Nanodiamond‐chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity

Saha, Tanushree; Houshyar, Shadi; Sarker, Satya Ranjan; Pyreddy, Suneela; Dekiwadia, Chaitali; Nasa, Zeyad; Padhye, Rajiv; Wang, Xin

doi:10.1002/jbm.a.37237

Cited by 16 publications

(14 citation statements)

References 74 publications

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“…Therefore, heat treatment increases the time for showing hydrophilicity of the visceral sides. However, it conserves the same cellular response observed in our previous work, [20] indicating no detrimental effect on PMPC due to heat treatment.…”

Section: Surface Characterizationsupporting

confidence: 82%

A Biocompatible Dual‐Sided Hernia Mesh with Side‐Specific Properties

Saha

Sarker

Dekiwadia

et al. 2023

Adv Materials Technologies

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Polypropylene (PP) based hernia mesh often shows multiple post‐surgery complications due to lack of biocompatibility, poor cell attachment, and unwanted tissue adhesion. These limitations can be addressed by material designing and surface modification of a mesh with side‐specific properties such as the visceral side (facing intestine) with low protein and cell attachment and the parietal side (facing incision) with improved cell attachment properties for normal healing. However, the development of dual‐sided mesh is very challenging because of its porous structure. Herein, a dual‐sided biocompatible mesh with protein anti‐adsorption and cell attachment properties on two different sides is developed by grafting highly hydrophilic 2‐methcryloyloxyethyl phosphorylcholine polymer (PMPC) on the plasma‐activated visceral side, while the parietal side is coated with bioactive chitosan and functionalized nanodiamond (Chi/FND) using a temporary polyvinyl alcohol (PVA) mold. The PMPC‐grafted side demonstrated excellent resistance to protein adsorption (96% reduction compared to PP) and cell attachment. However, the bioactive coating on the parietal side has significantly improved cell attachment and proliferation properties. In addition, both sides confirmed the presence of the respective biomaterials after an accelerated degradation study for 28 days. Hence, the newly developed dual‐sided mesh by semi‐solid polymer mold (SSPM) method is a promising candidate to address the long‐existing multiple issues of hernia mesh.

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Section: Surface Characterizationsupporting

confidence: 82%

A Biocompatible Dual‐Sided Hernia Mesh with Side‐Specific Properties

Saha

Sarker

Dekiwadia

et al. 2023

Adv Materials Technologies

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“…Although the mechanical properties of untreated PP surgical meshes have been previously reported, , the application of treatments to improve the healing process and reduce hernia recurrence (e.g., chemical etching and coating with another biocompatible substance , ) affect the suture resistance and burst forces, which influence the final application of such biomedical devices . The bursting test, which evaluates the tensile strength of constrained meshes subjected to a perpendicular force, examines the ability of the implants to withstand biaxial loading that may be encountered during changes in intra-abdominal pressure in vivo.…”

Section: Resultsmentioning

confidence: 99%

Mechanical Properties of Smart Polypropylene Meshes: Effects of Mesh Architecture, Plasma Treatment, Thermosensitive Coating, and Sterilization Process

Lanzalaco

Weis

Traeger

et al. 2023

ACS Biomater. Sci. Eng.

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Smart polypropylene (PP) hernia meshes were proposed to detect surgical infections and to regulate cell attachment-modulated properties. For this purpose, lightweight and midweight meshes were modified by applying a plasma treatment for subsequent grafting of a thermosensitive hydrogel, poly(N-isopropylacrylamide) (PNIPAAm). However, both the physical treatment with plasma and the chemical processes required for the covalent incorporation of PNIPAAm can modify the mechanical properties of the mesh and thus have an influence in hernia repair procedures. In this work, the mechanical performance of plasma-treated and hydrogel-grafted meshes preheated at 37 °C has been compared with standard meshes using bursting and the suture pull out tests. Furthermore, the influence of the mesh architecture, the amount of grafted hydrogel, and the sterilization process on such properties have been examined. Results reveal that although the plasma treatment reduces the bursting and suture pull out forces, the thermosensitive hydrogel improves the mechanical resistance of the meshes. Moreover, the mechanical performance of the meshes coated with the PNIPAAm hydrogel is not influenced by ethylene oxide gas sterilization. Micrographs of the broken meshes evidence the role of the hydrogel as reinforcing coating for the PP filaments. Overall, results confirm that the modification of PP medical textiles with a biocompatible thermosensitive hydrogel do not affect, and even improve, the mechanical requirements necessary for the implantation of these prostheses in vivo.

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“…However, there are still some cases of rejection due to foreign-body reactions and infections of the area [51]. These polypropylene-based meshes have been modified by including chitosan on their surface, which improves biocompatibility and antimicrobial properties, thus accelerating the healing process [52]. This synergy needs to be explored more deeply; another study evaluated the coating of polypropylene meshes with different concentrations of chitosan, but when they were implanted in rats, the adhesion and histopathological parameters were not modified [53].…”

Section: Meshesmentioning

confidence: 99%

Applications of Chitosan in Surgical and Post-Surgical Materials

et al. 2022

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The continuous advances in surgical procedures require continuous research regarding materials with surgical applications. Biopolymers are widely studied since they usually provide a biocompatible, biodegradable, and non-toxic material. Among them, chitosan is a promising material for the development of formulations and devices with surgical applications due to its intrinsic bacteriostatic, fungistatic, hemostatic, and analgesic properties. A wide range of products has been manufactured with this polymer, including scaffolds, sponges, hydrogels, meshes, membranes, sutures, fibers, and nanoparticles. The growing interest of researchers in the use of chitosan-based materials for tissue regeneration is obvious due to extensive research in the application of chitosan for the regeneration of bone, nervous tissue, cartilage, and soft tissues. Chitosan can serve as a substance for the administration of cell-growth promoters, as well as a support for cellular growth. Another interesting application of chitosan is hemostasis control, with remarkable results in studies comparing the use of chitosan-based dressings with traditional cotton gauzes. In addition, chitosan-based or chitosan-coated surgical materials provide the formulation with antimicrobial activity that has been highly appreciated not only in dressings but also for surgical sutures or meshes.

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Nanodiamond‐chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity

Cited by 16 publications

References 74 publications

A Biocompatible Dual‐Sided Hernia Mesh with Side‐Specific Properties

A Biocompatible Dual‐Sided Hernia Mesh with Side‐Specific Properties

Mechanical Properties of Smart Polypropylene Meshes: Effects of Mesh Architecture, Plasma Treatment, Thermosensitive Coating, and Sterilization Process

Applications of Chitosan in Surgical and Post-Surgical Materials

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