Nanodelivery systems for cutaneous melanoma treatment

Pereira, Irina; Monteiro, Carina; Pereira-Silva, Miguel; Peixoto, Diana; Nunes, Cláudia; Reis, Salette; Veiga, Francisco; Hamblin, Michael R.; Paiva‐Santos, Ana Cláudia

doi:10.1016/j.ejpb.2023.02.002

Cited by 14 publications

(5 citation statements)

References 159 publications

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“…Additionally, activated ERK is responsible for initiating a negative feedback loop at various levels of the MAPK pathway to regulate its activity. Furthermore, RTK-ligand interactions can also trigger the activation of other intracellular pathways, such as the phosphatidylinositol-3-kinase (PI3K) pathway [ 111 , 112 ].…”

Section: Mechanism Of Skin Cancer Progressionmentioning

confidence: 99%

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Hasan,

Nadaf,

Imran

et al. 2023

Mol Cancer

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Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination therapy, molecular targets associated with cancer growth and metastasis, and special emphasis on nanotechnology-based approaches for downregulating the deleterious disease. A detailed analysis with respect to types of nanoparticles and their scope in overcoming multidrug resistance as well as associated clinical trials has been discussed. Graphical Abstract

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Section: Mechanism Of Skin Cancer Progressionmentioning

confidence: 99%

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Hasan,

Nadaf,

Imran

et al. 2023

Mol Cancer

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“…In spite of our expectation that the results of RT-PCR on A-431 cells may be considerably different from the animal studies due to the suppression of inflammatory cascade pathway outside the keratinocytes and perhaps in immune cells, but they even showed clearer and more reliable results (Figure 5 ). This may demonstrate that most of the inflammatory interactions will happen in the keratinocytes themselves, even though they have an effect on other cells, especially immune cells [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Keratinocyte Exosomes for Topical Delivery of Tofacitinib in Treatment of Psoriasis: an In Vitro/ In Vivo Study in Animal Model of Psoriasis

Dehghani,

Varshosaz,

Mirian

et al. 2024

Pharm Res

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Introduction Exosomes are extracellular vesicles in the range of 40-150 nm released from the cell membrane. Exosomes secreted by keratinocytes can communicate with other keratinocytes and immune cells with specific biomarkers at their surface, which may be effective on inflammation of psoriasis and its pathogenesis. Objective The present study aimed to formulate and study effectiveness of an exosomal delivery system of tofacitinib (TFC). Methods TFC was loaded by different methods in exosomes and then characterized for particle size, zeta potential, drug loading efficiency, and release efficiency. By comparing these parameters, the probe sonication method was chosen to load TFC into exosomes. The MTT assay was used to compare the cytotoxicity of the free drug with the TFC-loaded exosomes (TFC-Exo), and Real-time PCR was used to determine the expression levels of several genes involved in psoriasis expressed in the A-431 keratinocyte and their suppression after treatment. Animal model of psoriasis was induced in BALB/c mice by imiquimod and the efficacy of free TFC, and TFC-Exo were studies on macroscopic appearance and histopathological symptoms. Results Exosomes encapsulating TFC showed lower cytotoxicity in MTT assay, higher suppression the expression of TNF-a, IL-23, IL-6, and IL-15 genes in real-time PCR and better therapeutic effect on animal models compered to free TFC. Conclusions This method of drug delivery for TFC may be effective on enhancing its therapeutic effects and reduction its side effects favorably in chronic administration. Graphical abstract

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“…It is obvious that there are numerous approaches to intervene the process of PMN through directly targeting fibroblasts. Although engineering therapeutic strategies including nano-delivery technology and in vivo RNA interference technology have made unprecedented progress in precisely targeting the activation of fibroblast, the application of these engineered biological therapeutic routes is still limited due to the relatively low delivery efficiency and safety [138][139][140]. Meanwhile, the targeted delivery of nucleic acid substances including RNA in vivo still faces the challenge of low bioavailability [141,142], which remains an urgent issue to be addressed in future studies [143].…”

Section: Fibroblast Based-therapies For Modulating Pmn Formationmentioning

confidence: 99%

Fibroblasts: invigorated targets in pre-metastatic niche formation

Han,

Qian,

Song

et al. 2024

Int. J. Biol. Sci.

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At present, tumor metastasis still remains the leading contributor to high recurrence and mortality in cancer patients. There have been no clinically effective therapeutic strategies for treating patients with metastatic cancer. In recent years, a growing body of evidence has shown that the pre-metastatic niche (PMN) plays a crucial role in driving tumor metastasis. Nevertheless, a clear and detailed understanding of the formation of PMN is still lacking given the fact that PMN formation involves in a wealth of complicated communications and underlying mechanisms between primary tumors and metastatic target organs. Despite that the roles of numerous components including tumor exosomes and extracellular vesicles in influencing the evolution of PMN have been well documented, the involvement of cancer-associated fibroblasts (CAFs) in the tumor microenvironment for controlling PMN formation is frequently overlooked. It has been increasingly recognized that fibroblasts trigger the formation of PMN by virtue of modulating exosomes, metabolism and so on. In this review, we mainly summarize the underlying mechanisms of fibroblasts from diverse origins in exerting impacts on PMN evolution, and further highlight the prospective strategies for targeting fibroblasts to prevent PMN formation.

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Nanodelivery systems for cutaneous melanoma treatment

Cited by 14 publications

References 159 publications

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Keratinocyte Exosomes for Topical Delivery of Tofacitinib in Treatment of Psoriasis: an In Vitro/ In Vivo Study in Animal Model of Psoriasis

Fibroblasts: invigorated targets in pre-metastatic niche formation

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