Nanodevices for deep cartilage penetration

Xu, Xiaoling; Xue, Yan; Ding, Jia-Ying; Zhu, Zhi-Heng; Wu, Xi-Chen; Song, Yong-Jia; Cao, Yuelong; Tang, Longguang; Ding, Daofang; Xu, Jian‐Guang

doi:10.1016/j.actbio.2022.10.007

Cited by 18 publications

(14 citation statements)

References 162 publications

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“…Another critical aspect of successful cartilage regeneration is the delivery and retention of therapeutic agents within the cartilage tissue. 67 , 68 Plant ELNs can serve as carriers for therapeutic molecules, overcoming challenges such as poor penetration and limited retention within the avascular cartilage. Due to their small size, plant ELNs can penetrate deep into the cartilage matrix, ensuring efficient delivery of therapeutic cargo.…”

Section: Application Of Plant Elns In Promotion Of Different Tissue R...mentioning

confidence: 99%

Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering

Feng,

Yue,

Zhang

et al. 2024

IJN

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Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in tissue engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied in clinical disease management, especially for tissue regeneration. In this review, we comprehensively examine the properties, characteristics, and isolation techniques of plant ELNs. We also discuss their impact on the immune system, compatibility with the human body, and their role in tissue regeneration. To ensure the suitability of plant ELNs for tissue engineering, we explore various engineering and modification strategies. Additionally, we provide insights into the progress of commercialization and industrial perspectives on plant ELNs. This review aims to highlight the potential of plant ELNs in regenerative medicine by exploring the current research landscape and key findings.

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Section: Application Of Plant Elns In Promotion Of Different Tissue R...mentioning

confidence: 99%

Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering

Feng,

Yue,

Zhang

et al. 2024

IJN

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“…Small particles like liposomes are rapidly cleared from synovium and therefore the administration of larger particles is preferable [29]. Cationic vehicles have been recently used to enhance interaction with negatively charged cartilage surface [48,49], but liposomes containing high amounts of positively charged phospholipids can elicit toxicity and inflammation [50,51]. To avoid this, we devised a liposomal formulation with anionic phospholipids that aggregate after the addition of Zn 2+ , resulting in slightly positively charged ZnALs in µm-range (Figures 2b), c)).…”

Section: Fabrication and Characterisation Of Zinc Aggregated Liposome...mentioning

confidence: 99%

Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction

Bordon

Ramakrishna

Edalat³

et al. 2023

Preprint

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Fibrosis, low-grade inflammation, and increased friction are together with degradation of cartilage key culprits for debilitating pain in osteoarthritis (OA), which is one of the most common chronic diseases of today's aging population. Intraarticular administration of bio-lubricants loaded with a pharmaceutically active component recently showed promise to improve therapy. Liposomes have emerged as exceptional lubricant biomaterial, but their small size leads to rapid clearance from the synovium, causing a need for more frequent administration. We recently developed a liposomal drug delivery system based on aggregation of negatively charged liposomes with physiologically present divalent cations. Here, we expanded our platform by replacing calcium with zinc, reported to exert anti-inflammatory action. The liposomal aggregates extend the release of rapamycin (RAPA) beyond the free liposomes and have a diameter of nearly 100 um, which was previously established to improve retention in synovial joints. Electron microscopy showed that RAPA alters the irregular morphology of liposomal clusters, which are irreversible upon dilution. RAPA recently showed great promise both in vitro and in vivo at protecting the joints from inflammation and cartilage from further degradation. Our study adds to this by showing that RAPA is also able to dampen the fibrotic response in human OA synovial fibroblasts. Finally, the tribological properties were assessed on nano- and macro-scales on silicon surface and ex vivo porcine cartilage, which showed an excellent protective ability of the system against friction on both scales. Taken together, our study shows that liposomal aggregates have the potential of improving local OA therapy.

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“…36,37 In view of the negatively charged properties of cartilage matrix, there have been relevant reports confirming that the modification of drugs by positively charged nanoparticles can overcome the obstacle of drugs with difficulty in penetrating cartilage and effectively improve the utilization of drugs. 38–40 The pH responsive cationic N , N -dimethylaminoethyl methacrylate (DMAEMA) can not only effectively overcome the dense structural obstacles and negatively charged cartilage, penetrate the cartilage matrix, but also closely bind hydrophilic anti-inflammatory drugs through electrostatic interaction and trigger the controllable release of drugs in joint inflammation sites, is widely used as a carrier for drug delivery in OA treatment. 41–43…”

Section: Introductionmentioning

confidence: 99%

A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment

Zhang

Yuan

et al. 2023

Mater. Horiz.

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Nanodevices for deep cartilage penetration

Cited by 18 publications

References 162 publications

Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering

Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering

Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction

A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment

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