Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery

Ali, Asad; Ansari, Valeed Ahmad; Ahmad, Usama; Akhtar, Jamal; Jahan, Afroz

doi:10.1055/s-0043-115124

Cited by 60 publications

(30 citation statements)

References 112 publications

(123 reference statements)

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“…Nanoemulsions are comparatively a new class of biphasic systems that have gained impetus as promising carrier for precise, safe and effective delivery of actives to the skin [26,27]. Radii of nanoemulsion ranges from 10-100 nm which gives them typical blue shining hue and are in a metastable state therefore more stable against flocculation and coalescence, prevented by Brownian motion [28,29]. Advantages of nanoemulsion over microemulsion includes requirement of low surfactant concentration (about 20-25 % for microemulsion whereas 5-10 % is sufficient for nanoemulsion).…”

Section: Nanoemulsions and Microemulsionsmentioning

confidence: 99%

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Ahmad

Khan

et al. 2018

Drug Res (Stuttg)

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The science of formulation involving cosmetic ingredients has always been a challenge since the release of active components greatly depends upon the carrier system involved and the selectivity of skin barrier. The principle obstacle of the skin resides in the epidermis and it's hard for many active components to cross it. The formulation related factors like size of particles, viscosity and lipophilicity of the components also play an important role in permeation of the dermal composition. Though widely used; conventional creams and gels still struggle in terms of success. This work focuses on nano based formulation strategies for successful delivery of cosmetic agents. Novel strategies like nanoemulsion, nanogels, liposomes, aquasomes, niosomes, dendrimers and fullerenes have paved way for successful delivery of dermal formulations to desire depths in the skin.

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Section: Nanoemulsions and Microemulsionsmentioning

confidence: 99%

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Ahmad

Khan

et al. 2018

Drug Res (Stuttg)

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“…Methods used for the Preparation of Nanoemulsion: Preparation of Nanoemulsion requires a huge amount of energy or surfactants sometimes both because it is a non-equilibrated system and hence for the formulation of Nanoemulsion either high energy or low energy system can be utilized Even though high energy level is widely used low emulsification method gives attraction 6 . Energy consumed by the preparation of Nanoemulsion is higher than the energy used by the macro emulsion.…”

Section: Ijpsr (2020) Volume 11 Issue 4 (Review Article)mentioning

confidence: 99%

Untitled

2020

IJPSR

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Nanoemulsion system is a promising vehicle due to the powerful ability to deliver the drug through the skin. Researchers have been conducted to prove its potential for the delivery of the drugs used in many skin disorders. Skin is the largest organ and acts as the first line of defense of our body. After a certain period of time, our skin loses tone and elasticity which is called aging. It is the result of programmed senescence and prolonged environmental injury to the skin. The aim of this review article is to provide information regarding the control of skin aging by the nanoemulsion drug delivery system. Novel carrier systems have a lot of advantages when compared to conventional formulations. There are various approaches to preventing skin aging. The most widely used age combating substances in cosmeceuticals are kinetin, Retinoids, sun filters, herbal ingredients (such as resveratrol, turmeric, and green tea), and antioxidants (such as alpha-tocopherol, ascorbic acid, coenzyme Q10 and lipoic acid). In recent years, these molecules have been formulated as nanosized carriers such as vesicular systems, Therefore, nanocarrier such as liposomes, noisome, microemulsions and nanoparticles have been widely investigated as delivery systems for antioxidants to improve their beneficial effects in the treatment of skin aging. In this review, an overview of cosmetic, product-oriented solutions for skin aging is given and different approaches to combat aging are summarized. This review discusses the role of oxidative events of tissue degeneration and aging in general, and for the skin in particular. The mechanisms involved in intrinsic and extrinsic (photo-) aging are described. To prevent or treat skin aging, topical supplementation with antioxidants is regarded as one of the most promising strategies. Overall review says that antioxidants are most commonly used in anti-aging cosmetic products will be reviewed along with the nanocarrier designed to improve their safety and effectiveness. INTRODUCTION: Nanoemulsion is a type of emulsion which is very fine and metastable in nature, the size of the droplets is smaller than the 100 nanometres. Based on the process used for the preparation of nanoemulsion their structure is identified.

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“…This, in turn, causes a lower dependence of dispersion stability on variations of temperature and pH, among other factors, compared to the thermodynamically stable microemulsions. As consequences, two of the main advantages of nanoemulsions with respect to conventional emulsions are (i) improved resilience toward environmental changes and (ii) robust stability, with shelf‐lives ranging from months to years (Ali, Ansari, Ahmad, Akhtar, & Jahan, ).…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsions: Synthesis, Characterization, and Application in Bio‐Based Active Food Packaging

Espitia

Fuenmayor²,

Otoni

2018

Comp Rev Food Sci Food Safe

158

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The increasing demands for foods with fresh‐like characteristics, lower synthetic additive and preservative contents, and low environmental footprint, but still safe to consume, have guided researchers and industries toward the development of milder processing technologies and more eco‐friendly packaging solutions. As sustainability acquires an increasingly critical relevance in food packaging, bio‐based and/or biodegradable materials stand out as suitable alternatives to their synthetic counterparts. In this context, the use of nanoemulsions has represented a step forward for improving the performance of sustainable food packaging devices, especially for the successful incorporation of new compounds and functionalities into conventional films and coatings. This class of emulsions, featuring unique optical stability and rheological properties, has been developed to protect, encapsulate, and deliver hydrophobic bioactive and functional compounds, including natural preservatives (such as essential oils from plants), nutraceuticals, vitamins, colors, and flavors. This article presents the surfactants (including naturally occurring proteins and carbohydrates), dispersants, and oil‐soluble functional compounds used for designing food‐grade nanoemulsions intended for packaging applications. The improved kinetic stability, bioavailability, and optical transparency of nanoemulsions over conventional emulsions are discussed considering theoretical concepts and real experiments. Bottom‐up and top‐down approaches of nanoemulsion fabrication are described, including high‐energy (such as high‐pressure homogenizers, microfluidics, ultrasound, and high‐speed devices) and low‐energy methods (for instance, phase inversion and spontaneous emulsification). Finally, incorporation of nanoemulsions in biopolymer matrixes intended for food packaging applications is also addressed, considering current characterization techniques as well as their potential antimicrobial activity against foodborne pathogens.

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Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery

Cited by 60 publications

References 112 publications

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

Strategies in Development and Delivery of Nanotechnology Based Cosmetic Products

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Nanoemulsions: Synthesis, Characterization, and Application in Bio‐Based Active Food Packaging

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