Nanocomposite of starch, gelatin and itaconic acid-based biodegradable hydrogel and ZnO/cellulose nanofiber: A pH-sensitive sustained drug delivery vehicle

Bora, Ashok; Sarmah, Dimpee; Rather, Muzamil Ahmad; Mandal, Manabendra; Karak, Niranjan

doi:10.1016/j.ijbiomac.2023.128253

Cited by 7 publications

(2 citation statements)

References 62 publications

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“…Hydrogel nanocomposites (HNC) are hybrid materials composed of organic (polymeric nanoparticles, micelles, polymerosomes, dendrimers, and liposomes) and inorganic nanoparticles (inorganic clay nanoparticles, silica, silicates, hydroxyapatite, calcium phosphate, quantum dots) embedded into the hydrogels [13]. Incorporation of the drug into nanoparticles reduces the effect of burst release and enhances the steadiness or stability by providing sustained or controlled release.…”

Section: Introductionmentioning

confidence: 99%

Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis

Mehta,

Velagacherla,

Manandhar

et al. 2024

AAPS PharmSciTech

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Oral submucous fibrosis (OSF) is a chronic progressive disease associated with increased collagen deposition and TGF-β1 release. The current therapy and management have been a limited success due to low efficacy and adverse drug reactions. This study aimed to evaluate epigallocatechin 3-gallate (EGCG) encapsulated nanoparticles loaded mucoadhesive hydrogel nanocomposite (HNC) for OSF. Developed HNC formulations were evaluated for their permeation behaviour using in vitro as well as ex vivo studies, followed by evaluation of efficacy and safety by in vivo studies using areca nut extract-induced OSF in rats. The disease condition in OSF-induced rats was assessed by mouth-opening and biochemical markers. The optimized polymeric nanoparticles exhibited the required particle size (162.93 ± 13.81 nm), positive zeta potential (22.50 ± 2.94 mV) with better mucoadhesive strength (0.40 ± 0.002 N), and faster permeation due to interactions of the positively charged surface with the negatively charged buccal mucosal membrane. HNC significantly improved disease conditions by reducing TGF-β1 and collagen concentration without showing toxicity and reverting the fibroid buccal mucosa to normal. Hence, the optimized formulation can be further tested to develop a clinically alternate therapeutic strategy for OSF. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis

Mehta,

Velagacherla,

Manandhar

et al. 2024

AAPS PharmSciTech

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“…Acrylamide (AAm) is a nonionic hydrophilic monomer and has garnered extensive attention in the development of pH-responsive nanogels or hydrogels. , The homomer of AAm, i.e., poly-AAm (PAAm), is nontoxic and hence finds wide-ranging applications in biomedical applications, food packaging, and water purification. , However, to synthesize smart and mechanically stable nanogels, AAm should be typically copolymerized with another monomer containing a weak acid functionality . Itaconic acid (IAc) stands out as one such monomer widely utilized for various applications, including drug delivery vehicles, bioadhesives, superabsorbent polymers, ion exchange resins, and chelating agents . IAc is naturally derived and hence is biocompatible and nontoxic .…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Kumawat,

Karmakar,

Ghoroi

2024

ACS Appl. Nano Mater.

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In the realm of colon-based drug delivery, developing a pHresponsive nanocarrier that exhibits significant intrinsic reactive oxygen species (ROS) scavenging activity holds great promise. To address this, a nanogel (NG) is synthesized using itaconic acid (IAc) and acrylamide (AAm) monomers in a molar ratio of 1:4 via free radical polymerization. The spherical NG of size 190 ± 15 nm is confirmed by using field emission scanning electron microscopy (FESEM). Dynamic light scattering (DLS) characterization reveals a hydrodynamic diameter and zeta potential of 271 ± 23 nm and −6.9 ± 2.3 mV, respectively. FTIR, XPS, and NMR analyses confirm the presence of multiple functionalities on the NG. Significant improvement in swelling (10 times) at colonic pH (pH 7.4) in contrast to gastric pH (pH 1.2) ensures the pH-responsive behavior of a NG along with five times higher ROS scavenging activity compared to control. As a model drug, doxorubicin (DOX) is employed to investigate release properties and cellular uptake. The NG exhibited drug loading capacity and efficiency of 26 ± 1.2% and 90 ± 1.3%, respectively, with a three times higher DOX release at pH 7.4 than at pH 1.2. Rheology data reveal the superior structural integrity of the doxorubicin loaded nanogel (DNG) compared to the NG. The biocompatibility of the NG is confirmed through MTT, the hemolysis assay, and cell uptake assays on HCT-116 colon cancer cells. The cellular uptake studies have indicated NG-mediated drug release in the colon microenvironment with subsequent passive diffusion of DOX into cells. These findings underscore the capability of the synthesized NG as a vehicle for oral drug delivery to the colon.

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The formation and performance tuning mechanism of starch-based hydrogels

Zhang,

Liu,

Sun

et al. 2025

Carbohydrate Polymers

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Nanocomposite of starch, gelatin and itaconic acid-based biodegradable hydrogel and ZnO/cellulose nanofiber: A pH-sensitive sustained drug delivery vehicle

Cited by 7 publications

References 62 publications

Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis

Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

The formation and performance tuning mechanism of starch-based hydrogels

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