Nanoemulsification of Rice Bran Wax Policosanol Enhances Its Cardio-protective Effects via Modulation of Hepatic Peroxisome Proliferator-activated Receptor gamma in Hyperlipidemic Rats

Abstract

has lipid-lowering effects 12 19 . Other reports have, however, demonstrated no lipid-lowering effect for policosanol 20 23 . Direct comparisons of these divergent findings have been limited by differences in regional dietary patterns and by the unknown variability of the composition of the policosanol products that were tested 24 . Being lipophilic, policosanol was reported to have bioavailability between 5 to 12 25 . In this regard, we have developed and characterized the policosanol nanoemulsion from rice bran wax, which we found to be very stable 26 . In the present study, we focused on the effects of rice bran wax policosanol POL and its nanoemulsion NPOL on plasma homocysteine, heart and liver histology, and regulation of hepatic PPARG mRNA in hyperlipidemic Sprague Dawley rats.

Consumption of Policosanol (Raydel®) Improves Hepatic, Renal, and Reproductive Functions in Zebrafish: In Vivo Comparison Study among Cuban, Chinese, and American Policosanol

“…Many policosanol products, approximately 25 brands with a 5–40 mg dosage per day, have been developed worldwide as functional foods that commonly claim to lower the blood cholesterol (total cholesterol, TC) level and raise the high-density lipoproteins-cholesterol (HDL-C) level. Since the first policosanol was purified from sugarcane in 1993 [ 12 ], various policosanol products have been isolated from different natural sources and mixed in the global market with some confusion of their origin, such as rice bran [ 13 ] and insects [ 14 ]. Furthermore, the different sources and brands of policosanol exhibited different ingredient compositions of long-chain aliphatic alcohols, such as octacosanol content.…”