2015
DOI: 10.1371/journal.pone.0139121
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Nanocurcumin Prevents Hypoxia Induced Stress in Primary Human Ventricular Cardiomyocytes by Maintaining Mitochondrial Homeostasis

Abstract: Hypoxia induced oxidative stress incurs pathophysiological changes in hypertrophied cardiomyocytes by promoting translocation of p53 to mitochondria. Here, we investigate the cardio-protective efficacy of nanocurcumin in protecting primary human ventricular cardiomyocytes (HVCM) from hypoxia induced damages. Hypoxia induced hypertrophy was confirmed by FITC-phenylalanine uptake assay, atrial natriuretic factor (ANF) levels and cell size measurements. Hypoxia induced translocation of p53 was investigated by usi… Show more

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Cited by 25 publications
(23 citation statements)
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“…Although our prior studies proved that TXL had infarct-sparing effect during I/R in animals, it remained unclear whether TXL could protect human cardiomyocytes from reperfusion injury. As a consequence, for our in vitro experiments, we used human cardiomyocytes, which are widely employed in cardiovascular research (Albrecht-Schgoer et al, 2012;Boon et al, 2013;Baker et al, 2015;Kuo et al, 2015;Nehra et al, 2015;Sharma et al, 2015), rather than cardiomyocytes isolated from animals.…”
Section: Discussionmentioning
confidence: 99%
“…Although our prior studies proved that TXL had infarct-sparing effect during I/R in animals, it remained unclear whether TXL could protect human cardiomyocytes from reperfusion injury. As a consequence, for our in vitro experiments, we used human cardiomyocytes, which are widely employed in cardiovascular research (Albrecht-Schgoer et al, 2012;Boon et al, 2013;Baker et al, 2015;Kuo et al, 2015;Nehra et al, 2015;Sharma et al, 2015), rather than cardiomyocytes isolated from animals.…”
Section: Discussionmentioning
confidence: 99%
“…Cardiac hypertrophy promoted by hypoxia in these cells showed a decline in nanocurcumin treated cardiomyocytes and these cells were found to be more viable [44] .Also shift of energy source of cardiomyocytes from lipids to glucose under hypoxic conditions was hampered by nanocurcumin and mitochondrial function was conserved by nanocurcumin in hypoxic conditions [44] .…”
Section: Curcumin In Gastrointestinal Disorders:-mentioning
confidence: 99%
“…Curcumin and cardiovascular system:-In a study done on human ventricular cardiomyocytes (HVCM), nanocurcumin at a dose of 500 ng/ml was shown to have cardioprotective action [44] . Cardiac hypertrophy promoted by hypoxia in these cells showed a decline in nanocurcumin treated cardiomyocytes and these cells were found to be more viable [44] .Also shift of energy source of cardiomyocytes from lipids to glucose under hypoxic conditions was hampered by nanocurcumin and mitochondrial function was conserved by nanocurcumin in hypoxic conditions [44] .…”
Section: Curcumin In Gastrointestinal Disorders:-mentioning
confidence: 99%
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“…Cardiomyocytes exposed to prolonged periods of hypoxia are induced to hypertrophy. Such hypertrophy leads to impaired mitochondrial homeostasis causing pathological damage [109][110][111]. The nuclear genome in general encodes proteins for the regulation of mitochondrial functions such as electron transport chain (complexes I-V) [112].…”
Section: In Vitro Hypoxia Studiesmentioning
confidence: 99%