Nanodiamond/poly-ε-caprolactone nanofibrous scaffold for wound management

Houshyar, Shadi; Kumar, G. Sathish; Rifai, Aaqil; Tran, Nhiem; Nayak, Rajkishore; Shanks, Robert A.; Padhye, Rajiv; Fox, Kate; Bhattacharyya, Amitava

doi:10.1016/j.msec.2019.02.110

Cited by 44 publications

(52 citation statements)

References 45 publications

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“…PCL as a quintessential synthetic thermoplastic that possesses extremely outstanding properties, such as sluggish rate of biodegradability, biocompatible towards numerous materials, thermal stability and can be readily modified. On the account of these phenomenal facets, PCL has been considered as a superb biomaterial, which can be employed in various biomedical applications (viz., scaffolds for tissue re-engineering, wound dressing and targeted drug delivery systems) [25,52,53]. In addition, the incorporation of a foreign nanoparticle into the PCL matrix can result in the alteration of virtually all the native properties of PCL and account for a specific improvement in which the biomedical utility of the resultant PCL/nanofiber composites can be broadly expanded.…”

Section: Biomedical Indispensability Of the Pcl Electrospun Nanocompomentioning

confidence: 99%

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

et al. 2019

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Polycaprolactone (PCL) is one of the most used synthetic polymers for medical applications due to its biocompatibility and slow biodegradation character. Combining the inherent properties of the PCL matrix with the characteristic of nanofibrous particles, result into promising materials that can be suitable for different applications, including the biomedical applications. The advantages of nanofibrous structures include large surface area, a small diameter of pores and a high porosity, which make them of great interest in different applications. Electrospinning, as technique, has been heavily used for the preparation of nano- and micro-sized fibers. This review discusses the different methods for the electrospinning of PCL and its composites for advanced applications. Furthermore, the steady state conditions as well as the effect of the electrospinning parameters on the resultant morphology of the electrospun fiber are also reported.

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Section: Biomedical Indispensability Of the Pcl Electrospun Nanocompomentioning

confidence: 99%

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

et al. 2019

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“…There is a growing need for effective scaffolds for tissue regeneration in biomaterials research, with requirements including biocompatibility, strength, and structure. Detonation nanodiamonds (NDs) are gaining significant interest for their mechanical strength, optical properties, and biocompatibility [1][2][3][4]. NDs have been assessed for biocompatibility both in vitro and in vivo with positive outcomes such as low cytotoxicity [5][6][7], improved cellular adhesion [8], and improved cell proliferation [3].…”

Section: Introductionmentioning

confidence: 99%

“…Detonation nanodiamonds (NDs) are gaining significant interest for their mechanical strength, optical properties, and biocompatibility [1][2][3][4]. NDs have been assessed for biocompatibility both in vitro and in vivo with positive outcomes such as low cytotoxicity [5][6][7], improved cellular adhesion [8], and improved cell proliferation [3]. They are significantly less cytotoxic than other carbon-based nanoparticles such as CNTs [7], and endocytic NDs are non-cytotoxic during cell division and differentiation [9].…”

Section: Introductionmentioning

confidence: 99%

“…Polycaprolactone (PCL) is an FDA-approved polyester widely studied for soft and hard tissue engineering scaffolds because of its non-toxic nature, degradability, and low melting temperature [24]. Despite those excellent properties, this polymer still possesses limitations, including a slow degradation time (2-3 years in interstitial fluid [25]), low mechanical strength, and high hydrophobicity [26,27], which hinder cell interactions [3,4,25]. Co-polymers and blended polymer composites are shown to improve PCL properties, particularly to tailor degradation properties [28].…”

Section: Introductionmentioning

confidence: 99%

“…We chose osteoblasts as a relevant cell type since the composite scaffolds we form herein are aimed for bone regeneration e.g., maxillofacial surgical implants. This builds upon more traditional ND-PCL film fabrication methods such as evaporation giving free-standing thin films [4] and electrospinning [3,21,31]. Herein we instead use additive manufacturing thermal extrusion-based 3D printing to show spatial control of the ND-PCL composites.…”

Section: Introductionmentioning

confidence: 99%

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High Nanodiamond Content-PCL Composite for Tissue Engineering Scaffolds

et al. 2020

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Multifunctional scaffolds are becoming increasingly important in the field of tissue engineering. In this research, a composite material is developed using polycaprolactone (PCL) and detonation nanodiamond (ND) to take advantage of the unique properties of ND and the biodegradability of PCL polymer. Different ND loading concentrations are investigated, and the physicochemical properties of the composites are characterized. ND-PCL composite films show a higher surface roughness and hydrophilicity than PCL alone, with a slight decrease in tensile strength and a significant increase in degradation. Higher loading of ND also shows a higher osteoblast adhesion than the PCL alone sample. Finally, we show that the ND-PCL composites are successfully extruded to create a 3D scaffold demonstrating their potential as a composite material for tissue regeneration.

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Materials Design Innovations in Optimizing Cellular Behavior on Melt Electrowritten (MEW) Scaffolds

Devlin,

Allenby,

Ren

et al. 2024

Adv Funct Materials

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The field of melt electrowriting (MEW) has seen significant progress, bringing innovative advancements to the fabrication of biomaterial scaffolds, and creating new possibilities for applications in tissue engineering and beyond. Multidisciplinary collaboration across materials science, computational modeling, AI, bioprinting, microfluidics, and dynamic culture systems offers promising new opportunities to gain deeper insights into complex biological systems. As the focus shifts towards personalized medicine and reduced reliance on animal models, the multidisciplinary approach becomes indispensable. This review provides a concise overview of current strategies and innovations in controlling and optimizing cellular responses to MEW scaffolds, highlighting the potential of scaffold material, MEW architecture, and computational modeling tools to accelerate the development of efficient biomimetic systems. Innovations in material science and the incorporation of biologics into MEW scaffolds have shown great potential in adding biomimetic complexity to engineered biological systems. These techniques pave the way for exciting possibilities for tissue modeling and regeneration, personalized drug screening, and cell therapies.

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Nanodiamond/poly-ε-caprolactone nanofibrous scaffold for wound management

Cited by 44 publications

References 45 publications

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

High Nanodiamond Content-PCL Composite for Tissue Engineering Scaffolds

Materials Design Innovations in Optimizing Cellular Behavior on Melt Electrowritten (MEW) Scaffolds

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