Nanodiamonds as traps for fibroblast growth factors: Parameters influencing the interaction

Mikešová, Jana; Miliaieva, Daria; Štenclová, Pavla; Kindermann, Marek; Vučková, Tereza; Mádlíková, Marcela; Fábry, Milan; Veverka, Václav; Schimer, Jiří; Krejčı́, Pavel; Stehlík, Štěpán; Cígler, Petr

doi:10.1016/j.carbon.2022.04.017

Cited by 13 publications

(17 citation statements)

References 66 publications

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“…Such a finding is in good agreement with reports about hydrogenated nanodiamonds bearing an sp 2 ‐phase at their surface. [ 46,52,57,58 ] The Raman spectra recently reported by Mikesova et al on the same type of nanodiamonds depicted a significant amount of non‐ sp 3 carbon manifested by the presence of a pronounced G‐band and attributed to graphitic content in the case of HPHT ND‐ar. The purification of HPHT ND‐ar by air annealing considerably reduced the intensity of the non‐ sp 3 carbon band and there is only remaining isolated sp 2 carbon on HPHT ND‐O.…”

Section: Resultsmentioning

confidence: 90%

“…[ 42–45 ] The residual oxygen content on the HPHT ND‐O‐H is less than 2 at% which confirms nearly complete hydrogenation. [ 46 ]…”

Section: Resultsmentioning

confidence: 99%

“…Then, the feature's intensity increases again after hydrogenation of the purified HPHT ND‐O and this corresponds to the formation of new sp 2 phase in HPHT ND‐O‐H as a result of the surface reorganization after the hydrogenation. [ 46 ] One suggestion of the surface‐conductive sp 2 phase could be the trans‐polyacetylene (TPA) chains [ 59 ] that have been indicated by the Raman spectroscopy on the same HPHT ND‐O‐H sample. [ 46,60 ] In other words, while it is plausible that charge conduction processes will mostly take place at the surface of carbon nanodiamonds.…”

Section: Resultsmentioning

confidence: 99%

“…[ 46 ] One suggestion of the surface‐conductive sp 2 phase could be the trans‐polyacetylene (TPA) chains [ 59 ] that have been indicated by the Raman spectroscopy on the same HPHT ND‐O‐H sample. [ 46,60 ] In other words, while it is plausible that charge conduction processes will mostly take place at the surface of carbon nanodiamonds. In principle, the current is flowing near the surface of any conductor.…”

Section: Resultsmentioning

confidence: 99%

“…Since the zeta potential of the ITO substrate is positive at neutral pH values, [ 61 ] it electrostatically attracts the negatively charged oxidized NDs (HPHT ND‐ar and HPHT ND‐O) but repels the positively charged hydrogenated HPHT ND‐O‐H. [ 46 ] The latter elucidates the observed difficulties in obtaining closed films.…”

Section: Resultsmentioning

confidence: 99%

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Nanodiamonds as Charge Extraction Layer in Organic Solar Cells: The Impact of the Nanodiamond Surface Chemistry

et al. 2023

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Diamond nanoparticles so‐called nanodiamonds (NDs) have recently experienced raising scientific interest due to interesting optical and electronic properties, nontoxicity, biocompatibility, and large surface area. Another significant feature of NDs is the versatility of the surface chemistry, where various functional groups can be attached. This provides an excellent platform for adjusting NDs properties and functions for many applications including in photovoltaic devices. Herein, high‐pressure high‐temperature (HPHT) NDs are tested as charge extraction material in organic solar cells using various surface chemistries: as‐received (HPHT ND‐ar), oxidized (HPHT ND‐O), and hydrogenated (HPHT ND‐O‐H) NDs. Despite the high work function values (≈5.3 eV) of HPHT ND‐ar and HPHT ND‐O, which make these materials normally suitable for hole extraction, devices made with them failed. In contrast, the work function decreases upon hydrogenation (≈4.5 eV) of the beforehand oxidized NDs, making them interesting for electron extraction. By employing such HPHT ND‐O‐H for electron extraction layers, PBDB‐T:ITIC‐based devices reach 77%, while PM6:Y6‐based devices reach even 85% of the performance when process on standard ZnO electron transport layers. Improvement of the film‐forming qualities of this new electron extraction material is expected to further improve the performance.

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Section: Resultsmentioning

confidence: 90%

“…[ 42–45 ] The residual oxygen content on the HPHT ND‐O‐H is less than 2 at% which confirms nearly complete hydrogenation. [ 46 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nanodiamonds as Charge Extraction Layer in Organic Solar Cells: The Impact of the Nanodiamond Surface Chemistry

et al. 2023

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Design Rules for the Nano‐Bio Interface of Nanodiamonds: Implications for siRNA Vectorization

Kindermann,

Neburkova,

Neuhoferova

et al. 2024

Adv Funct Materials

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The enormous therapeutic potential of selective ribonucleic acid (RNA) interference has recently been manifested by the approval of several small interfering RNA (siRNA)‐based drugs. However, the efficacy of siRNA delivery is still limited, and an extensive search for alternative and highly effective delivery approaches is ongoing. With this aim, three generations of non‐viral vectors based on modified nanodiamonds (NDs) have been gradually developed in the past decade. They show great promise due to the negligible toxicity of the ND core. Here, a robust methodological approach is presented to enable the evaluation of new vector nanomaterials. Using a new type of third‐generation ND vector coated with a copolymer with tunable charge density, variables such as colloidal stability, surface electrostatic properties, the molecular composition of the copolymer, and the mode of complexation with siRNA are optimized. Using an innovative data processing strategy, the results are related to biological potency, toxicity, and cell proliferation. Finally, the optimized composition of a coating copolymer consisting of a cationic component, 2‐dimethylaminoethyl methacrylate, and an electroneutral biocompatible component, N‐(2‐hydroxypropyl) methacrylamide, is evaluated. The optimized NDs vectors are colloidally and biologically stable siRNA delivery tools with broad potential for RNA interference‐based therapeutics.

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Nanocomposite Hydrogels from Nanodiamonds and a Self‐Assembling Tripeptide

Marin,

Kralj,

Stehlik

et al. 2024

Chemistry A European J

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We report the successful assembly of a tripeptide in the presence of nanodiamonds (NDs) into nanocomposite hydrogels. The presence of NDs does not hinder peptide self‐assembly and gelation, whilst improving the viscoelastic properties of the hydrogels. Gelation kinetics are not affected by NDs, while the elastic moduli of the peptide hydrogels are significantly increased by the NDs. Increased resistance of the gels against applied stress can also be attained depending on the amount of NDs loaded in the nanocomposite. Raman micro‐spectroscopy and TEM confirmed the presence of NDs on the surface, and not in the interior, of peptide nanofibers. Peptide‐ND non‐covalent interactions are also probed by Raman and Fourier‐transformed infrared spectroscopies. Overall, this work enables the embedding of NDs into nanocomposite hydrogels formed through the self‐assembly of a simple tripeptide at physiological pH, and it provides key insights to open the way for their future applications in biomaterials, for instance exploiting their luminescence and near‐infrared responsiveness.

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Nanodiamonds as traps for fibroblast growth factors: Parameters influencing the interaction

Cited by 13 publications

References 66 publications

Nanodiamonds as Charge Extraction Layer in Organic Solar Cells: The Impact of the Nanodiamond Surface Chemistry

Nanodiamonds as Charge Extraction Layer in Organic Solar Cells: The Impact of the Nanodiamond Surface Chemistry

Design Rules for the Nano‐Bio Interface of Nanodiamonds: Implications for siRNA Vectorization

Nanocomposite Hydrogels from Nanodiamonds and a Self‐Assembling Tripeptide

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