Nanodiamonds: Minuscule gems that ferry antineoplastic drugs to resistant tumors

Ali, Moustafa S.; Metwally, Abdelkader A.; Fahmy, Rania Samir; Osman, Rihab

doi:10.1016/j.ijpharm.2018.12.090

Cited by 23 publications

(29 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Simultaneously, drug retention inside cancer cells exposes the nanodiamond-drug complex to the acidic ambiance (low pH) inside the cells that promotes the release of the drug from the carrier. Accumulation and release of the drug inside cancer cells also reduces side effects of drugs on the surrounding tissue [64] . For example, Wang et al [43] employed epirubicin linked to 5 nm nanodiamond cores.…”

Section: Nanodiamonds Against Drug Resistant Cancermentioning

confidence: 99%

Why nanodiamond carriers manage to overcome drug resistance in cancer

Benson¹,

Amini²

2020

CDR

View full text Add to dashboard Cite

Nanodiamonds represent an attractive potential carrier for anticancer drugs. The main advantages of nanodiamond particles with respect to medical applications are their high compatibility with non-cancerous cells, feasible surface decoration with therapeutic and cancer-cell targeting molecules, and their relatively low manufacturing cost. Additionally, nanodiamond carriers significantly increase treatment efficacy of the loaded drug, so anticancer drugs execute more effectively at a lower dose. Subsequently, lower drug dose results in less extensive side effects. The carriers decorated with a targeting molecule accumulate primarily in the tumor tissue, and those nanodiamond particles impair efflux of the drug from cancer cells. Therapeutic approaches considering nanodiamond carriers were already tested in vitro , as well as in vivo. Now, researchers focus particularly on the possible side effects of nanodiamond carriers applied systemically in vivo. The behavior of nanodiamond carriers depends heavily on their surface coatings, so each therapeutic complex must be evaluated separately. Generally, it seems that site-specific application of nanodiamond carriers is a rather safe therapeutic approach, but intravenous application needs further study. The benefits of nanodiamond carriers are remarkable and represent a potent approach to overcome the drug resistance of many cancers.

show abstract

Section: Nanodiamonds Against Drug Resistant Cancermentioning

confidence: 99%

Why nanodiamond carriers manage to overcome drug resistance in cancer

Benson¹,

Amini²

2020

CDR

View full text Add to dashboard Cite

show abstract

“…Due to the high popularity of CNMs in the cancer theragnostic, many articles on the matter can be found, and additional background information can be found in these excellent articles [130,141,144,[147][148][149][150][151][152][153][154][155] . Additionally, information about how CNMs' intrinsic properties can serve in theragnostic approaches [PTT and PDT, optical imaging, and cargo delivery systems (including stimuli-responsive and cancer cell-selective)] and Figure 9.…”

Section: Carbon-based Nanocarriersmentioning

confidence: 99%

Nanocarrier drug resistant tumor interactions: novel approaches to fight drug resistance in cancer

Benko¹

2020

CDR

View full text Add to dashboard Cite

Cancer is one of the biggest healthcare concerns in our century, a disease whose treatment has become even more difficult following reports of drug-resistant tumors. When this happens, chemotherapy treatments fail or decrease in efficiency, leading to catastrophic consequences to the patient. This discovery, along with the fact that drug resistance limits the efficacy of current treatments, has led to a new wave of discovery for new methods of treatment. The use of nanomedicine has been widely studied in current years as a way to effectively fight drug resistance in cancer. Research in the area of cancer nanotechnology over the past decades has led to tremendous advancement in the synthesis of tailored nanoparticles with targeting ligands that can successfully attach to chemotherapy-resistant cancer by preferentially accumulating within the tumor region through means of active and passive targeting. Consequently, these approaches can reduce the off-target accumulation of their payload and lead to reduced cytotoxicity and better targeting. This review explores some categories of nanocarriers that have been used in the treatment of drug-resistant cancers, including polymeric, viral, lipid-based, metal-based, carbon-based, and magnetic nanocarriers, opening the door for an exciting field of discovery that holds tremendous promise in the treatment of these tumors.

show abstract

“…2 Therefore, biological parameters such as aggregation, metabolism, internalization and toxicity can be controlled, providing better risk-benefit ratio towards therapeutic and bioimaging systems. 3 NDs are classified into different categories depending on their bare size and synthesis process. Detonation nanodiamonds (DNDs) basically exhibit monodisperse size close to 5 nm.…”

Section: Introductionmentioning

confidence: 99%

“…The former gathers milling, sonic disintegration, and annealing techniques, while the latter refers to surface modification by oxygenated functions or small molecules to bring stability to the final materials. 3 DNDs are commonly chosen in anticancer drug delivery systems owing to their low cost, chemical inertia and ability to overcome multidrug resistance. 11 In addition, their high specific surface area and small monodisperse size allow higher release rates and good therapeutic in vivo efficacy via targeting molecules such as polymers, peptides and liposomes.…”

Section: Introductionmentioning

confidence: 99%

“…1, 5,6 They show good relevancy as topical antineoplastic drug delivery transporters, cancer stem cells eradication enhancers and chemoresistance suppressors. 3 Their alterable surface and biocompatibility render them suitable drug carriers protecting against protein adhesion and immune responses, leading to longer circulation time in the body and better selectivity for the tumor sites. 1 NDs have been adapted for use with several drugs, demonstrating positive input and lower side effects.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation