NanoCT: Visualizing of Internal 3D-Structures with Submicrometer Resolution

Brockdorf, Kathleen; Brunke, Oliver; Neuber, Dirk

doi:10.1017/s1431927607072170

Cited by 1 publication

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“…The detector is mounted on a rail system in order to allow movement to different horizontal positions, thereby increasing the overall field of view (FOV). Using this feature, a standard 12 cm × 12 cm detector can move to multiple positions to create a virtual 12 cm × 36 cm detector (27). Utilizing this feature, we have been able to image cross-sections of human diaphyseal bone at 5 microns and clearly visualize and quantify the intra-cortical porosity (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Due to drastically increased power and a nano-focused beam, nanoCT systems are capable of higher resolution, increased signal-to-noise ratio (SNR) and reduced imaging time (27). Importantly, the nano-focused X-ray beam significantly improved the image quality for samples scanned in the 5-15 micron voxel size range, which is the range most often used by conventional microCT systems.…”

Section: Introductionmentioning

confidence: 99%

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The use of nano-computed tomography to enhance musculoskeletal research

Khoury¹,

Bigelow

Smith

et al. 2015

Connective Tissue Research

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Advances in computed tomography (CT) imaging are opening new avenues toward more precise characterization and quantification of connective tissue microarchitecture. In the last two decades, micro-computed tomography (microCT) has significantly augmented destructive methods for the 3D micro-analysis of tissue structure, primarily in the bone research field. Recently, microCT has been employed in combination with contrast agents to generate contrast-enhanced images of soft tissues that are otherwise difficult to visualize due to their native radiodensity. More recent advances in CT technology have enabled ultra-high resolution imaging by utilizing a more powerful nano-focused X-ray source, such as that found in nano-computed tomography (nanoCT) systems. NanoCT imaging has facilitated the expansion of musculoskeletal research by reducing acquisition time and significantly expanding the range of samples that can be imaged in terms of size, age and tissue-type (bone, muscle, tendon, cartilage, vessels and adipose tissue). We present the application and early results of nanoCT imaging in various tissue types and how this ultra-high resolution imaging modality is capable of characterizing microstructures at levels of details previously not possible. Contrast-enhanced imaging techniques to enable soft-tissue visualization and characterization are also outlined.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%