Nanocomposites and Its Applications

Sonawane, Gunvant H.; Patil, Sandip P.; Sonawane, Shirish H.

doi:10.1016/b978-0-08-101971-9.00001-6

Cited by 32 publications

(21 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The interaction also appears to be selective for the cis isomer of CE3F4R. As described previously, 31,62 CE3F4R samples a pre-existing slow exchanging equilibrium caused by cis/trans isomerization of the formyl moiety (denoted with C and T subscripts, respectively). The C6 resonance of the trans isomer only shifts by about 0.02 ppm upon addition of TX, while the C6 resonance of the cis isomer shifts by up to 0.34 ppm.…”

Section: Investigation Of Triton X-100 (Tx) As An Agent To Attenuate mentioning

confidence: 59%

Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators

Boulton¹,

Selvaratnam

Ahmed³

et al. 2019

J. Med. Chem.

View full text Add to dashboard Cite

A common source of false positives in drug discovery is ligand self-association into large colloidal assemblies that nonspecifically inhibit target proteins. However, the mechanisms of aggregationbased inhibition (ABI) and ABI-attenuation by additives, such as Triton X-100 (TX) and human serum albumin (HSA), are not fully understood. Here, we investigate the molecular basis of ABI and ABI-attenuation through the lens of NMR and coupled thermodynamic cycles. We unexpectedly discover a new class of aggregating ligands that exhibit negligible interactions with proteins but act as competitive sinks for the free inhibitor, resulting in bell-shaped dose-response curves. TX attenuates ABI by converting inhibitory, protein-binding aggregates into nonbinding coaggregates, whereas HSA minimizes nonspecific ligand interactions by functioning as a reservoir for free inhibitor and preventing self-association. Hence, both TX and HSA are useful tools to minimize false positives arising from nonspecific binding but at the cost of potentially introducing false negatives due to suppression of specific interactions.

show abstract

Section: Investigation Of Triton X-100 (Tx) As An Agent To Attenuate mentioning

confidence: 59%

Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators

Boulton¹,

Selvaratnam

Ahmed³

et al. 2019

J. Med. Chem.

View full text Add to dashboard Cite

show abstract

“…The hydrothermal method (Figure 2D) refers to the use of aqueous solvents at high temperature and pressure for the synthesis of QDs (Sonawane et al, 2018). The synergetic effect of these conditions leads to the rapid formation of nuclei, resulting in monodisperse QDs that do not require post-synthesis treatments in order to be compatible with aqueous media.…”

Section: Ll Open Accessmentioning

confidence: 99%

NIR-quantum dots in biomedical imaging and their future

et al. 2021

View full text Add to dashboard Cite

Fluorescence imaging has gathered interest over the recent years for its real-time response and high sensitivity. Developing probes for this modality has proven to be a challenge. Quantum dots (QDs) are colloidal nanoparticles that possess unique optical and electronic properties due to quantum confinement effects, whose excellent optical properties make them ideal for fluorescence imaging of biological systems. By selectively controlling the synthetic methodologies it is possible to obtain QDs that emit in the first (650-950 nm) and second (1000-1400 nm) near infra-red (NIR) windows, allowing for superior imaging properties. Despite the excellent optical properties and biocompatibility shown by some NIR QDs, there are still some challenges to overcome to enable there use in clinical applications. In this review, we discuss the latest advances in the application of NIR QDs in preclinical settings, together with the synthetic approaches and material developments that make NIR QDs promising for future biomedical applications.

show abstract

“…As a green, highly efficient and ecological technology, heterogeneous photocatalysis for the treatment of organic pollutants present in wastewater has been shown to be a promising technology to face future environmental challenges [42].…”

Section: Heterogeneous Photocalalytic Processesmentioning

confidence: 99%

Advanced Oxidation Processes Coupled with Nanomaterials for Water Treatment

Cardoso

Silva

2021

Nanomaterials

View full text Add to dashboard Cite

Water quality management will be a priority issue in the near future. Indeed, due to scarcity and/or contamination of the water, regulatory frameworks will be increasingly strict to reduce environmental impacts of wastewater and to allow water to be reused. Moreover, drinking water quality standards must be improved in order to account for the emerging pollutants that are being detected in tap water. These tasks can only be achieved if new improved and sustainable water treatment technologies are developed. Nanomaterials are improving the ongoing research on advanced oxidation processes (AOPs). This work reviews the most important AOPs, namely: persulfate, chlorine and NH2Cl based processes, UV/H2O2, Fenton processes, ozone, and heterogeneous photocatalytic processes. A critical review of the current coupling of nanomaterials to some of these AOPs is presented. Besides the active role of the nanomaterials in the degradation of water contaminants/pollutants in the AOPs, the relevance of their adsorbent/absorbent function in these processes is also discussed.

show abstract

Nanocomposites and Its Applications

Cited by 32 publications

References 64 publications

Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators

Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators

NIR-quantum dots in biomedical imaging and their future

Advanced Oxidation Processes Coupled with Nanomaterials for Water Treatment

Contact Info

Product

Resources

About