Nanocrystals as an emerging nanocarrier for the management of dermatological diseases

Parveen, Neha; Abourehab, Mohammed A.S.; Veeraveedu, Punniyakoti T.; Khar, Roop K.; Kesharwani, Prashant

doi:10.1016/j.colsurfb.2023.113231

Cited by 16 publications

(3 citation statements)

References 86 publications

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“…NCs under the range of 100-1000 nm are biodegradable in nature and impart less toxicity while NCs are >100 nm can be taken up by all kinds of cells by endocytosis mechanism therefore it possesses high toxicity risk as compared to NCs of larger size. [107] Cytotoxicity is another major concern related to NCs, as nanotization can develop smaller particles with differential charges on surface. NCs exhibit cytotoxicity when it targets different cells especially mononuclear phagocytes (MPs) other than targeted ligands.…”

Section: Challenges and Future Perspective Associated With Ncsmentioning

confidence: 99%

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Nanocrystals: A Multifaceted Regimen for Dermatological Ailments

Giradkar,

Mhaske,

Shukla

2024

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Skin disorders are the most common apprehension worldwide among different regions of the world. Topical route of administration offers benefits over other routes such as avoidance of first‐pass metabolism, low dose, longer residence time, and absence of off‐target delivery. Skin serves as a mechanical barrier for therapeutic delivery with selectively permeable essential molecules. Considering the structural complexity of skin, delivery of therapeutics at targeted site requires sophisticated method such as nanotechnology‐assisted therapeutic delivery. The roadmap for combinatorial approach of nanotechnology and skin therapeutics has proven significant in clinical and marketed products. Currently, various pharmaceutical aids such as nanocrystal (NCs), nanoparticles, nanoemulsion, nano‐micelles, nano lipidic carriers, and hybrid nanocarriers are currently in market. Among all the other nanocarriers, nanocrystal offers precedence over other nanocarriers due to its facile method of preparation, reproducibility, low excipient concentration, and high therapeutic loading capacity. The recent literature data suggest the breakthrough evolution of NCs in topical therapeutic delivery. The outcome of these interventions envisages the applicability of NCs for delivering molecules with compromised physicochemical characteristics such as solubility, stability, toxicity, and bioavailability concerns.

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Section: Challenges and Future Perspective Associated With Ncsmentioning

confidence: 99%

“…NCs under the range of 100–1000 nm are biodegradable in nature and impart less toxicity while NCs are >100 nm can be taken up by all kinds of cells by endocytosis mechanism therefore it possesses high toxicity risk as compared to NCs of larger size. [ 107 ]…”

Section: Challenges and Future Perspective Associated With Ncsmentioning

confidence: 99%

Nanocrystals: A Multifaceted Regimen for Dermatological Ailments

Giradkar,

Mhaske,

Shukla

2024

Part & Part Syst Charact

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“…Particle size reduction to the nanoscale facilitates high drug loading in the preparation by dispersing the insoluble compounds in a solid state with low apparent viscosity [ 11 ]. Moreover, a decrease in particle size leads to an increase in the surface area, which is favorable for the adhesion of drug particles to biological membranes [ 12 ]. Moreover, the increased dissolution rate and drug concentration gradient between the stratum corneum and external preparations allow for higher penetration into the skin layer [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Design of High-Payload Ascorbyl Palmitate Nanosuspensions for Enhanced Skin Delivery

Park,

Choi,

Joung

et al. 2024

Pharmaceutics

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A high-payload ascorbyl palmitate (AP) nanosuspension (NS) was designed to improve skin delivery following topical application. The AP-loaded NS systems were prepared using the bead-milling technique, and softly thickened into NS-loaded gel (NS-G) using hydrophilic polymers. The optimized NS-G system consisted of up to 75 mg/mL of AP, 0.5% w/v of polyoxyl-40 hydrogenated castor oil (Kolliphor® RH40) as the suspending agent, and 1.0% w/v of sodium carboxymethyl cellulose (Na.CMC 700 K) as the thickening agent, in citrate buffer (pH 4.5). The NS-G system was embodied as follows: long and flaky nanocrystals, 493.2 nm in size, −48.7 mV in zeta potential, and 2.3 cP of viscosity with a shear rate of 100 s−1. Both NS and NS-G provided rapid dissolution of the poorly water-soluble antioxidant, which was comparable to that of the microemulsion gel (ME-G) containing AP in solubilized form. In an ex vivo skin absorption study using the Franz diffusion cell mounted on porcine skin, NS-G exhibited faster absorption in skin, providing approximately 4, 3, and 1.4 times larger accumulation than that of ME-G at 3, 6, and 12 h, respectively. Therefore, the high-payload NS makes it a promising platform for skin delivery of the lipid derivative of ascorbic acid.

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