Nanocosmeceuticals for the management of ageing: Rigors and Vigors

Alsabeelah, Nimer; Arshad, Muhammad; Hashmi, Sana; Khan, R. A.; Khan, Shamshir

doi:10.1016/j.jddst.2021.102448

Cited by 10 publications

(3 citation statements)

References 134 publications

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“…Nanoparticles (NPs), which are too small for the naked eye to detect, have the potential to radically alter surfaces and structures by introducing cleaner, lighter, stronger, and “smarter” physical and chemical qualities [ 22 ]. The cosmetic industry was one of the first to adopt nanotechnology because of its considerable contribution to better skin penetration, stability, and component release through the skin barrier, which results in greater cosmetic effects [ 23 ]. Numerous cosmeceutical goods, including sunscreen, moisturizing and whitening creams, face cleansers, shampoos for hair repair, and anti-ageing products, contain nanotechnology [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Methyl-Anthranilate-Loaded Silver Nanoparticles: A Phytocosmetic Sunscreen Gel for UV Protection

et al. 2023

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Methyl anthranilate (MA) is a naturally derived compound commonly used in cosmetic products, such as skin care products, fine perfumes, etc. The goal of this research was to develop a UV-protective sunscreen gel using methyl-anthranilate-loaded silver nanoparticles (MA-AgNPs). The microwave approach was used to develop the MA-AgNPs, which were then optimized using Box–Behnken Design (BBD). Particle size (Y1) and absorbance (Y2) were chosen as the response variables, while AgNO3 (X1), methyl anthranilate concentration (X2), and microwave power (X3) were chosen as the independent variables. Additionally, the prepared AgNPs were approximated for investigations on in vitro active ingredient release, dermatokinetics, and confocal laser scanning microscopy (CLSM). The study’s findings showed that the optimal MA-loaded AgNPs formulation had a particle size, polydispersity index, zeta potential, and percentage entrapment efficiency (EE) of 200 nm, 0.296 mV, −25.34 mV, and 87.88%, respectively. The image from transmission electron microscopy (TEM) demonstrated the spherical shape of the nanoparticles. According to an in vitro investigation on active ingredient release, MA-AgNPs and MA suspension released the active ingredient at rates of 81.83% and 41.62%, respectively. The developed MA-AgNPs formulation was converted into a gel by using Carbopol 934 as a gelling agent. The spreadability and extrudability of MA-AgNPs gel were found to be 16.20 and 15.190, respectively, demonstrating that the gel may spread very easily across the skin’s surface. The MA-AgNPs formulation demonstrated improved antioxidant activity in comparison to pure MA. The MA-AgNPs sunscreen gel formulation displayed non-Newtonian pseudoplastic behaviour, which is typical of skin-care products, and was found to be stable during the stability studies. The sun protection factor (SPF) value of MA-AgNPG was found to be 35.75. In contrast to the hydroalcoholic Rhodamine B solution (5.0 µm), the CLSM of rat skin treated with the Rhodamine B-loaded AgNPs formulation showed a deeper penetration of 35.0 µm, indicating the AgNPs formulation was able to pass the barrier and reach the skin’s deeper layers for more efficient delivery of the active ingredient. This can help with skin conditions where deeper penetration is necessary for efficacy. Overall, the results indicated that the BBD-optimized MA-AgNPs provided some of the most important benefits over conventional MA formulations for the topical delivery of methyl anthranilate.

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Section: Introductionmentioning

confidence: 99%

Development and Characterization of Methyl-Anthranilate-Loaded Silver Nanoparticles: A Phytocosmetic Sunscreen Gel for UV Protection

et al. 2023

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“…The use of nanotechnology in antiaging cosmetics is the fastest growing segment in the skin care industry. These formulations include lipid-based, polymer-based, metal-based, and other nanosystems (dendrimers, fullerenes, and nanocrystals) [ 27 , 28 ]. Among them, lipid-based delivery systems (solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, and nanoemulsions) are considered advantageous compared to other nanosystems owing to their low toxicity, high drug loading capacity, biodegradability, large-scale manufacturing, and diverse chemical and formulation landscape [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, the identification of commercially available cosmetics based on nanotechnology is quite challenging. Moreover, there is a recognized need for research into the efficacy and safety with precise guidelines for manufacturing, advertising, nanotoxicological testing, and safe use of nanocosmetics [ 27 , 28 , 33 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

Milosheska¹,

Roškar

2022

Adv Ther

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Nowadays, numerous skincare routines are used to rejuvenate aging skin. Retinoids are one of the most popular ingredients used in antiaging treatments. Among the representatives of retinoids, tretinoin is considered the most effective agent with proven antiaging effects on the skin and can be found in formulations approved as medicines for topical treatment of acne, facial wrinkles, and hyperpigmentation. Other retinoids present in topical medicines are used for various indications, but only tazarotene is also approved as adjunctive agent for treatment of facial fine wrinkling and pigmentation. The most commonly used retinoids such as retinol, retinaldehyde, and retinyl palmitate are contained in cosmeceuticals regulated as cosmetics. Since clinical efficacy studies are not required for marketing cosmetic formulations, there are concerns about the efficacy of these retinoids.

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Formulations with Active Plant Molecules and Additional Therapies in Wound Healing

de Araujo,

Locatelli,

da Silva-López

et al. 2024

Rev. Bras. Farmacogn.

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Nanocosmeceuticals for the management of ageing: Rigors and Vigors

Cited by 10 publications

References 134 publications

Development and Characterization of Methyl-Anthranilate-Loaded Silver Nanoparticles: A Phytocosmetic Sunscreen Gel for UV Protection

Development and Characterization of Methyl-Anthranilate-Loaded Silver Nanoparticles: A Phytocosmetic Sunscreen Gel for UV Protection

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

Formulations with Active Plant Molecules and Additional Therapies in Wound Healing

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