of chitosan and laponite these materials have been reported to regenerate skin and are promising determinants as curatives (Gonzaga et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Chitosan and Laponite: a meta-analysis on their applications

Lima

Silva-Mann

Sarmento

2021

RSD

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Chitosan is a renewable natural alkaline polysaccharide, and laponite is a multifunctional nanocomposite. Their use exists in several areas, mainly due to their non-toxicity and because chitosan is from natural resources. One primary use in seed coating processes consists of applying an exogenous material to the seeds, which can facilitate handling and planting. Thus, this study aimed to investigate the most appropriate uses in patented and publications related to the use of Laponite and Chitosan to access these materials' state of the art to identify perspectives for new research. One hundred two publications were explored in the scientific databases Scopus (53) and Web of Science (WoS) (79). Of these, duplicates were removed, totaling 93 articles with publications started in 2006. The number of publications on chitosan and laponite for the countries with the highest number of corresponding authors was from China (27), Iran (16), and the United States (15). Brazil also stands out and occupies the fourth position regarding the number of corresponding authors (7). There were prospected 109 patents, and most of them have been used in medical or veterinary hygiene, or hygienic devices and methods (A61K), in cosmetics (A61Q). The compilation and analysis of scientific, technological, and information use carried out in this work has allowed for identifying the new research perspectives and validated the potential use of chitosan and laponite association as a seed coating.

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“…Figure denotes the microbead structure and the mechanism of drug release for this system. Further, this CPNH microbeads display longer anti‐inflammatory effect in rats compared to pure drug, revealing its suitability even at higher doses without exhibiting any signs of gastric mucosal damage (Raut et al, ). The potential of LAP in composing CPNH as a dual drug delivery vehicle encapsulating both methotrexate (MTX) and ciprofloxacin (CIF) for tumor therapy has been studied.…”

Section: Different Types Of Oinhsmentioning

confidence: 99%

“…Microbead structure of sodium diclofenac (SD)–montmorillonite (MMT)–sodium alginate (SA) and mechanism of drug release. (Reprinted with permission from Raut, Gahane, Joshi, Kalthur, and Mutalik (). Copyright 2019 Elsevier Ltd)…”

Section: Different Types Of Oinhsmentioning

confidence: 99%

Recent developments in the use of organic–inorganic nanohybrids for drug delivery

Manatunga

Godakanda

Silva

et al. 2019

WIREs Nanomed Nanobiotechnol

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Organic–inorganic nanohybrid (OINH) structures providing a versatile platform for drug delivery with improved characteristics are an area which has gained recent attention. Much effort has been taken to develop these structures to provide a viable treatment options for much alarming diseases such as cancer, bone destruction, neurological disorders, and so on. This review focuses on current work carried out in producing different types of hybrid drug carriers identifying their properties, fabrication techniques, and areas where they have been applied. A brief introduction on understating the requirement for blending organic–inorganic components into a nanohybrid drug carrier is followed with an elaboration given about the different types of OINHs developed currently highlighting their properties and applications. Then, different fabrication techniques are discussed given attention to surface functionalization, one‐pot synthesis, wrapping, and electrospinning methods. Finally, it is concluded by briefing the challenges that are remaining to be addressed to obtain multipurpose nanohybrid drug carriers with wider applicability. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Nanocomposite clay-polymer microbeads for oral controlled drug delivery: Development and, in vitro and in vivo evaluations

Cited by 26 publications

References 15 publications

Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release

Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release

Chitosan and Laponite: a meta-analysis on their applications

Recent developments in the use of organic–inorganic nanohybrids for drug delivery

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