Nanocomposite multifunctional hydrogel for suppressing osteosarcoma recurrence and enhancing bone regeneration

PgC3Mg metal–organic cages functionalized hydrogels with enhanced bioactive and ROS scavenging capabilities for accelerated bone regeneration

“…Our results indicated that the sustained release of Mg ions from the GelMA/PgC 3 Mg gels could significantly promote in vitro osteogenic differentiation and in vivo bone regeneration. These results were consistent with previous studies based on efficient chelation reactions between bisphosphonate 51 or phosphocreatine 52 or phosphonate 53 decorated polymers and Mg ions, which showed enhanced in vitro osteogenic differentiation, mineralization, and in vivo new bone formation in large bone defects of rats. In our study, motivated by the initial discovery of PgC 3 and subsequent demonstration of their strong coordination capability with Mg ions by Atwood groups, 36,54,55 the introduction of the self-assembly PgC 3 Mg capsules into the GelMA hydrogels shows several advantages as follows: the strong hydrogen bonds based on polyphenols and Mg ions that are surrounded by hydrophobic methyl groups are remarkedly conducive to prolonging the sustained release of Mg ions in the bone defect.…”

Injectable hydrogels in central nervous system: Unique and novel platforms for promoting extracellular matrix remodeling and tissue engineering

“…The ability to adjust the time and position of crosslinking under physiological settings has made photo-crosslinking approaches popular in recent years to generate injectable hydrogels for CNS and other tissues engineering [ [171] , [172] , [173] ]. Considering that some injectable hydrogels have low mechanical strength, the use of photo-responsive hydrogels can overcome the conflict between hydrogel injectability and mechanical strength [ 174 ].…”

Preparation and characterization of photocurable composite extracellular matrix-methacrylated hyaluronic acid bioink

“…8 A commonly used material for bioinks is a hydrogel, which is a hydrated network of crosslinked natural or synthetic polymers. 9,10 The synthetic materials can be tailored with specific physical properties, robust mechanical properties and good control over degradation time after the tissue is fully regenerated. 11 However, poor biocompatibility, non-natural degradation products, and a loss of mechanical properties during degradation are limiting their usages.…”