Nanocomposites of gold nanoparticles and graphene oxide towards an stable label-free electrochemical immunosensor for detection of cardiac marker troponin-I

Liu, Guozhen; Meng, Qingda; Zhang, Yin; Cao, Chaomin; Goldys, Ewa M.

doi:10.1016/j.aca.2015.12.023

Cited by 133 publications

(59 citation statements)

References 46 publications

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“…for the POCT to capture the cTn biomarker [87]. In addition, the usage of a cTnI biomarker concentration, which resulted from experiments in a broad range of medical settings among various laboratories, is incomparable [88] due to matrix-blood sample interference in addition to the diversity in stability and selectivity of the biosensors' bio-receptors for cTnI detection [89,90].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…Electrical label-free biosensors have made a positive impression based on the latest accomplishments in terms of their capability for highly sensitive and selective detection of cTn biomarkers with additional advantages, as previously discussed. However, until the present, biosensors invented for cTnI biomarkers are still lacking in term of stability[87], with only limited literature available through translational research. A high-stability biosensor's transducer interface design is vital…”

mentioning

confidence: 98%

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Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

Fathil

Arshad

Ruslinda

et al. 2016

Analytica Chimica Acta

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

mentioning

confidence: 98%

Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

Fathil

Arshad

Ruslinda

et al. 2016

Analytica Chimica Acta

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“…Some research on the combination of graphene and AuNP has shown an enhanced electrochemical biosensor performance due to the unique properties of both materials [28][29][30][31][32]. Moreover, graphene can provide a cheap and large surface area for the AuNP deposition.…”

Section: Introductionmentioning

confidence: 98%

Competitive voltammetric morphine immunosensor using a gold nanoparticle decorated graphene electrode

Eissa

Zourob

2017

Microchim Acta

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The authors describe a voltammetric immunosensor for morphine (MOR) that is based on a graphene screen printed electrode (GSPE) modified with gold nanoparticles (AuNP) which were electrodeposited on its surface. The gold nanoparticles were characterized by scanning electron microscopy, Xray photoelectron spectroscopy and cyclic voltammetry. Cysteamine was then self-assembled on the gold-modified electrodes via thiol interaction in order to introduce terminal amino groups to the electrode surface. The electrodes were then used to fabricate the immunosensor by covalent immobilization of antibodies against MOR. The sensor works on the basis of a competition between MOR and the morphine-bovine serum albumin (MOR-BSA) conjugate for the immobilized antibodies on the sensor surface and the resulting change in the square wave voltammetry reduction current using the hexacyanoferrate system as an electrochemical probe. The competitive immunoassay enables sensitive and selective detection of MOR in the 0.1 to 100 ng·mL −1 MOR concentration range, with a 90 pg·mL −1 detection limit. The method was applied to the determination of MOR in spiked saliva samples and showed high recoveries. We believe that this immunosensor offers a simple, rapid, sensitive and accurate MOR test.

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“…These methods have greatly increased the uniformity and density of AuNPs. Liu et al 113 presented stable label-free EC sensor for detection of cardiac troponin-I (cTnI) in the early diagnosis of myocardial infarction based on AuNPs and GO nanocomposites. 113 The EC sensor demonstrated good selectivity and high sensitivity against human-cTnI, and was capable of detecting cTnI at concentrations as low as 0.05ngmL…”

Section: +mentioning

confidence: 99%

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

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The stability and dispersity of AuNMs in solution play a key role for the many applications. Most inorganic nanomaterials are not well dispersed in physiological buffers and require function-alization by thiols or surfactants to offer the stabilization forces. Furthermore, sufficient blood circulation time is critical for both imaging and in vivo drug delivery. Localized surface Plasmon resonance (LSPR) is one of the most significant features of AuNMs. The AuNMs as reporters have been broadly applied into lateral flow immunechromatographicalassay (LFICA) and enzyme-linked immunosorbent assay (ELISA), which is a well-established technology for analysis of the target analytes in food safety, clinical diagnosis, environmental monitoring, and medical science and so on. Au based nanomaterials (AuNMs) are known to possess many attractive features such as unique electrical, optical and catalytic properties as well as excellent biocompatibility. In this review, we summarize the current advancement on application of AuNMs in analytical sciences based on their local surface plasmon resonance, fluorescence and electrochemistry properties. AuNMs based imaging and therapy in biomolecules is explained. As one of the most reliable imaging modes, computed tomography (CT), X-ray and SERS imaging has been widely used owing to its high spatial and density resolution. We end the review by a discussion of the conjugation between gold nanoparticles with other kinds of nanoparticles such as other metals and carbon nano structures. Finally, future development in this research area is also prospected.

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Nanocomposites of gold nanoparticles and graphene oxide towards an stable label-free electrochemical immunosensor for detection of cardiac marker troponin-I

Cited by 133 publications

References 46 publications

Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

Competitive voltammetric morphine immunosensor using a gold nanoparticle decorated graphene electrode

Applications of gold nanoparticles in medicine and therapy

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