Nanocomposite of Palladium Nanoparticles Anchored on Boron Nitride Nanosheets as a Sensor for Liver Treatment Drug Silymarin

Shokri, Foroozan; Yari, Abdollah

doi:10.1021/acsaelm.3c01460

ACS Appl. Electron. Mater.

2023

DOI: 10.1021/acsaelm.3c01460

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Nanocomposite of Palladium Nanoparticles Anchored on Boron Nitride Nanosheets as a Sensor for Liver Treatment Drug Silymarin

Foroozan Shokri,

Abdollah Yari

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2024

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Determination of the Major Bioactive Component of Silybum marianum in Nutricosmetics by a HPLC Method With Amperometric Detection and UAE Pretreatment

Abad‐Gil,

Gismera,

Sevilla

et al. 2024

Phytochemical Analysis

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IntroductionNutricosmetics derived from Silybum marianum, known for their anti‐inflammatory and hepatoprotective properties, necessitate accurate quantification of silybin, a key bioactive component.ObjectivesThis study aims to develop a novel high‐performance liquid chromatography (HPLC) method with amperometric detection (HPLC‐ECD) for the precise determination of silybin. An ultrasound‐assisted extraction (UAE) procedure is also established for solid sample preparation prior to chromatographic analysis.Materials and MethodsChromatographic separation of silybin was performed on a C18 column and using methanol–0.035 M potassium phosphate (pH 4.0) at 1.0 mL min−1 flow rate as mobile phase in gradient mode. The electrochemical detection (ECD) of silybin was carried out on a glassy carbon electrode (GCE) at +1.10 V versus Ag/AgCl. The UAE procedure for silybin extraction from solid samples was performed by 15 min sonication in an ultrasonic bath (80 kHz and 100% power) at room temperature.ResultsUnder the optimal chromatographic conditions, silybin diastereoisomers (silybin A and silybin B) can be separated from other S. marianum flavonolignans in less than 20 min, with a detection limit (LOD) of 0.060 mg L−1 and a reproducibility (RSD) of 5%. This method was successfully applied to analyze silymarin‐containing products with recoveries close to 100%.ConclusionsThis work presents the first HPLC method for silybin determination using an amperometric detector with a GCE. The LOD is competitive in comparison with previously published HPLC‐DAD methods. This HPLC‐ECD method allows silybin diastereoisomers identification without interferences of other flavonolignans present in silymarin extracts.

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Determination of the Major Bioactive Component of Silybum marianum in Nutricosmetics by a HPLC Method With Amperometric Detection and UAE Pretreatment

Abad‐Gil,

Gismera,

Sevilla

et al. 2024

Phytochemical Analysis

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Nanocomposite of Palladium Nanoparticles Anchored on Boron Nitride Nanosheets as a Sensor for Liver Treatment Drug Silymarin

Cited by 1 publication

References 52 publications

Determination of the Major Bioactive Component of Silybum marianum in Nutricosmetics by a HPLC Method With Amperometric Detection and UAE Pretreatment

Determination of the Major Bioactive Component of Silybum marianum in Nutricosmetics by a HPLC Method With Amperometric Detection and UAE Pretreatment

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