Nanocomposites Based on Biodegradable Polymers

Armentano, Ilaria; Puglia, Debora; Luzi, Francesca; Arciola, Carla Renata; Morena, Francesco; Martino, Sabata; Torre, Luigi

doi:10.3390/ma11050795

Cited by 101 publications

(56 citation statements)

References 156 publications

(220 reference statements)

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“…This behaviour refers to with BNC with degradable polymeric matrices like poly(lactic acid) (PLA), poly(butylene adipate- co -terephthalate) and thermoplastic starch which undergo degradation after various time period. Different biodegradation conditions can be considered: hydrolytic, composting, enzymatic, according to the final applications and the post-use of the new developed materials [ 128 ].…”

Section: Polymeric Nanocompositesmentioning

confidence: 99%

Polymeric Nanocomposites and Nanocoatings for Food Packaging: A Review

Vasile

2018

Materials

198

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Special properties of the polymeric nanomaterials (nanoscale size, large surface area to mass ratio and high reactivity individualize them in food packaging materials. They can be processed in precisely engineered materials with multifunctional and bioactive activity. This review offers a general view on polymeric nanocomposites and nanocoatings including classification, preparation methods, properties and short methodology of characterization, applications, selected types of them used in food packaging field and their antimicrobial, antioxidant, biological, biocatalyst and so forth, functions.

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Section: Polymeric Nanocompositesmentioning

confidence: 99%

Polymeric Nanocomposites and Nanocoatings for Food Packaging: A Review

Vasile

2018

Materials

198

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“…In the last years, the use of nanofillers (length < 100 nm) for the production of polymer nanocomposites has received great attention in academic research and industry. Even with low nanofiller content, nanocomposites exhibited unique properties compared to conventional composites [93,94]. The significant higher surface-tovolume ratio of nanoparticles and their extremely higher characteristic ratio increase ductility with no decrease of strength and scratching resistance [95].…”

Section: Materials For Ligament/tendon Scaffoldsmentioning

confidence: 99%

“…Besides, with the incorporation of nanoparticles in the polymer matrix, new properties may arise, which would not be possible when using macrosized particles [93]. Several nanocomposites with biodegradable polymer matrices have been developed specifically for various biomedical purposes such as drug delivery, tissue engineering, wound dressings, stem cell therapy and cancer therapy [94,95]. The specific use of biodegradable polymer matrices for the production of the nanocomposites offers great advantages and include the ability to tailor mechanical properties and degradation kinetics to suit various applications [96].…”

Section: Materials For Ligament/tendon Scaffoldsmentioning

confidence: 99%

Biodegradable polymer nanocomposites for ligament/tendon tissue engineering

et al. 2020

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Ligaments and tendons are fibrous tissues with poor vascularity and limited regeneration capacity. Currently, a ligament/tendon injury often require a surgical procedure using auto-or allografts that present some limitations. These inadequacies combined with the significant economic and health impact have prompted the development of tissue engineering approaches. Several natural and synthetic biodegradable polymers as well as composites, blends and hybrids based on such materials have been used to produce tendon and ligament scaffolds. Given the complex structure of native tissues, the production of fiber-based scaffolds has been the preferred option for tendon/ligament tissue engineering. Electrospinning and several textile methods such as twisting, braiding and knitting have been used to produce these scaffolds. This review focuses on the developments achieved in the preparation of tendon/ ligament scaffolds based on different biodegradable polymers. Several examples are overviewed and their processing methodologies, as well as their biological and mechanical performances, are discussed. Fig. 20 a 3D view of the theoretical designed PLA screw-like scaffold structure. b The prepared PLA screw-like scaffold. c The SEM image of the PLA scaffold surface with well-defined orthogonal structure (Reprinted with permission from [114])

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“…As a matter of fact, the modulation of physical and chemical properties of biomaterials such as architecture, shape, mechanical properties, and surface structure, have been showed to control the biological responses of stem cells (both stemness and differentiation properties) [113,115,116]. Many types of natural or synthetic biomaterials, such as polymers, ceramics, bio-glass, composites, or seldom metals [37,[117][118][119][120][121][122][123], have been combined with different types of stem cells in order to faithfully recapitulate key environmental signals (thus allowing finer cell/tissue models [11,124]) and elucidate complex biological phenomena such as stem cell reprogramming pathways and determination processes [14]. To date, some tissue engineering strategies have already reached the market and are used as personalized therapies.…”

Section: Ex Vivo Stem Cell-based Systems: Bio-hybrid Models For Tissumentioning

confidence: 99%

Harnessing the Potential of Stem Cells for Disease Modeling: Progress and Promises

Argentati

Tortorella

Bazzucchi

et al. 2020

JPM

Self Cite

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Ex vivo cell/tissue-based models are an essential step in the workflow of pathophysiology studies, assay development, disease modeling, drug discovery, and development of personalized therapeutic strategies. For these purposes, both scientific and pharmaceutical research have adopted ex vivo stem cell models because of their better predictive power. As matter of a fact, the advancing in isolation and in vitro expansion protocols for culturing autologous human stem cells, and the standardization of methods for generating patient-derived induced pluripotent stem cells has made feasible to generate and investigate human cellular disease models with even greater speed and efficiency. Furthermore, the potential of stem cells on generating more complex systems, such as scaffold-cell models, organoids, or organ-on-a-chip, allowed to overcome the limitations of the two-dimensional culture systems as well as to better mimic tissues structures and functions. Finally, the advent of genome-editing/gene therapy technologies had a great impact on the generation of more proficient stem cell-disease models and on establishing an effective therapeutic treatment. In this review, we discuss important breakthroughs of stem cell-based models highlighting current directions, advantages, and limitations and point out the need to combine experimental biology with computational tools able to describe complex biological systems and deliver results or predictions in the context of personalized medicine.Since their establishment, cell cultures have been proven to be the first and most powerful tool for the in vitro investigation of cell biology, from basic research to more complex translational approaches [6]. Classical two-dimensional (2D)-cultures usually consist of a unique type of cells (primary or continuous cultures) that grow in tissue culture polystyrene as adherent monolayers or in floating suspension, both in culture media that provide essential nutrients and growth factors. 2D-strategies are widely used to obtain a large number of cells, thus allowing the in vitro study of molecular mechanisms and development of metabolic assays [7-9]. However, due to their inability to recreate the in vivo complexity of the biological environment, they are not suitable for accurate disease modeling. These limitations have been overcome by the development of three-dimensional (3D)-cell cultures systems [10]. The rationale design of 3D-cell cultures is to harvest cells in microstructures that resemble tissues or organs shape and organization, thus allowing better cell-to-cell/cell-environment contacts and signaling crosstalk [11][12][13][14][15], essential events for tissues correct development and functioning [14,15]. The 3D-cell culture strategy is articulated in many different methods and techniques that can be grouped in scaffold-based or non-scaffold based platforms, each with particular advantages and disadvantages that make them useful for different applications [10,[16][17][18][19]. 3D-cell culture strategies are supported by the in silico...

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Nanocomposites Based on Biodegradable Polymers

Cited by 101 publications

References 156 publications

Polymeric Nanocomposites and Nanocoatings for Food Packaging: A Review

Polymeric Nanocomposites and Nanocoatings for Food Packaging: A Review

Biodegradable polymer nanocomposites for ligament/tendon tissue engineering

Harnessing the Potential of Stem Cells for Disease Modeling: Progress and Promises

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