2016
DOI: 10.1021/acs.jpcb.6b07631
|View full text |Cite
|
Sign up to set email alerts
|

Nanodomains in Biomembranes with Recycling

Abstract: Cell membranes are out of thermodynamic equilibrium notably because of membrane recycling, i.e. active exchange of material with the cytosol. We propose an analytically tractable model of biomembrane predicting the effects of recycling on the size of protein nanodomains. It includes a short-range attraction between proteins and a weaker long-range repulsion which ensures the existence of socalled cluster phases at equilibrium, where monomeric proteins coexist with finite-size domains. Our main finding is that … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
20
0

Year Published

2018
2018
2020
2020

Publication Types

Select...
3
1

Relationship

2
2

Authors

Journals

citations
Cited by 4 publications
(20 citation statements)
references
References 62 publications
(299 reference statements)
0
20
0
Order By: Relevance
“…The fact that clusters of any size can coagulate or not depend on whether they feel mutual repulsion or not. Mutual repulsion can be attributed to membrane spontaneous curvature inside clusters [199]. The fact that clusters can split into smaller multimers depends on the line tension λ.…”
Section: Results and Prospectsmentioning
confidence: 99%
See 3 more Smart Citations
“…The fact that clusters of any size can coagulate or not depend on whether they feel mutual repulsion or not. Mutual repulsion can be attributed to membrane spontaneous curvature inside clusters [199]. The fact that clusters can split into smaller multimers depends on the line tension λ.…”
Section: Results and Prospectsmentioning
confidence: 99%
“…; can then be used to build up c n recursively. For MDRR recycling given by [199], with permission from the American Chemical Society, Copyright 2016. In both examples, monomers are injected into the membrane from the cytosol at a rate jon, either by exocytosis in (a) or by a monomer flux from the cytosol in (b).…”
Section: Active and Out-of-equilibrium Processesmentioning
confidence: 99%
See 2 more Smart Citations
“…By means of RT-qPCR experiments, we exclude the possibility that the low mRNA level of KDELRs is responsible for the missing receptor clustering phenotype seen in macrophages. The recycling and cluster formation at cell membranes has more generally attracted attention as a nonequilibrium stochastic process [22,23]. Here we consider a stochastic KDELR endo/ exocytosis model and perform Monte Carlo simulations to better understand how the differences in cluster formation in various cell types may originate from the differences in their endocytosis and/or exocytosis rates.…”
Section: Introductionmentioning
confidence: 99%