Nanoemulsion carriers of porous γ-alumina modified by polyvinylpyrrolidone and carboxymethyl cellulose for pH-sensitive delivery of 5-fluorouracil

Shamsabadipour, Amin; Pourmadadi, Mehrab; Yazdian, Fatemeh; Rashedi, Hamid; Navaei‐Nigjeh, Mona

doi:10.1016/j.ijbiomac.2023.123621

Cited by 28 publications

(4 citation statements)

References 86 publications

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“…Moreover, ongoing intense scientific research explores combinations like polyvinylpyrrolidone (PVP)/carboxymethyl cellulose (CMC)/γ-alumina with 5-fluorouracil (5-FU) to enhance the effectiveness of the cytostatic drug and limit its destructive impact on the body. Such studies were conducted by Shamsabadipour et al [73].…”

Section: Lipid Nanoemulsionsmentioning

confidence: 99%

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Jamroży,

Kudłacik-Kramarczyk,

Drabczyk

et al. 2024

IJMS

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Studies on bionanocomposite drug carriers are a key area in the field of active substance delivery, introducing innovative approaches to improve drug therapy. Such drug carriers play a crucial role in enhancing the bioavailability of active substances, affecting therapy efficiency and precision. The targeted delivery of drugs to the targeted sites of action and minimization of toxicity to the body is becoming possible through the use of these advanced carriers. Recent research has focused on bionanocomposite structures based on biopolymers, including lipids, polysaccharides, and proteins. This review paper is focused on the description of lipid-containing nanocomposite carriers (including liposomes, lipid emulsions, lipid nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers), polysaccharide-containing nanocomposite carriers (including alginate and cellulose), and protein-containing nanocomposite carriers (e.g., gelatin and albumin). It was demonstrated in many investigations that such carriers show the ability to load therapeutic substances efficiently and precisely control drug release. They also demonstrated desirable biocompatibility, which is a promising sign for their potential application in drug therapy. The development of bionanocomposite drug carriers indicates a novel approach to improving drug delivery processes, which has the potential to contribute to significant advances in the field of pharmacology, improving therapeutic efficacy while minimizing side effects.

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Section: Lipid Nanoemulsionsmentioning

confidence: 99%

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Jamroży,

Kudłacik-Kramarczyk,

Drabczyk

et al. 2024

IJMS

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“…101 Phosphate ions not only are found in the blood and have no health risks and toxic effects but are also essential to skeleton growth and bone repair, facilitating osteogenesis and osteointegration. 50,102 Because of these characteristics, BP is a highly desired 2D material for phototherapy of cancers, 103 bioimaging, 104 biosensors, 105 theranostics, 106 drug delivery, [107][108][109] scaffolds for implantation into the body, 110 and other bioengineering and biomedical applications. Even so, the use of this biodegradable material for tissue engineering is now in its early stages, with relatively, limited investigations provided.…”

Section: Black Phosphorus (Bp)mentioning

confidence: 99%

Two‐dimensional materials for bone‐tissue engineering

et al. 2023

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There are diverse diseases such as some infections, trauma, and tumor resections during cancer surgery that can cause bone damage or skeletal defects in persons. Most of the time, these defects cannot heal spontaneously due to several medical conditions that patients encounter, like diabetes, hormone-related problems, and autoimmune disorders. This issue is even worse for older people and some special treatments should be provided for them. Bone-tissue engineering has emerged to tackle these challenges. By investigating bone repair strategies, studying bone structures and biomechanics, and employing appropriate growth factors, suitable scaffolds, and biomaterial-centered regenerative approaches can be employed to treat bone defects more effectively. This study reviews some recent bone-tissue-engineering strategies relying on two-dimensional (2D) materials, including graphene and its derivatives, black phosphorus, and MXenes that are exhibiting a great potential in regenerative medicine.

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“…Due to the serious adverse side effects of the chemotherapeutic agents, advanced methods for curing cancer, such as nanogel used to carry and release 5-fluorouracil to minimize side effects and optimized their pharmaceutic effect. Moreover, encapsulation or conjugation of 5-FU within nanoparticle drug delivery systems leads to high-performance issues due to distribution, bio-homogeneity, and biodegradation of the carrier moieties [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antitumor activity of 5-fluorouracil polymeric nanogel synthesized by gamma radiation on a rat model of colon carcinoma: a proposed mechanism

et al. 2023

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The use of 5-fluorouracil (5-FU) is associated with multifaceted challenges and poor pharmacokinetics. Accordingly, our study was designed to prepare 5-FU nanogel as a new form of the colon cancer chemotherapeutic drug 5-FU using polyacrylic acid and gelatin hybrid nanogel as efficient drug carriers. Alongside the in vivo chemotherapeutic evaluation, the anti-proliferative and anti-apoptotic efficacy were carried out for 5-FU nanogel against 1,2-dimethylhydrazine (DMH, 20 mg/kg) and γ-radiation (4 Gy)-prompted colon dysplasia in rats compared to 5-FU. The morphology and size of 5-FU nanogel were characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS) in addition to cytotoxicity assay. The expression of phosphoinositide-3-kinase (PI3K)/Akt, mammalian target of rapamycin (mTOR); Toll-like receptor2 (TLR2)/nuclear factor kappa B), adenosine monophosphate (AMP)-activated protein kinase (AMPK) and its downstream autophagy-related genes in addition to apoptotic markers were measured in colon tissues. Results: 5-FU nanogel reduced the levels of the TLR2/ NF-κβ as well as the expression of PI3K/AKT/mTOR. Moreover, it promoted autophagy through the activation of the AMPK and its downstream targets which consequently augmented the intrinsic and extrinsic apoptotic pathways. Conclusion: Collectively, these data might strengthen the therapeutic potential of 5-FU nanogel which can be used as an antitumor product for colon cancer.

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Nanoemulsion carriers of porous γ-alumina modified by polyvinylpyrrolidone and carboxymethyl cellulose for pH-sensitive delivery of 5-fluorouracil

Cited by 28 publications

References 86 publications

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Advanced Drug Carriers: A Review of Selected Protein, Polysaccharide, and Lipid Drug Delivery Platforms

Two‐dimensional materials for bone‐tissue engineering

Antitumor activity of 5-fluorouracil polymeric nanogel synthesized by gamma radiation on a rat model of colon carcinoma: a proposed mechanism

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