Nanocrystalline hydroxyapatite doped with aluminium: A potential carrier for biomedical applications

Kolekar, Tanaji V.; Thorat, Nanasaheb D.; Yadav, Hemraj M.; Magalad, Veeresh T.; Shinde, Mahesh A.; Bandgar, Sneha S.; Kim, Jin Hee; Agawane, G.L.

doi:10.1016/j.ceramint.2015.12.060

Cited by 26 publications

(23 citation statements)

References 49 publications

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“…According to the XRD analysis, the powders consist of only the hydroxyapatite (JCPDS #09-432) phase with a low crystallinity degree ( Figure 1). We did not observe the formation of other phases in the case of even high Al substitution in contrast to the data of Kaygili et al, 4 6 Wang et al 10 demonstrated the presence of the only apatite phase in the case of 2.78 wt % of Al substitution, but further increase of Al amount resulted in the The Journal of Physical Chemistry B Article formation of impurity phases of CaHPO 4 , AlPO 4 , and Ca 3 (PO4) 2 in the case of the predicted Al content of 5.56 wt. %.…”

Section: Resultscontrasting

confidence: 99%

Influence of Al on the Structure and in Vitro Behavior of Hydroxyapatite Nanopowders

et al. 2019

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Nanopowders of aluminum-substituted (0−20 mol %) hydroxyapatite (HA) with the average size of 40−60 nm were synthesized by the precipitation method from nitrate solutions. A series of samples were studied by various analytical tools to elucidate the peculiarities of Al introduction. Electron paramagnetic resonance and pulsed electron-nuclear double resonance data demonstrate that incorporation of Al resulted in a decrease in the concentration of impurity carbonate anions and lead to an increase in the number of protons in the distant environment of the impurity nitrogen species. Density functional theory calculations show that the Al 3+ incorporation is accompanied by the local positional rearrangement and the distortion of anion channel geometry. An in vitro test conducted on MG-63 cells demonstrates the cytocompatibility and magnification of the surface matrix characteristics with Al doping.

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Section: Resultscontrasting

confidence: 99%

Influence of Al on the Structure and in Vitro Behavior of Hydroxyapatite Nanopowders

et al. 2019

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“…Furthermore, work by Kolekar et al . showed that Al doped hydroxyapatite was biocompatible with L929 mouse fibroblast cells in vitro …”

Section: Introductionmentioning

confidence: 99%

“…45 Furthermore, work by Kolekar et al showed that Al doped hydroxyapatite was biocompatible with L929 mouse fibroblast cells in vitro. 46 The development of complex tissue engineering products may require the integration of materials with different properties, yielding site-specific cellular adhesion, proliferation and differentiation, which motivates the creation of new polymers for precise microfabrication via LTPP. To the best of our knowledge, no LTPP-produced hybrid materials incorporating Al have yet been reported.…”

Section: Introductionmentioning

confidence: 99%

3D printing hybrid organometallic polymer‐based biomaterials via laser two‐photon polymerization

Balčiūnas

Baldock

Dreižė

et al. 2019

Polymer International

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Materials with microscale structures are gaining increasing interest due to their range of technical and medical applications. Additive manufacturing approaches to such objects via laser two‐photon polymerization, also known as multiphoton fabrication, enable the creation of new materials with diverse and tunable properties. Here, we investigate the properties of 3D structures composed of organometallic polymers incorporating aluminium, titanium, vanadium and zirconium. The organometallic polymer‐based materials were analysed using a variety of techniques including SEM, energy‐dispersive X‐ray spectroscopy, X‐ray photoelectron spectroscopy analysis and contact angle measurements and their biocompatibility was tested in vitro. Cell viability and mode of death were determined by 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay and acridine orange/ethidium bromide staining. Polymers incorporating Al, Ti and Zr supported cell adhesion and proliferation, and showed low toxicity in vitro, whereas the organometallic polymer incorporating V was shown to be cytotoxic. Inductively coupled plasma optical emission spectrometry suggested that leaching of the V from the organometallic polymer is the likely cause of this. The preparation of the organometallic polymers is straightforward and both simple 2D and complex 3D structures can be fabricated with ease. Resolution tests of the newly developed organometallic polymer incorporating Al show that suspended lines with widths down to 200 nm can be fabricated. We believe that the materials described in this work show promising properties for the development of objects with sub‐micron features for biomedical applications (e.g. biosensors, drug delivery devices, tissue scaffolds etc.). © 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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“…It was highlighted that the cell viability decreases gradually with the increasing Al 3+ concentration (tested in the range 0.5–2.5 at.%) and incubation time. Al-HA is biocompatible when added in an amount up to 1 mg mL −1 [263].…”

Section: Cation-substituted Hydroxyapatitesmentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

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High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

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Nanocrystalline hydroxyapatite doped with aluminium: A potential carrier for biomedical applications

Cited by 26 publications

References 49 publications

Influence of Al on the Structure and in Vitro Behavior of Hydroxyapatite Nanopowders

Influence of Al on the Structure and in Vitro Behavior of Hydroxyapatite Nanopowders

3D printing hybrid organometallic polymer‐based biomaterials via laser two‐photon polymerization

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

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