Nanodrug constructed using dietary antioxidants for immunotherapy of metastatic tumors

Abstract

Immunogenic cell death (ICD) induced by reactive oxygen species (ROS) represents a particular form of tumor cell death for approaching the problem of low immunogenicity of tumors in immunotherapy, while...

Celecoxib Augments Paclitaxel-Induced Immunogenic Cell Death in Triple-Negative Breast Cancer

“…Three days after the final treatment, the primary tumors were resected. Subsequently, mice were reinoculated with 4T1 cells into the different sides of the mammary gland 21 days after the primary tumor resection and monitored for tumor incidence over a 2-week follow-up period (Figure A), referencing previously published works. − In the PBS group, tumors began to emerge approximately 1 week after the rechallenge and exhibited a 100% tumor incidence (Figure B). However, the PTX/CXB@Lip-cRGD group displayed a significantly reduced tumor incidence rate of 50%, which was substantially lower than 90% observed in the PTX@Lip-cRGD group.…”

Optimization and characterization of miRNA-129-5p-encapsulated poly (lactic-co-glycolic acid) nanoparticles to reprogram activated microglia

“…[25][26][27][28] As a well-known maker of inammatory mediators and cancer therapy, HMGB1 is a direct target of miR-129. [29][30][31] Moreover, HMGB1 is passively released by necrotic and/or stressed cells as well as by immune cells including activated microglia. [26][27][28] Poly (lactic-co-glycolic acid) (PLGA)-based NPs-mediated delivery of miRNA indicated better efficacy on safe miRNA delivery.…”

“…25–28 As a well-known maker of inflammatory mediators and cancer therapy, HMGB1 is a direct target of miR-129. 29–31 Moreover, HMGB1 is passively released by necrotic and/or stressed cells as well as by immune cells including activated microglia. 26–28…”