Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery

Merino, Sonia; Martín, Cristina; Kostarelos, Kostas; Prato, Maurizio; Vázquez, Éster

doi:10.1021/acsnano.5b01433

Cited by 700 publications

(475 citation statements)

References 76 publications

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“…This capacity for recovery after high shear is particularly relevant for injectable gels sheared through a needle as following injection the gel would be required to revert back to its original state. Although this self-healing property has been extensively reported for polymeric systems, [13][14][15][16][17] there are fewer reports for LMW gels. [9][10][11] Pertinent examples are dipeptide gels (Fmoc-Leucinylglycine and Fmocphenylalaninylphenylalanine) which have been shown to recover after shear in similar experiments.…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 98%

“…Indeed the self-healing properties of LMWGs is uncommon 12 when compared to the reported self-healing of polymer hydrogels. [13][14][15][16][17] In the studies reported here we will describe the rare self-healing properties of a nucleoside based gelator. Previously described gelation of acylated nucleoside gelators based on cytidine were carried out in a binary system of ethanol and water, where the ethanol content contributed 40 % to the overall solvent volume.…”

Section: Introductionmentioning

confidence: 99%

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Developing a self-healing supramolecular nucleoside hydrogel

et al. 2016

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2ʹ-deoxycytidine (0.5 % w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging . The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines.

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Section: Please Do Not Adjust Marginsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Developing a self-healing supramolecular nucleoside hydrogel

et al. 2016

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“…in the polymer chains, this series of hydrogels have been employed in a variety of industries, such as agriculture (water-reserving in soil and controlled release of agrochemicals), drug delivery system, separation technology, sludge/coal dewatering and so on [29,30]. Recently, the trend of research has engaged in the integration of functional nanoparticles, such as quantum dot, metal or metal oxide and carbon-based nanocomposites so as to obtain hybrid composite hydrogels with fluorescene, magnetism, dielectric and catalytic properties for a large amount of practical usages [31][32][33]. The conclusion has been drawn that the composites of hydrogels not only overwhelm the disadvantages of hydrogels by combining the advantages of constituents, but also reduce the capital of the industrial polymers.…”

Section: Palygorskite-based Composite Hydrogels For the Adsorption Ofmentioning

confidence: 99%

Advances in Composites Based on the Palygorskite Mineral Nanofibers

Liu¹,

Wang²,

Wu³

2016

Proceedings of the 4th 2016 International Conference on Material Science and Engineering (ICMSE 2016)

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Abstract. Synthetic nanomaterials have the disadvantages of large-scale investment, high energy consumption, complex production process and heavy environmental load. Palygorskite mineral nanofibers are typical porous materials widely existing in nature and have the advantage of high surface area, moderate cation exchange capacity and excellent salt resistance, which have been widely applied as adsorbents in the dyes' removal from waste water. Due to the aggregation of palygorskite crystal bundles, it is difficult to totally release the adsorption capacity of palygorskite. Therefore, it is necessary to modify the microscopic structure of palygorskite with various physical or chemical techniques. Based on the above reason, this paper briefly summarizes the palygorskite-based composites research progress of palygorskite mineral nanofibers, and related research orientations have also been proposed.

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“…Moreover, the combination of inorganic nanoparticles with interesting physical properties can be incorporated into the nanogel network. For example, magnetic particles can be combined into a nanogel matrix forming magnetic nanogels (MNG) [28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration

et al. 2018

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Magnetic nanogels (MNGs) are designed to have all the required features for their use as highly efficient trapping materials in the challenging task of selectively capturing circulating tumor cells (CTCs) from the bloodstream. Advantageously, the discrimination of CTCs from hematological cells, which is a key factor in the capturing process, can be optimized by finely tuning the polymers used to link the targeting moiety to the MNG. We describe herein the relationship between the capturing efficiency of CTCs with overexpressed transferrin receptors and the different strategies on the polymer used as linker to decorate these MNGs with transferrin (Tf). Heterobifunctional polyethylene glycol (PEG) linkers with different molecular weights were coupled to Tf in different ratios. Optimal values over 80% CTC capture efficiency were obtained when 3 PEG linkers with a length of 8 ethylene glycol (EG) units were used, which reveals the important role of the linker in the design of a CTC-sorting system.

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Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery

Cited by 700 publications

References 76 publications

Developing a self-healing supramolecular nucleoside hydrogel

Developing a self-healing supramolecular nucleoside hydrogel

Advances in Composites Based on the Palygorskite Mineral Nanofibers

Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration

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